Anticancer Therapy for Breast Cancer Patients with Skin Metastases Refractory to Conventional Treatments

Abstract

Skin metastases of breast cancer are usually late events in the course of tumor progression and signify a poor prognosis. They may remain as a therapeutic challenge especially after failure of standard treatments. Topical interventions, together with or without radiotherapy, may only palliate the symptoms temporarily. However, there may be alternative treatment modalities for unresectable breast cancer skin metastases resistant to chemotherapy and radiotherapy. There are various genetic alterations in tumors and therapeutic potential of expression patterns for factors like epidermal growth factor receptor may have important clinical implications in case of disease refractory to the conventional treatments. Here, we clarified the therapeutic options and genetic alterations in skin metastatic breast cancer patients refractory to standard chemotherapeutics.

Dosimetric Evaluation of 3-D Conformal and Intensity-modulated Radiotherapy for Breast Cancer after Conservative Surgery

“…Nowadays, radiotherapy plays an important role in the treatment of breast cancer (Zhou et al, 2012;Liu et al, 2013;Nandi et al, 2014;Varol et al, 2014), and breastconserving surgery followed by adjuvant radiotherapy (RT) is now the standard treatment for early-stage breast cancer (Veronesi et al, 2002). It allows the reduction to local recurrence and metastases, so these patients survive for long periods of time, mortality and morbidity are RESEARCH ARTICLE…”

Fungal Taxol Extracted from Cladosporium oxysporum Induces Apoptosis in T47D Human Breast Cancer Cell Line

“…Besides a considerable part of the profits also been achieved by chemotherapy which depends on the activation of apoptosis in cancer cells. In tumor cells antiapoptotic proteins have been highly expressed and it is recognized as a key target point of anti-cancer therapeutic interventions (Varol et al, 2014) and their inhibitors at the levels of proteins and mRNA is developed (Yang et al, 2008). One of the major executioners of apoptosis is a set of cysteine proteases called caspases that are initially synthesized as inactive zymogens called procaspases.…”

An unexpected metastasis of breast cancer mimicking wheal rush

“…It is always required a skin biopsy for the diagnosis. The treatment includes cryotherapy, radiotherapy and chemotherapy, but the prognosis is usually poor (9,10).…”