Immunological effects of stress in psoriasis

Schmid-Ott, ­Gerhard; Jaeger, Burkard; Boehm, Thomas; Langer, Katja; Stephan, Michael; Raap, Ulrike; Werfel, Thomas

doi:10.1111/j.1365-2133.2008.09013.x

Cited by 39 publications

(35 citation statements)

References 12 publications

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“…Psychological stress increased the numbers of CD3 + , CD8 + , CD16 + /CD56 + (i.e., NK cells), and CD3 + /HLA-DR leukocytes in the blood, although the differences between psoriatics and nonpsoriatics were insignificant [105]. Schmid-Ott et al evaluated circulating levels of T cells and NK cells in psoriatics and nonpsoriatic following experimental psychological stress [106]. In contrast to results obtained by Buske-Kirschbaum et al, levels of CD3 + T cells increased significantly only in the blood of psoriatics following psychological stress.…”

Section: Psychological Stress and Human Skin Diseasesmentioning

confidence: 99%

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Hall

Cruser

Podawiltz

et al. 2012

Dermatology Research and Practice

122

105

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Psychological stress, an evolutionary adaptation to the fight-or-flight response, triggers a number of physiological responses that can be deleterious under some circumstances. Stress signals activate the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Elements derived from those systems (e.g., cortisol, catecholamines and neuropeptides) can impact the immune system and possible disease states. Skin provides a first line of defense against many environmental insults. A number of investigations have indicated that the skin is especially sensitive to psychological stress, and experimental evidence shows that the cutaneous innate and adaptive immune systems are affected by stressors. For example, psychological stress has been shown to reduce recovery time of the stratum corneum barrier after its removal (innate immunity) and alters antigen presentation by epidermal Langerhans cells (adaptive immunity). Moreover, psychological stress may trigger or exacerbate immune mediated dermatological disorders. Understanding how the activity of the psyche-nervous -immune system axis impinges on skin diseases may facilitate coordinated treatment strategies between dermatologists and psychiatrists. Herein, we will review the roles of the HPA axis and the sympathetic nervous system on the cutaneous immune response. We will selectively highlight how the interplay between psychological stress and the immune system affects atopic dermatitis and psoriasis.

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Section: Psychological Stress and Human Skin Diseasesmentioning

confidence: 99%

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Hall

Cruser

Podawiltz

et al. 2012

Dermatology Research and Practice

122

105

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show abstract

“…The clinical severity of the psoriasis may not reflect the degree of emotional impact of the disease 22 . Psychological stress causes phenotypic changes in circulating lymphocytes and is regarded as an important trigger of the T‐helper 1 cell‐polarized inflammatory skin disease in psoriasis 23 Figure 1. shows the stress–response pathway involved in triggering psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Stress and quality of life in psoriasis: an update

2011

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Psoriasis is a chronic, relapsing, cutaneous condition with 1-2% prevalence in the general population. There are many factors involved in the induction and/or exacerbation of psoriasis of which stress is a well-known trigger factor in the appearance or exacerbation of psoriasis. Stress reaction in patients with psoriasis is probably mediated by the hypothalamic-pituitary-adrenal relationship with immunologic effects. Stress response involves increased levels of neuroendocrine hormones and autonomic neurotransmitters. Psychological stress or an abnormal response to stressors has been found to modify the evolution of skin disorders such as psoriasis. It can also have substantial psychological, and psychosocial impact on a patient's quality of life. Treatment regimens include stress-reduction strategies, such as biofeedback, meditation, yoga, and self-help approaches. This review focuses the relationship between psoriasis and stress, especially relating to psychosocial, psychological, and emotional stress aspects.

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“…In addition, some other research studies also described that the risk for having psoriasis increases significantly in patients who have moderate to severe depression [74,75,76]. Psychological stress has also been found to cause phenotypic changes in patients, potentially triggering psoriasis, and to have an association with CRP levels in women with psoriasis [77,78]. …”

Section: Bidirectional Inflammatory and Neurochemical Phenomenonmentioning

confidence: 99%

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid¹,

Aleem²,

Jackson³

2016

Skin Pharmacol Physiol

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Objective: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. Method: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. Results: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8. Conclusion: Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.

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Immunological effects of stress in psoriasis

Cited by 39 publications

References 12 publications

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Psychological Stress and the Cutaneous Immune Response: Roles of the HPA Axis and the Sympathetic Nervous System in Atopic Dermatitis and Psoriasis

Stress and quality of life in psoriasis: an update

Major Depression and Psoriasis: A Psychodermatological Phenomenon

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