Immunological detection of faecal occult blood in colorectal cancer

Turunen, M; Liewendahl, K.; Partanen, Pirjo; Adlercreutz, Herman

doi:10.1038/bjc.1984.26

Cited by 61 publications

(22 citation statements)

References 27 publications

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“…Immunological tests for occult blood are specific for hemoglobin (Hb) derived from erythrocytes [24]. Chemical tests for fecal occult blood are sensitive, but false-positive reactions can be induced by the blood present in ingested meat and fish [12,25].…”

Section: Introductionmentioning

confidence: 99%

Carbonic Anhydorase Isoenzyme I (CA-I) Concentration in Feces and Urine as a Temporary Marker of Occult Blood in Beagle Dogs

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Carbonic Anhydorase Isoenzyme I (CA-I) Concentration in Feces and Urine as a Temporary Marker of Occult Blood in Beagle Dogs

et al. 2007

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“…A similar immunodiffusion technique with a detection limit of 5mg Hb lOOg-1 faeces, but using solutions of homogenised faeces, had 40/40 samples and 14/14 patients positive from carcinomas involving the colon (Williams et al, 1982). An ELISA technique with a detection limit of 5-10mg Hb lOOg-1 faeces, using homogenised 48 h faecal samples from patients with colorectal carcinoma had 93% (28/30) samples and 95% (18/19) patients positive (Turunen et al, 1984). Homogenisation of samples of I g or more of faeces, may be useful with hospital patients and some outpatients, but the inconvenience and loss of immunological reactivity of about 58-71% day-' (Frommer & Kapperis, 1983a) make it less suitable for mass screening of medium-risk subjects.…”

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Immunological detection of occult blood in bowel cancer patients

Kapparis¹,

Frommer²

1985

Br J Cancer

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Summary The ability of a highly sensitive gel immunodiffusion technique to detect faecal occult blood in control subjects and in patients with colorectal carcinoma, was compared to that of Hemoccult II. In 1,200 samples from 200 control subjects, 3.3% were positive by the immunological technique, 5.0% by Hemoccult II with rehydration and 2.3% without rehydration, representing 7.5%, 10.5% and 5.0% of subjects, respectively. A total of 2 carcinomas and 6 polyps were detected in the 27 positive subjects. (Doran & Hardcastle, 1982). The proportion of false negative results can be diminished by using kits of higher sensitivity or by preliminary rehydration of the faecal specimens, but both give an increased proportion of false positive results (Frommer & Logue, 1981;Winawer et al., 1980 Materials and methods SubjectsTwo hundred members of the general public (aged 61.6 +10.2y) who agreed to take part in bowel cancer screening studies and 40 patients with colorectal carcinomas (aged 67.0+12.1y), collected 6 faecal smears on filter paper from six bowel actions for immunological testing. During the last three bowel actions, Hemoccult II cards (containing two sample windows for each bowel action, giving a total of 6 samples per card) were also used. In order to reduce the numbers of false positive results with Hemoccult II, the subjects were asked to abstain from eating red meat (but chicken and fish

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“…Sir -The above paper by Turunen et al (1984) provides interesting data about the relative sensitivities of FECA-EIA, an immunological test for human haemoglobin (Hb), and four guaiac tests for the detection of faecal occult blood. The authors also present data on blood loss in 19 patients with colorectal cancer.…”

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confidence: 99%