Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report

Hachisuka, Junichi; Doi, Kazuko; Furue, Masutaka

doi:10.1016/j.ijscr.2011.10.016

Cited by 12 publications

(3 citation statements)

References 5 publications

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“…Finally, hyperthermia was also used in combination with cryotherapy. The efficacy of this combined treatment was shown for the treatment of a large metastatic breast tumor of 12 cm in diameter, which could not successfully be treated by cryosurgery alone but disappeared completely when cryosurgery was combined with hyperthermia, 34 .…”

Section: Bc Treatments Involving Hyperthermiamentioning

confidence: 99%

Perspectives of Breast Cancer Thermotherapies

Alphandéry¹

2014

J. Cancer

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In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carried out alone to eradicate small breast tumors. A recently developed thermotherapy, called magnetic hyperthermia, which involves localized heating of nanoparticles under the application of an alternating magnetic field, is also presented. The advantages and drawbacks of these different thermotherapies are highlighted.

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Section: Bc Treatments Involving Hyperthermiamentioning

confidence: 99%

Perspectives of Breast Cancer Thermotherapies

Alphandéry¹

2014

J. Cancer

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“…Topical interventions are attractive for its easy self-administration without any major systemic interference. Combination cryosurgery with hyperthermia, radiation therapy and its modalities, topically applied miltefosine or imiquimod and radiobiological approaches like re-irradiation in conjunction with liposomal doxorubicin showed only modest activities in a relatively heavily pretreated patient population, but they are very effective in order to palliate the symptoms (Fritz 2000;Smorenburg, 2000;Kouloulias 2003;Adams, 2012;Hachisuka, 2012). However, all these treatments are not long-term solutions and more efficient medications are necessary.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Therapy for Breast Cancer Patients with Skin Metastases Refractory to Conventional Treatments

Varol

Yıldız²,

Alacacıoğlu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Skin metastases of breast cancer are usually late events in the course of tumor progression and signify a poor prognosis. They may remain as a therapeutic challenge especially after failure of standard treatments. Topical interventions, together with or without radiotherapy, may only palliate the symptoms temporarily. However, there may be alternative treatment modalities for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy. There are various genetic alterations in tumors and therapeutic potential of expression patterns for factors like epidermal growth factor receptor may have important clinical implications in case of disease refractory to the conventional treatments. Here, we clarified the therapeutic options and genetic alterations in skin metastatic breast cancer patients refractory to standard chemotherapeutics.

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“…Further, heating of the prefrozen tissue caused much greater injury to tumor microvasculature, as reported by Shen et al [16,17]. Hachisuka et al [18] have combined cryosurgery with radiofrequency treatment for un-resectable breast cancer skin metastases that were resistant to chemotherapy and radiotherapy.…”

Section: Introductionmentioning

confidence: 89%

Study of enhanced radiofrequency heating by pre-freezing tissue

Zhang

Zou

et al. 2018

International Journal of Hyperthermia

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In our previous animal model study, we found that radiofrequency (RF) ablation of pre-frozen tumor resulted in improved therapeutic effects. To understand the underlying mechanisms and optimize the treatment protocol, the RF heating pattern in pre-frozen tissue was studied in this paper. Both ex vivo and in vivo experiments were conducted to compare the temperature profiles of RF heating with or without pre-freezing. Results showed that the heating rate of in vivo tissues was significantly higher with pre-freezing. However, little difference was observed in the heating rate of ex vivo tissues with or without pre-freezing. In the histopathologic analysis of in vivo tissues, both a larger ablation area and a wider transitional zone were found in the tissue with pre-freezing. To investigate the cause for the enhancement in RF heating, the parameters affecting the tissue temperature rise were studied. It was found that the electrical conductivity of in vivo tissue with pre-freezing was much higher at low frequencies, but little difference was found at the 460 kHz frequency commonly used in clinical applications. A finite element model for RF heating was developed and validated to fit the thermal conductivity of in vivo tissue including effects of pre-freezing and the associated blood perfusion rate. Results showed that the enhancement of the heating rate was primarily attributed to the decreased blood perfusion rate in the tissue with vascular damage caused by pre-freezing. The ablation volume was increased by 104% due to the reduced heat dissipation.

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Combination cryosurgery with hyperthermia in the management of skin metastasis from breast cancer: A case report

Abstract: [corrected] This treatment provides an alternative for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy.

Cited by 12 publications

References 5 publications

Perspectives of Breast Cancer Thermotherapies

Perspectives of Breast Cancer Thermotherapies

Anticancer Therapy for Breast Cancer Patients with Skin Metastases Refractory to Conventional Treatments

Study of enhanced radiofrequency heating by pre-freezing tissue

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