Immunological Susceptibility of Metropolis Population to Measles in its Elimination Stage

Nozdracheva, Anna; Семененко, Т А; Асатрян, М. Н.; Шмыр, И. С.; Ershov, Ivan F.; Соловьев, Д. В.; Глиненко, В. М.; Кузин, С. Н.

doi:10.31631/2073-3046-2019-18-2-18-26

Cited by 13 publications

(11 citation statements)

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“…В опубликованной нами ранее работе [16] был подробно изучен ключевой показатель качества проводимой в стране вакцинопрофилактики -охват профилактическими прививками населения (в плановом порядке и по эпидемическим показаниям) по результатам анализа созданной электронной базы данных о расследованиях случаев кори в очагах.…”

Section: A R T I C L E I N P R E S Sunclassified

“…Сопоставление полученных данных [16] об охвате профилактическими прививками населения Москвы, а также результатов серологических исследований популяционного иммунитета указанного контингента позволит оценить долю восприимчивых к кори лиц и понять причины осложнения эпидемической ситуации по данной инфекции в настоящее время.…”

Section: A R T I C L E I N P R E S Sunclassified

“…При проведении серологических исследований среди населения Москвы за период с 2013 по 2017 г. все обследованные лица были разделены на возрастные группы (рис. 1) в соответствии с результатами расчета охвата вакцинацией населения [16].…”

Section: анализ в подгруппахunclassified

“…(под управлением системы управления баз данных MySQL и с использованием Microsoft Excel). Подробное описание этапов предварительной обработки собранных материалов, получение информационного массива с последующим преобразованием его в электронную базу данных и результаты расчета охвата населения профилактическими прививками и охвата экстренной вакцинацией лиц в очагах изложены нами ранее [16].…”

Section: A R T I C L E I N P R E S Sunclassified

“…Группа от 0 до 2 лет. По данным расследования случаев кори, охват профилактическими прививками среди детей раннего возраста составил 55,9% [16]. В указанную возрастную группу входят дети до 1 года, которые не подлежат вакцинации в соответствии с календарем прививок (в т.ч.…”

Section: основные результаты исследованияunclassified

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Multivariate analysis of the megacity population immunity to measles

et al. 2019

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Background: The significant reduction of measles and rubella morbidity and child mortality, which allowed WHO to set a target for their elimination by 2010, is one of the finest examples of the vaccine prevention effectiveness in the fight against infectious diseases. However, in the period from 2010 to 2019 there was a controversial situation with respect to measles, characterized by the presence of high vaccination coverage of the population on the one hand, and an increase in the incidence on the other. Obviously, the key point in resolving these contradictions is to analyze the susceptibility of the population. Aim: Of the study was to assess the susceptibility of Moscow population to measles in the context of factors affecting its formationю. Methods: Epidemiological, serological, statistical methods and GIS technologies were used in the work. The serological study (using the solid-phase ELISA method) included 2410 blood serum samples collected between 2013 and 2017 from healthy residents of Moscow aged from birth to 60 years. On the basis of documents on sanitary and epidemic investigation of measles cases in Moscow (20132015) a relational database under the management of MySQL Database Management System was formed, based on the analysis of which the coverage of the population with preventive vaccinations was estimated. Results: Оn average, the proportion of seronegative persons to measles in 20162017, compared with 20132014 (20.5%) increased and amounted to 29.0% mainly due to the group over 36 years. The most vulnerable were children aged 12 years and 36 years, where the share of the immune persons amounted to 51,5% and 37.9%, respectively, at low coverage in a planned manner (55,9% [95% CI, 52.2 per cent; of 59.5%] and 75,3% [95% CI, 73.3 per cent; for 77.2%]). The proportion of vaccinated persons who lost post-vaccination immunity under the influence of factors preventing its formation (from 3.6% to 21.6% in the group of 714 years; from 11.8% to 26.4% in the group of 1517 years) was calculated. The possibility of visualizing the spread of measles on electronic maps for the territorial and temporal analysis of the epidemic situation is shown. Conclusions: It is reasonable to assume that over the time, the proportion of people who have suffered measles will decrease, and the proportion of people not covered by vaccination or lost post-vaccination immunity - increase, that can lead to a decrease in herd immunity and requires correction of vaccination work. The proposed information and analytical system for monitoring the epidemiological situation allows to work quickly with heterogeneous resources and choose on electronic maps the area of interest from the global level (country) to the local (house), which is necessary for the adoption of scientifically based preventive and epidemiological measures.

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Section: анализ в подгруппахunclassified

Section: A R T I C L E I N P R E S Sunclassified

Section: основные результаты исследованияunclassified

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Multivariate analysis of the megacity population immunity to measles

et al. 2019

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Influence of long-term storage of blood serum samples in a biobank for population-based seroepidemiologic studies

Nozdracheva¹,

Semenenko²

2022

Cardiovasc Ther Prev

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Aim. To assess the safety of IgG antibodies during long-term storage of blood serum samples using measles- and rubella-specific antibodies as an example.Material and methods. The study used serum samples from the collection of the Department of Epidemiology of the Gamaleya National Research Center for Epidemiology and Microbiologya, which were tested for measles- or rubella-specific IgG antibodies immediately upon admission to the laboratory, were frozen and stored at -70оC (n=180). The samples were reexamined after 20 months (n=90) and 6 years (n=90).Results. Reexamination after 20-month storage showed a decrease in the mean level of measles- and rubella-specific antibodies by 13,1% (from 0,36 (0,08-1,21) to 0,31 (0,02-1,2) IU/ml) and by 11,8% (from 151,4 (45-235) to 133,5 (72-198) IU/ml), respectively (p<0,05 for all). At the same time, the number of seronegative samples did not change. After a 6-year storage period, the mean level of measles-specific antibodies decreased by 33,8% (p<0,05) from 0,72 (0,4-1,79) to 0,34 (0,18-1,14) IU/ml and only two samples became seronegative. It was shown that the higher the IgG level in native samples, the more pronounced its decrease was during the second examination.Conclusion. Storage of serum samples in a biobank for 20 months at -70оC ensures the safety of measles- and rubella-specific IgG antibodies, and is the basis for the reliability of future studies.

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Possibilities of a biobank for serological monitoring of infectious morbidity

Svitich,

Zverev,

Solomay

et al. 2023

Cardiovasc Ther Prev

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Currently, monitoring infectious morbidity, control and forecasting the epidemic process is a topical health problem.Aim. To analyze the capabilities of the biobank for serological monitoring of infectious diseases using the Epstein- Barr virus (EBV), which is associated with infectious mononucleosis, as well as somatic pathology, including cancer.Material and methods. Using the quantitative enzyme- linked immunosorbent assay for specific antibodies to various EBV proteins, we studied blood serum samples from healthy individuals (2010, 2016, 2019, 2020, 2021 and 2022) from the collection of the N. F. Gamaleya National Center of Epidemiology and Microbiology.Results. For the first time, the intensity of EBV epidemic process among apparently healthy adult residents of the capital was assessed using samples of biological material and a biobank information database. At the time of examination, 0,8% of individuals were not infected with EBV, and 9,4% suffered reactivation of a chronic infection. There were no significant changes in detection rate of markers over the years.Conclusion. Certified collections of blood sera can be effectively used to study population immunity, the prevalence of individual infections, population protection nationwide, etc.

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Immunological Susceptibility of Metropolis Population to Measles in its Elimination Stage

Cited by 13 publications

References 6 publications

Multivariate analysis of the megacity population immunity to measles

Multivariate analysis of the megacity population immunity to measles

Influence of long-term storage of blood serum samples in a biobank for population-based seroepidemiologic studies

Possibilities of a biobank for serological monitoring of infectious morbidity

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