Immunological Response Induced by Alternated Cooling and Heating of Breast Tumor

Abstract

A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.

Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report

“…In prior reports, combined cryo-heat therapy resulted in stimulation of a cytotoxic T-lymphocyte response, as well as attraction of immunocytes into tumour debris. 3 In our case, freezing the tumour was a problem due to its size. At first, we simply applied a cotton swab soaked with liquid nitrogen but could freeze only the tumour surface.…”

Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements

“…Thermal therapy and the digestion of collagenase to collagen fibers are two good tools. The luciferin-loaded nanostructures in this study have great potential for studying the difference of nanostructures and tumor stroma after operation, thermal therapy, or treatment with collagenase [26,27].…”