Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

Wang, Taia T.; Bournazos, Stylianos; Ravetch, Jeffrey V.

doi:10.1016/j.coi.2018.04.026

Cited by 20 publications

(18 citation statements)

References 54 publications

(62 reference statements)

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“…This phenomenon has been referred to as ‘original antigenic sin’ (OAS) 9–11 and is especially relevant in the context of annual infections and vaccinations with drifting and shifting influenza viruses. 12,13 Also in the case of flaviviruses, OAS phenomena can play an important role, 14,15 as a result of sequential exposures to flaviviruses that co-circulate in the same geographical regions, global travel-related exposures, and/or immunization with different flavivirus vaccines, which is the topic of the present work.…”

Section: Introductionmentioning

confidence: 95%

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

et al. 2019

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Flaviviruses have an increasing global impact as arthropod-transmitted human pathogens, exemplified by Zika, dengue, yellow fever (YF), West Nile, Japanese encephalitis, and tick-borne encephalitis (TBE) viruses. Since all flaviviruses are antigenically related, they are prone to phenomena of immunological memory (‘original antigenic sin’), which can modulate immune responses in the course of sequential infections and/or vaccinations. In our study, we analyzed the influence of pre-existing YF vaccine-derived immunity on the antibody response to TBE vaccination. By comparing samples from YF pre-vaccinated and flavivirus–naive individuals, we show that YF immunity not only caused a significant impairment of the neutralizing antibody response to TBE vaccination but also a reduction of the specific TBE virus neutralizing activities (NT/ELISA-titer ratios). Our results point to a possible negative effect of pre-existing cross-reactive immunity on the outcome of flavivirus vaccination that may also pertain to other combinations of sequential flavivirus infections and/or vaccinations.

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Section: Introductionmentioning

confidence: 95%

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

et al. 2019

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“…Type II FcγRs engage ICs containing sialylated IgG Fc domains, which can result in anti‐inflammatory activity [via DC‐SIGN during intravenous immunoglobulin (IVIG) therapy] or high‐affinity antibody production (via B‐cell CD23 engagement) . Increased sialylation correlates with greater antibody affinity following human influenza vaccination . It has been proposed that influenza vaccination results in the production of sialylated anti‐HA IgG antibodies by plasmablasts, which form ICs with vaccine antigen .…”

Section: Fc‐mediated Effector Functions Of Antibodies and Fcrsmentioning

confidence: 99%

“…It has been proposed that influenza vaccination results in the production of sialylated anti‐HA IgG antibodies by plasmablasts, which form ICs with vaccine antigen . The sialylated ICs are delivered to lymph node germinal centers by subcapsular macrophages and noncognate B cells through interactions with CD23 . Sialylated ICs may associate with follicular dendritic cells prolonging contact between B cells and influenza antigen, driving affinity maturation of antibodies in the germinal center (GC) .…”

Section: Fc‐mediated Effector Functions Of Antibodies and Fcrsmentioning

confidence: 99%

The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens

Vanderven

Kent

2020

Immunol Cell Biol

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In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc‐mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza‐specific antibodies with Fc‐mediated functions, such as antibody‐dependent cellular cytotoxicity and antibody‐dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc‐mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc‐mediated effector functions against viral infections with a focus on influenza virus.

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“…Zhang et al [60] demonstrated that Abs enter GCs, bind antigen held on FDCs, and compete with GC B cells in an affinity-dependent way. Through these mechanisms, Abs derived from preexisting MBCs could facilitate affinity maturation of responses to drifted epitopes on the HA head [61]. In the case of MBC-derived anti-stalk Abs, GC B cell selection would be shifted towards targeting the immunodominant HA head [62].…”

Section: Regulation Of the Anti-ha Response By Mbc-derived Antibodiesmentioning

confidence: 99%

Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection

2019

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When influenza A virus infects an immune individual, preexisting memory B cell (MBC) activation and rapid anamnestic antibody production plays a key role in viral clearance. The most effective neutralizing antibodies target the antigenically variable head of the viral hemagglutinin (HA); antibodies against the conserved HA stalk provide broader but less potent protection. In this review, we provide a comprehensive picture of an adult’s HA-specific antibody response to influenza virus infection. The process is followed from preexisting HA-specific MBC activation and rapid production of anti-HA antibodies, through to germinal center seeding and adaptation of the response to novel features of the HA. A major focus of the review is the role of competition between preexisting MBCs in determining the character of the HA-reactive antibody response. HA novelty modifies this competition and can shift the response from the immunodominant head to the stalk. We suggest that antibodies resulting from preexisting MBC activation are important regulators of anti-HA antibody production and play a role in positive selection of germinal center B cells reactive to novel HA epitopes. Our review also considers the role of MBCs in the effects of early-life imprinting on HA head- and stalk-specific antibody responses to influenza infection. An understanding of the processes described in this review will guide development of vaccination strategies that provide broadly effective protection.

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Immunological responses to influenza vaccination: lessons for improving vaccine efficacy

Cited by 20 publications

References 54 publications

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

The protective potential of Fc‐mediated antibody functions against influenza virus and other viral pathogens

Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection

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