Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

Bradt, Victoria; Malafa, Stefan; Braun, Amrei von; Jarmer, Johanna; Tsouchnikas, Georgios; Medits, Iris; Wanke, Kerstin; Karrer, Urs; Stiasny, Karin; Heinz, Franz X.

doi:10.1038/s41541-019-0133-5

Cited by 47 publications

(37 citation statements)

References 51 publications

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“…However, there are also indications that the quality of antibodies can be impeded by prior flavivirus immunity. For example, in one study, individuals pre-vaccinated against YFV were shown to have a lower ratios of neutralizing to ELISA antibody titers (70), emphasizing that the quality of immune responses and not only the magnitude are important in determining the potential of cross-reactive immunity to induce protection versus pathology (Figure 2).…”

Section: Flavivirus Cross-reactive Antibody Responsesmentioning

confidence: 99%

Cross-Reactive Immunity Among Flaviviruses

2020

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Flaviviruses consist of significant human pathogens responsible for hundreds of millions of infections each year. Their antigenic relationships generate immune responses that are cross-reactive to multiple flaviviruses and their widespread and overlapping geographical distributions, coupled with increases in vaccination coverage, increase the likelihood of exposure to multiple flaviviruses. Depending on the antigenic properties of the viruses to which a person is exposed, flavivirus cross-reactivity can be beneficial or could promote immune pathologies. In this review we describe our knowledge of the functional immune outcomes that arise from varied flaviviral immune statuses. The cross-reactive antibody and T cell immune responses that are protective versus pathological are also addressed.

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Section: Flavivirus Cross-reactive Antibody Responsesmentioning

confidence: 99%

Cross-Reactive Immunity Among Flaviviruses

2020

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“…The flavivirus E proteins used in this study (Table 1) were produced with the Drosophila expression system (Invitrogen) as described previously [40,[43][44][45]. The expression vector pT389 (kindly provided by Thomas Krey and Felix Rey, Institute Pasteur, France), encoding the E gene lacking the stem-anchor region (synthesized by GeneArt/Thermo Fisher Scientific, Table 1), an enterokinase cleavage site and a double strep-tag (C-terminal), was transfected into Drosophila S2 cells by CaCl 2.…”

Section: Recombinant Antigensmentioning

confidence: 99%

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans

et al. 2020

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Background Zika virus has recently spread to South-and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g. dengue virus) or flavivirus vaccinations. Since pre-existing cross-reactive immunity can potentially modulate antibody responses to Zika virus infection and may affect the outcome of disease, we analyzed fine-specificity as well as virus-neutralizing and infection-enhancing activities of antibodies induced by a primary Zika virus infection in flavivirus-naïve as well as yellow fever-and/or tick-borne encephalitisvaccinated individuals. Methodology Antibodies in sera from convalescent Zika patients with and without vaccine-induced immunity were assessed by ELISA with respect to Zika virus-specificity and flavivirus cross-reactivity. Functional analyses included virus neutralization and infection-enhancement. The contribution of IgM and cross-reactive antibodies to these properties was determined by depletion experiments.

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“…Broadly cross-reactive antibody responses are also known for other enveloped RNA viruses, which may positively or negatively affect subsequent infection or vaccination. Flaviviruses for example, are antigenically related and broadly flavivirus cross-reactive antibodies from previous yellow fever vaccination has been shown to impair and modulate immune responses to tick-borne encephalitis vaccination [65]. Similarly, immune history has been shown to profoundly affect protective B cell responses to influenza [66].…”

Section: Discussionmentioning

confidence: 99%

Distinct antibody repertoires against endemic human coronaviruses in children and adults

Khan

Rahman

Ali

et al. 2020

Preprint

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19Four endemic human coronaviruses (HCoVs) are commonly associated with acute respiratory 20 infection in humans but immune responses to these "common cold" viruses remain 21 incompletely understood. Moreover, there is evidence emerging from independent studies 22 which suggests that endemic HCoVs can induce broadly cross-reactive T cell responses and 23 may thereby affect clinical outcomes of acute infections with the phylogenetically related 24 epidemic viruses, namely MERS-CoV and SARS-CoV-2. Here we report a comprehensive 25 retrospective analysis of CoV-specific antibody specificities in a large number of samples from 26 children and adults using Phage-Immunoprecipitation Sequencing (PhIP-Seq). We estimate 27 the seroprevalence for endemic HCoVs to range from ~4% to ~27% depending on species and 28 cohort. Most importantly, we identified a large number of novel linear B cell epitopes of HCoV 29 proteins and demonstrate that antibody repertoires against endemic HCoVs are qualitatively 30 different in children in comparison to the general adult population and healthy adult blood 31 bank donors. We show that anti-HCoV IgG specificities more frequently found among children 32 target functionally important and structurally conserved regions of the HCoV spike and 33 nucleocapsid proteins and some antibody specificities are broadly cross-reactive with 34 peptides of epidemic human and non-human coronavirus isolates. Our findings shed light on 35 the humoral immune responses to natural infection with endemic HCoVs and may have 36 important implications for understanding of the highly variable clinical outcomes of human 37 coronavirus infections, for the development of prophylactic or therapeutic monoclonal 38 antibodies and vaccine design. 39 parainfluenza viruses (HPIVs), albeit with differences in seasonality and prevalence of the 48 viruses depending on the species [5-7]. In addition to the four endemic HCoV, three epidemic 49 coronaviruses (CoVs) have emerged in humans over the last two decades, including Severe 50 Acute Respiratory Syndrome-associated CoV (SARS-CoV) [8], Middle East Respiratory 51

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Pre-existing yellow fever immunity impairs and modulates the antibody response to tick-borne encephalitis vaccination

Cited by 47 publications

References 51 publications

Cross-Reactive Immunity Among Flaviviruses

Cross-Reactive Immunity Among Flaviviruses

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans

Distinct antibody repertoires against endemic human coronaviruses in children and adults

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