Immunological Study of Pustulosis Palmaris Et Plantaris: Blastoid Transformation of Tonsil and Peripheral Blood Lymphocytes by Stimulation with Human Skin Extract

Tanaka, Norio; Ichino, Yukinori; Ikawa, Tsutomu; Ishikawa, Takeru

doi:10.3109/00016488309121160

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Among such autoantigens, keratin is reportedly a probable candidate. The keratin‐specific antibody titers in serum were significantly higher in PPP patients . Moreover, the degree of improvement in skin lesions was closely related to the changes in antikeratin IgM antibody titers after tonsillectomy .…”

Section: Pathogenic Role Of Tonsils In Pppmentioning

confidence: 91%

“…The keratin-specific antibody titers in serum were significantly higher in PPP patients. [72][73][74] Moreover, the degree of improvement in skin lesions was closely related to the changes in antikeratin IgM antibody titers after tonsillectomy. 73 Hayashi and Tabata 72 demonstrated that high molecular weight keratin is distributed over both palmoplantar skin and the tonsil epithelium of PPP patients, and the level of serum antibody toward keratin is higher in PPP patients.…”

Section: Recruitment Of Tonsillar T Cells To the Skinmentioning

confidence: 95%

“…found that human leukocyte antigen‐DR antigen levels and T‐cell invasion were enhanced in the tonsil epithelium of PPP patients. Tanaka et al . demonstrated that tonsillar T cells from PPP patients exhibited high blast transformation levels because of stimulation with human skin extract.…”

Section: Pathogenic Role Of Tonsils In Pppmentioning

confidence: 99%

“…In addition, Kimura et al 88 found that human leukocyte antigen-DR antigen levels and T-cell invasion were enhanced in the tonsil epithelium of PPP patients. Tanaka et al 74 demonstrated that tonsillar T cells from PPP patients exhibited high blast transformation levels because of stimulation with human skin extract. Koshiba et al 89 found that lymphoid follicles in PPP tonsils were often surrounded by epithelial cells contiguous to the crypts, in which tonsillar epithelial crypt cells secreted a high amount of IL-6, an inducer of Th17.…”

Section: Recruitment Of Tonsillar T Cells To the Skinmentioning

confidence: 99%

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Pathogenic role of palatine tonsils in palmoplantar pustulosis: A review

Harabuchi

Takahara

2019

The Journal of Dermatology

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Palmoplantar pustulosis (PPP) is characterized by symmetrical, erythematous, scaly plaques, with numerous, sterile, non‐bacterial, pinpoint pustules, which are restricted to the palms and soles. Because several reports have described the efficacy of tonsillectomy for improvement in PPP skin lesions, we consider that PPP is tonsil‐induced autoimmune/inflammatory syndrome (TIAS) while other factors are also involved in the pathogenesis of PPP. Here, the association between PPP pathogenesis and TIAS was examined, with a focus on results of previous studies. PPP patients show a hyperimmune response to indigenous bacteria such as α‐streptococci, due to impaired immunological tolerance towards such organisms. Such a novel immune response leads to T‐cell activation through the abnormal expression of secondary stimulation molecules, including cytotoxic T‐lymphocyte‐associated antigen 4, inducible T‐cell co‐stimulator and Smad7, in the tonsils of PPP patients. Activated tonsillar T cells express cutaneous lymphocyte antigen (CLA), CCR6 and β1‐integrin, enter the blood circulation and are recruited to PPP skin lesions. Within lesions, T cells roll onto endothelial cells through the interaction between CLA and E‐selectin, migrate into the extravascular area through β1‐integrin–vascular cell adhesion molecule 1 binding, and assemble in the skin through CCL20–CCR6 binding. Hyperimmune responses to autoantigens such as keratin and heat shock proteins could also be involved in PPP pathogenesis, through the stimulation of the T‐helper 17 reaction.

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Section: Pathogenic Role Of Tonsils In Pppmentioning

confidence: 91%

Section: Recruitment Of Tonsillar T Cells To the Skinmentioning

confidence: 95%

Section: Pathogenic Role Of Tonsils In Pppmentioning

confidence: 99%

Section: Recruitment Of Tonsillar T Cells To the Skinmentioning

confidence: 99%

See 2 more Smart Citations

Pathogenic role of palatine tonsils in palmoplantar pustulosis: A review

Harabuchi

Takahara

2019

The Journal of Dermatology

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“…The concept that altered antigens in the squamous epithelium of palatine tonsils may serve as a stimulatory source for autoantibodies in diseases of the palms and soles has been maintained for over 75 years (Andrew and Machacek, 1935;Tanaka et al, 1983). Furthermore, some renal disorders such as IgA nephropathy and glomerulonephritis (see Chapter 105) have been associated with inflammatory diseases of the upper respiratory tract (Miura et al, 1984).…”

Section: Tonsils As a Putative Source Of Autoantibodiesmentioning

confidence: 96%