Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Bommer, I.; Muzzio, Damián Oscar; Zygmunt, Marek; Jensen, Federico

doi:10.1016/j.jri.2016.05.008

Cited by 18 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B cells were first observed in the placental bed of women early in gestation, which was confirmed by later studies . During early pregnancy, B cells are implicated in the mechanisms of maternal‐fetal tolerance . Decidual B cells modestly increase between 27 and 33 weeks of gestation followed by a slight decline at term .…”

Section: Introductionmentioning

confidence: 60%

Are B cells altered in the decidua of women with preterm or term labor?

Leng

Romero²,

et al. 2019

American J Rep Immunol

View full text Add to dashboard Cite

Problem The immunophenotype of B cells at the maternal‐fetal interface (decidua) in labor at term and preterm labor is poorly understood. Method of study Decidual tissues were obtained from women with preterm or term labor and from non‐labor gestational age‐matched controls. Immunophenotyping of decidual B cells was performed using multicolor flow cytometry. Results (a) In the absence of acute or chronic chorioamnionitis, total B cells were more abundant in the decidua parietalis of women who delivered preterm than in those who delivered at term, regardless of the presence of labor; (b) decidual transitional and naïve B cells were the most abundant B‐cell subsets; (c) decidual B1 B cells were increased in women with either labor at term or preterm labor and chronic chorioamnionitis compared to those without this placental lesion; (d) decidual transitional B cells were reduced in women with preterm labor compared to those without labor; (e) naïve, class‐switched, and non–class‐switched B cells in the decidual tissues underwent mild alterations with the process of preterm labor; (f) decidual plasmablasts seemed to increase in women with either labor at term or preterm labor with chronic chorioamnionitis; and (g) decidual B cells expressed high levels of interleukin (IL)‐12, IL‐6, and/or IL‐35. Conclusion Total B cells are not increased with the presence of preterm or term labor; yet, specific subsets (B1 and plasmablasts) undergo alterations in women with chronic chorioamnionitis. Therefore, B cells are solely implicated in the pathological process of preterm labor in a subset of women with chronic inflammation of the placenta. These findings provide insight into the immunology of the maternal‐fetal interface in preterm and term labor.

show abstract

Section: Introductionmentioning

confidence: 60%

Are B cells altered in the decidua of women with preterm or term labor?

Leng

Romero²,

et al. 2019

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…B cells can also be recruited by the chorioamniotic membranes [14] and constitute a portion of the choriodecidual leukocytes [16,57,58]. The role of B cells during pregnancy and its complications have been widely studied by Jensen and collaborators [59][60][61][62][63][64][65][66][67][68]. Taken together, these data provide further evidence that the adaptive limb of immunity is involved in the process of labor.…”

Section: Resultsmentioning

confidence: 82%

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

et al. 2018

View full text Add to dashboard Cite

Prior to and during the process of human labor, maternal circulating leukocytes infiltrate the maternal-fetal interface (choriodecidua) and become activated resembling choriodecidual leukocytes. Since, there is no evidence comparing maternal circulating and choriodecidual leukocytes, herein, we characterized their transcriptome and explored the biological processes enriched in choriodecidual leukocytes. From women undergoing spontaneous term labor we isolated circulating and choriodecidual leukocytes, performed microarray analysis (n = 5) and qRT-PCR validation (n = 9) and interaction network analysis with up-regulated genes. We found 270 genes up-regulated and only 17 genes down-regulated in choriodecidual leukocytes compared to maternal circulating leukocytes. The most up-regulated genes were CCL18, GPNMB, SEPP1, FN1, RNASE1, SPP1, C1QC, and PLTP. The biological processes enriched in choriodecidual leukocytes were cell migration and regulation of immune response, chemotaxis, and humoral immune responses. Our results show striking differences between the transcriptome of choriodecidual and maternal circulating leukocytes. Choriodecidual leukocytes are enriched in immune mediators implicated in the spontaneous process of labor at term.

show abstract

“…Interaction of these inflammatory factors exacerbate inflammatory response, leading to the recruitment and infiltration of leukocytes in the liver and thereby aggravating microcirculation disorders [ 21 , 22 ]. Many studies have shown that up-regulation of TNF-α, IL-1β, and IL-6 could directly lead to organ damage by aggravating inflammatory response, and IL-10 could exert an inhibitory effect on inflammation [ 23 , 24 ]. Our results further confirmed these previous studies that significantly declined serum TNF-α, IL-1β, and IL-6 levels was occurred and serum IL-10 level was increased in hepatic ischemia–reperfusion rats by sevoflurane pre-conditioning, which effectively relieved hepatic ischemia–reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane relieves hepatic ischemia–reperfusion injury by inhibiting the expression of Grp78

Liu¹,

Jin²,

Zhang³

et al. 2018

Bioscience Reports

View full text Add to dashboard Cite

Purpose: This article aimed to study the role of sevoflurane pre-conditioning in hepatic ischemia–reperfusion and its potential mechanism.Methods: Rat liver ischemia–reperfusion model was constructed. Serum TNF-α, IL-1β, IL-10, and IL-6 concentrations were detected by ELISA. Malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) in liver homogenate were determined. Hematoxylin–Eosin (HE) staining, Tunel, and immunohistochemistry were performed. Ischemia–reperfusion hepatocyte model was established. Cells transfection was conducted. Apoptosis was observed by flow cytometry. Quantitative real-time PCR (qRT-PCR) and Western blotting analysis were used.Results: Compared with I/R group, liver damage degree, liver cell apoptosis, and glucose regulatory protein 78 (Grp78) expression was obviously reduced in rats of SEV group. TNF-α, IL-1β, and IL-6 concentrations were also significantly increased (P<0.01). MDA and NO concentrations were dramatically lower (P<0.01) and SOD concentration was significantly higher (P<0.01). Apoptosis rate, Grp78, PERK, eIF2α, and p-c-JNK/JNK expression was also significantly decreased (P<0.01). Sevoflurane significantly reduced apoptosis and expression of PERK, eIF2α, p-c-JNK/JNK by inhibiting the expression of Grp78 (P<0.01).Conclusion: Sevoflurane relieves hepatic ischemia–reperfusion injury by inhibiting the expression of Grp78.

show abstract

Progesterone and estradiol exert an inhibitory effect on the production of anti-inflammatory cytokine IL-10 by activated MZ B cells

Cited by 18 publications

References 14 publications

Are B cells altered in the decidua of women with preterm or term labor?

Are B cells altered in the decidua of women with preterm or term labor?

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

Sevoflurane relieves hepatic ischemia–reperfusion injury by inhibiting the expression of Grp78

Contact Info

Product

Resources

About