Abstract:The first conceptualization that the immune system (IS) could possess a communication mechanism analogous to the chemically-mediated neuronal synapses was developed by Norcross in 1984 [1]. In 1988, the observation that the T lymphocytes are capable of releasing cytokines in a specific direction -or, from a specific membrane region -allowed he revisiting of the notion of a synapse. The synapse was subsequently defined based on the intimate contact between two cellular surfaces, promoted by the binding of prote… Show more
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