Immunological profile of teeth with inflammatory periapical disease from chronic liver disease patients

Diniz, Julia Mourão Braga; Espaladori, Marcela Carvalho; Silva, M. E. Souza e; Brito, Luciana Carla Neves de; Vieira, Leda Quércia; Sobrinho, Antônio Paulino Ribeiro

doi:10.1111/iej.12992

Cited by 7 publications

(2 citation statements)

References 47 publications

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“…It was also observed presence of AP in one or more teeth in 46% of the patients with cirrhosis and association of AP with higher prevalence of complications related to cirrhosis, such as ascites, hepatic encephalopathy and/or variceal bleeding [109]. In another study, liver impairment did not compromise the periapical immune response [110]. Despite these findings, the available studies on oral infections do not allow us to establish a cause-effect relationship between AP and liver disease, as well as to substantiate the biological pathways involved in the interrelation between these diseases.…”

Section: Hepatic Diseasesmentioning

confidence: 87%

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Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

et al. 2021

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Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to evaluate the interrelationship between systemic and periapical tissues pathological conditions. These studies have shown that systemic changes can boost the pathogenesis of endodontic infection, favoring its development and progression. A contrary relationship is reported in numerous studies that affirm the potential of endodontic infection to trigger systemic damage and may lead to the worsening of pre-existing pathologies. Recently, the potential of filling materials to develop systemic changes such as neurological alterations had been evaluated, also showing that systemic diseases can negatively influence tissue responses to filling materials after endodontic treatment. Despite advances in endodontic medicine studies, there are still gaps in knowledge on the mechanisms of interactions between apical periodontitis (AP) and systemic diseases and much research to be done. In this sense, this critical narrative literature review aimed to show the evolution of studies in endodontic medicine to help the endodontist to know the role of systemic diseases in the pathogenesis of AP and the possible interference in the repair of periapical tissues after endodontic treatment, as well as to evidence the systemic complications that can be triggered or aggravated in the presence of endodontic infection.

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Section: Hepatic Diseasesmentioning

confidence: 87%

“…Regarding human studies, few studies have addressed this type of relationship and Table 3 summarizes the characteristics and main findings of clinical studies that assessed the association between endodontic parameters and hepatic disease [108][109][110], and other systemic diseases and conditions.…”

Section: Hepatic Diseasesmentioning

confidence: 99%