Immunological's host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor

Simonetti, Ana Catarina; Melo, José Humberto de Lima; Souza, Paulo Roberto Eleutério de; Bruneska, Danyelly; Filho, José Luiz de Lima

doi:10.1016/j.micinf.2009.01.004

Cited by 46 publications

(34 citation statements)

References 43 publications

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“…In addition, it has been reported that C. trachomatis-induced chronic inflammation produces a local immune perturbation that decreases the number of antigen-presenting cells involved in the clearance of HPV (Malinverni, 1996;Silva et al, 2014;Simonetti et al, 2009;Soper, 2010;Vidhani et al, 2005). Nevertheless, although several epidemiological studies have found a positive association between C. trachomatis-and HPV-related cervical lesions and cervical cancer, the specific relationship between infections by these micro-organisms and cervical neoplasia has not as yet been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Seraceni

Campisciano

Contini

et al. 2016

Journal of Medical Microbiology

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Human papillomavirus (HPV) and Chlamydia trachomatis are pathogens with oncogenic potential associated with persistent infections. Epidemiological data on C. trachomatis infection status, C. trachomatis/HPV co-infection and the relationship between HPV genotypes in Italian women are only preliminary. The aim of the present study was to characterize the relationship between HPV genotypes and C. trachomatis in an extending cohort of asymptomatic immunocompetent women from an area of north-east Italy. A retrospective study was conducted using Luminex technology on cervical swabs from asymptomatic immunocompetent women, comprising 921 attending the prevention centre for the Cervical Cancer Program and 6214 who had been referred to the Sexually Transmitted Infections Center, with clinical indications of HPV and C. trachomatis infections. A quantitative real-time PCR was performed to assess chronic C. trachomatis infection by heat-shock protein 60 (Hsp60) gene expression. The overall prevalence of the investigated pathogens was 39 % (359/921) for HPV and 4 % (251/6214) for C. trachomatis. The Hsp60 gene was detected in 57 % of the women infected with C. trachomatis. HPV co-infection was present in 58 % of C. trachomatis-infected women. A high prevalence of co-infection was found in women with chronic C. trachomatis infection (68 %, P50.0002), especially in women j25 years (72 %) where HPV multiple infections were found in 78 % (P50.022). HPV genotype distribution showed that uncommon low-risk genotypes were associated with C. trachomatis. These results indicate a high frequency of co-detection of multiple HPV genotypes in chronically infected young women and suggest that the expression of the C. trachomatis Hsp60 gene may favour HPV infection.

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Section: Introductionmentioning

confidence: 99%

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Seraceni

Campisciano

Contini

et al. 2016

Journal of Medical Microbiology

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“…Correct diagnosis of infection with Chlamydia trachomatis is essential as false negative results may have significant impact on societal health [9]. Chlamydial infections has been associated with a higher risk of acquiring HIV-1 infection [4,10] as well as cervical cancer [11] and adverse outcomes with pregnancy [12,13]. For these reasons, early correct diagnosis of infection with Chlamydia trachomatis is essential to prevent long-term sequelae associated with prolonged infection.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Chlamydia trachomatis Infection

Visser¹,

Hoosen²

2012

Chlamydia

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“…[4][5][6] However, the asymptomatic nature of CT infection, its long-term persistence in the absence of treatment, and its capability of inducing metaplasia and chronic inflammation are well-defined characteristics to strongly consider this bacteria as a potential cofactor for high-risk persistent HPV infection (the main proven cause of CC). [7][8][9] HPV genital infection is highly frequent worldwide and its prevalence in the general population ranges from 2-44% depending on the region of the world. 10 However, it is known that most HPV infections are transient and only a small proportion of women with high-risk persistent HPV infection will develop CC.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 CT is one of these cofactors. 4,8,9 The annual mortality rate for CC in Argentina is 7.8/100,000 women, but this rate is three times higher in the northeastern region of the country, 16 where a wide spectrum of Indian and isolated white communities live in unfavorable socioeconomic and health conditions. The aim of this study was to determine the prevalence of CT and HPV infections among vulnerable populations of native Indians belonging to the Pilaga community in northern Argentina.…”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina

Deluca¹,

Basiletti²,

Schelover³

et al. 2011

Braz J Infect Dis

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Objectives: High-risk types of human papillomavirus (HPV) are strongly associated with cervical cancer (CC), and Chlamydia trachomatis (CT), the most frequent sexually transmitted bacterial infection (STBI) worldwide, seems to be a risk factor for HPV infection and for CC. It is also known that both agents are more prevalent in vulnerable communities where lack of adequate primary health care is a cause for concern. The aim of this work was to determine the impact of CT and HPV infections in women belonging to an isolated aboriginal population (Pilaga community) from a poor region in Northern Argentina (province of Formosa). For this purpose, a cross-sectional study was performed in all sexually active Pilaga women, who attended a local community-based gynecological health screening project. The polymerase chain reaction (PCR) method on a cervical brush specimen was used to detect both agents. Results: A total of 227 women (20% of the total female population of the Pilaga community) were studied and the overall prevalence was 26.4% for CT, 46.7% for HPV and 16.3% for concurrent infection. CT infection was higher in HPV DNA positive (34.2%) than in HPV DNA negative women (19%; OR: 2.22/95% CI = 1.16-4.28 / p = 0.009) and the most prevalent HPV types were HPV-16 (19.4%), 6 and 18 (5.3%), 58 (3.5%) and 33 (3.1%). Conclusions:The prevalence of CT and HPV observed in Pilaga women are among the worst registered in Latin America. Also, data collected suggest that chlamydial infection may play an important role in the natural history of HPV infection. On this respect, we propose that the association between these two agents seems to be more related to a mutual potentiation than to the fact that they share a common route of transmission.

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Immunological's host profile for HPV and Chlamydia trachomatis, a cervical cancer cofactor

Cited by 46 publications

References 43 publications

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from north-east Italy

Diagnosis of Chlamydia trachomatis Infection

Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina

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