Immunological findings and respiratory function in cotton textile workers

Zuśkin, E; Kanceljak, B; En, Schachter; Tj, Witek; Mustajbegović, Jadranka; Maayani, Saul; Mg, Buck; Rienzi, N

doi:10.1007/bf00625948

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…The data illustrated by these studies are similar to those of our previous studies with different organic dust extracts such as coffee, soy, spices, animal food, poultry and swine confinement building dust, brewery dust (hops, barley, yeast), as well as textile dust (cotton, hemp and wool) [23][24][25][35][36][37][38][39][40][41][42]. The pharamcologic studies of paper dust extract on isoalted guinea pig tracheal smooth muscle suggest a complex effect of this airway irritant.…”

Section: Discussionsupporting

confidence: 73%

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Schachter

Zuśkin

Rienzi

et al. 1998

Lung

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The effect of paper dust collected at two different locations in a paper recycling plant (PD1 and PD2) on isolated nonsensitized guinea pig tracheal smooth muscle was studied in vitro. Dust extracts were prepared as a 1:10 w/v aqueous solution. Dose-related contractions of guinea pig tracheal rings were elicited with both PD1 and PD2. Pharmacologic studies were performed with atropine (10(-6) M), indometacin (10(-6) M), pyrilamine (10(-6) M), LY171883 (10(-5) M), nordihydroguaiaretic acid (10(-5) M), and TMB8 (10(-5) M). The possible role of endogenous neuropeptides in this constrictor process was studied by depleting neural mediators with capsaicin (5 x 10(-6) M) before challenge with dust extracts. Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. The intracellular calcium-blocking agent TMB8 also induced a reduction of the contractile responses to PD1 and PD2 consistent with the well established role of intracellular calcium in smooth muscle constriction. Pretreatment with capsaicin significantly increased the contractile activity of paper dust extracts but only at the higher doses of these extracts. This suggests that the effect of paper dust is not initiated by the release of mediators stored in sensory nerves but that the prerelease of these mediators may enhance the constrictor effects of these dusts. We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. The constrictor effect does not require tissue presensitization or the release of neuropeptides from sensory nerves.

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Section: Discussionsupporting

confidence: 73%

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Schachter

Zuśkin

Rienzi

et al. 1998

Lung

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“…The IgE level was not related to lung function changes, suggesting that IgE level might not be the basis for the airway obstruction observed in cotton workers. 24 A clear exposure-response relation was not observed for either acute or longitudinal pulmonary responses, though exposure to high dust was negatively related to lung function. Several possible explanations were considered.…”

Section: Discussionmentioning

confidence: 90%

A longitudinal observation of early pulmonary responses to cotton dust

Wang¹,

Pan²,

Zhang³

et al. 2003

Occup Environ Med

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Aims: To examine early adverse pulmonary effects of exposure to cotton dust, and to identify potential risk factors, including atopy for pulmonary responses to cotton dust. Methods: Spirometry, methacholine challenge testing, and questionnaire; performed among 101 nonsmoking newly hired textile workers at baseline (prior to starting work), and at 3, 12, and 18 months after starting work. Concentrations of airborne cotton dust in various work areas were measured at each follow up survey using vertical elutriators. Results: The incidence of non-specific respiratory symptoms was 8% at three months, then diminished afterwards. Substantial acute cross shift drops in FEV 1 at each follow up survey, and longitudinal declines in FVC and FEV 1 after 12 months of exposure were observed. Airway responsiveness to methacholine increased with follow up time, and was more pronounced among atopics. Increasing airway responsiveness was strongly correlated with cross shift drops in FEV 1 . In addition, one or more respiratory symptoms at three months was significantly, and pre-existing atopy marginally significantly, associated with cross shift drops in FEV 1 after adjusting for other covariates and confounders. Conclusion: Results suggest that non-specific respiratory symptoms, decreasing lung function, and increasing airway responsiveness are early pulmonary responses to cotton dust. In addition, the occurrence of respiratory symptoms and increasing airway responsiveness, as well as atopy, may be important predictors for acute changes in lung function among cotton textile workers.

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“…[19] A non-significant increase in Ig E levels of textile workers was also reported by Zuskin et al . [20]…”

Section: Resultsmentioning

confidence: 99%

Biochemical profile of gin women laborers in Tirupur

Jannet

Jeyanthi

2007

Indian J Occup Environ Med

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Ginning factories discharge large amounts of cotton dusts that lead to decreased pulmonary function in the exposed subjects. An attempt was made to study the biochemical profile of women laborers employed in ginning factory located in Tirupur, a textile based city in Coimbatore district of Tamilnadu, India. The blood parameters that were analyzed were hemoglobin, total and differential count of leucocytes, erythrocyte sedimentation rate (ESR), total proteins, immunoglobulins, total and isozymic content of lactate dehydrogenase (LDH) and histamine. Student's ‘t’ test was carried out to compare the results with the control women. Correlation analysis was done between/within the biochemical parameters and also between the pulmonary function parameters results reported earlier by Jannet and Jeyanthi. Significant changes in the levels of hemoglobin, ESR, immunoglobins and histamine were reported in this study. Correlation studies between the pulmonary function parameters and biochemical parameters revealed significant negative correlation of FVC, FEV1 and PEF with ESR (P <0.05). There was also positive correlation between immunoglobin G and histamine. A significant negative correlation was observed between LDH1 and LDH3 and between albumin and γ globulin. The study suggested that the ginning factory women laborers exhibited significant changes in the levels of certain biochemical parameters apart from the pulmonary functional changes.

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Immunological findings and respiratory function in cotton textile workers

Cited by 13 publications

References 35 publications

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

Effects of Recycled Paper Dust Extracts on Isolated Guinea Pig Trachea

A longitudinal observation of early pulmonary responses to cotton dust

Biochemical profile of gin women laborers in Tirupur

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