Immunological determinants of implantation success

Robertson, Sarah A.; Moldenhauer, Lachlan M.

doi:10.1387/ijdb.140096sr

Cited by 108 publications

(97 citation statements)

References 159 publications

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“…Proper establishment, progress and success of mammalian pregnancy rely on the capability of the maternal immune system to undergo a series of adaptations tending to tolerate the presence of the semi-allogeneic fetus (Robertson and Moldenhauer, 2014;Seavey and Mosmann, 2008). Among others well described immune-mechanisms; our laboratory has demonstrated that pregnancy induces strong modifications in B cell development (Muzzio et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Bommer

Muzzio

Zygmunt

et al. 2016

Journal of Reproductive Immunology

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Please cite this article as: Bommer, I., Muzzio, D.O., Zygmunt, M., Jensen, F., ଝProgesterone and estradiol exert an inhibitory effect on the production of antiinflammatory cytokine IL-10 by activated MZ B cells.Journal of Reproductive Immunology http://dx.doi.org/10. 1016/j.jri.2016.05.008 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 2 AbstractThe main message of this work is the fact that female sex hormones, progesterone and estradiol, whose levels significantly rise during pregnancy, inhibit the production of anti-inflammatory cytokine IL-10 with no apparent effect on pro-inflammatory cytokine TNF-α by activated MZ B cells. This is an important piece of information and helps to better understand how the maternal immune system controls the balance between immune tolerance and immune activation during pregnancy leading to the simultaneously acceptance of the semi-allogeneic fetus and the proper defense of the mother against pathogens during this critical period of time.

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Section: Introductionmentioning

confidence: 99%

Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Bommer

Muzzio

Zygmunt

et al. 2016

Journal of Reproductive Immunology

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“…Moreover, the programmed cell death ligand (PDL1) is crucial for maternal tolerance in allogeneic pregnancies (2). Finally, the presence of regulatory T cells (Tregs) is instrumental to the maintenance of maternal tolerance (3), where fetus-specific Tregs remain after pregnancy (4) and can expand in subsequent pregnancies (5). Immune tolerance of the fetus relies on the concerted actions of hormones and cytokines, as well as cross-talk between innate and adaptive immune cells (6).…”

mentioning

confidence: 99%

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

Nadkarni

Sferruzzi‐Perri

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

118

117

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Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the induction of a population of CD4+ T cells displaying a GARP+CD127loFOXP3+ phenotype following antigen activation. Neutrophil-induced T (niT) cells produce IL-10, IL-17, and VEGF and promote vessel growth in vitro. Neutrophil depletion during murine pregnancy leads to abnormal development of the fetal-maternal unit and reduced empbryo development, with placental architecture displaying poor trophoblast invasion and spiral artery development in the maternal decidua, accompanied by significantly attenuated niT cell numbers in draining lymph nodes. Using CD45 congenic cells, we show that induction of niT cells and their regulatory function occurs via transfer of apoptotic neutrophil-derived proteins, including forkhead box protein 1 (FOXO1), to T cells. Unlike in women with healthy pregnancies, neutrophils from blood and placental samples of preeclamptic women fail to induce niT cells as a direct consequence of their inability to transfer FOXO1 to T cells. Finally, neutrophil-selective FOXO1 knockdown leads to defective placentation and compromised embryo development, similar to that resulting from neutrophil depletion. These data define a nonredundant function of neutrophil–T cell interactions in the regulation of vascularization at the maternal–fetal interface.

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“…It is assumed that in the decidua, the Tregs mainly fulfill immunosuppressive action [16]. Treg lymphocytes have anti-inflammatory and immunosuppressive effects [96], secrete IL-10, TGF-β, IL-4, IL-5 [32], express GATA3 ( Figure 1, Table 1) [29]. Treg lymphocytes inhibit proliferation and production of cytokines by T cells, production of immunoglobulins by B-cells, cytotoxic activity of NK-cells, DC maturation, and, thus, contribute to tolerance formation [104].…”

Section: Cd11bmentioning

confidence: 99%

“…Treg Тh3 subpopulation is characterized by TGF-β and IL-10 secretion and FoxP3 expression [87]. CD4 + CD25 -alteration into Treg cells at the periphery (outside the thymus) occurs with obligatory B7 molecule co-stimulation [61], at activation through TcR [35] in cooperation with action of IL-10 and TGF-β cytokines [42,109,121], the source of which is the trophoblast in the zone of the uteroplacental bed [17,29,96,120]. Estradiol promotes Treg differentiation and increases their proliferation in response to activation through CD3/CD28 [131].…”

Section: Cd25mentioning

confidence: 99%

“…For Treg-lymphocyte phenotyping, multiple nonstandard monoclonal antibody kits against both surface markers and transcription factors are used, which can be the reason of a big difference in the results ) count increased both in circulation [118], achieving its peak in the second trimester [52,56,112,131], and in zone of uteroplacental contact [87,96,108,125,143]. In the mouse model it has been found that Tregs increase in lymph nodes at pregnancy [142].…”

Section: Localization Of T Lymphocyte Subpopulations At Pregnancymentioning

confidence: 99%

See 1 more Smart Citation

THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4<sup>+</sup>Т LYMPHOCYTES DURING PREGNANCY

Игоревич¹,

Степанова²,

Selkov³

2016

Med. immunol.

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Immunological determinants of implantation success

Cited by 108 publications

References 159 publications

Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4<sup>+</sup>Т LYMPHOCYTES DURING PREGNANCY

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