Immunological Aspects of Dental Implant Rejection

Baseri, Milad; Radmand, Faraz; Hamedi, Reyhaneh; Yousefi, Mehdi; Kafil, Hossein Samadi

doi:10.1155/2020/7279509

Cited by 42 publications

(22 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For the BP terms, the DEGs were enriched in the immune response and inflammatory response, and this result was consistent with that of previous studies [ 37 ]. For the CC terms of GO, the DEGs were enriched in the integral component of the membrane, which included 68 DEGs.…”

Section: Discussionsupporting

confidence: 92%

“…The CXCL8, IL-6, and IL-1 β genes are directly involved in the cytokine-cytokine receptor interaction pathway (hsa04060). The hub gene IL-6 is a cytokine that stimulates immune response and is upregulated in peri-implantitis [ 37 ]. SPP1 is also known as OPN, and it is a type of osteoimmunoinflammatory marker related to the inflammation and regulation of cytokine production [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the regulatory mechanisms of MMP-9 in peri-implantitis need to be well elucidated. The LOX-1/MMP-9 signaling pathway and OPN may be potential drug targets to decrease the levels of proinflammatory cytokines and increase apoptosis in peri-implantitis [ 37 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools

Zhang

Wang²,

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Objectives. To investigate potential genetic biomarkers of peri-implantitis and target genes for the therapy of peri-implantitis by bioinformatics analysis of publicly available data. Methods. The GSE33774 microarray dataset was downloaded from the Gene Expression Omnibus (GEO). The differentially expressed genes (DEGs) between peri-implantitis and healthy gingival tissues were identified using the GEO2R tool. GO enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using the DAVID database and the Metascape tool, and the results were expressed as a bubble diagram. The protein-protein interaction network of DEGs was constructed using the Search Tool for the Retrieval of Interacting Genes (STRING) and visualized using Cytoscape. The hub genes were screened by the cytoHubba plugin of Cytoscape. The potential target genes associated with peri-implantitis were obtained from the DisGeNET database and the Open Targets Platform. The intersecting genes were identified using the Venn diagram web tool. Results. Between the peri-implantitis group and the healthy group, 205 DEGs were investigated including 140 upregulated genes and 65 downregulated genes. These DEGs were mainly enriched in functions such as the immune response, inflammatory response, cell adhesion, receptor activity, and protease binding. The results of KEGG pathway enrichment analysis revealed that DEGs were mainly involved in the cytokine-cytokine receptor interaction, pathways in cancer, and the PI3K-Akt signaling pathway. The intersecting genes, including IL6, TLR4, FN1, IL1β, CXCL8, MMP9, and SPP1, were revealed as potential genetic biomarkers and target genes of peri-implantitis. Conclusions. This study provides supportive evidence that IL6, TLR4, FN1, IL1β, CXCL8, MMP9, and SPP1 might be used as potential target biomarkers for peri-implantitis which may provide further therapeutic potentials for peri-implantitis.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools

Zhang

Wang²,

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Because macrophages are the primary phagocytes activated in the early inflammation stage when the body is exposed to implants [ 23 ], we used here THP-1 monocytes to investigate a potential toxicity of alloys or particles released from the degradation of dental implants, that could promote an activation of immune system. We compared the viability of THP-1 monocytes on polystryrene (CTRL) and S_TiNb surfaces.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

View full text Add to dashboard Cite

Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted. This study was designed to explore the biocompatibility of smooth titanium-niobium alloy (S_TiNb) versus smooth titanium commercially pure (S_TiCp)—a reference in implantology. All experiments were performed in vitro using human osteoblast-like SaOs-2 and monocyte THP-1 cell lines as models. Cell adhesion and growth morphology were determined by scanning electron microscopy, while cell viability was evaluated using WST-1 assay. Because niobate anions or niobium nanoparticles can be released from implants during biomaterial-cell interaction, potential immunotoxicity of potassium niobate (KNbO3) salt was evaluated by examining both metabolic activity and transcriptomic profiling of treated THP-1 monocytes. The main findings of this study are that S_TiCp and S_TiNb discs do not show an impact on the proliferation and viability of SaOs-2 cells compared to polystyrene surfaces, whereas a significant decrease in THP-1 cells’ viability and metabolic activity was observed in the presence of S_TiNb discs compared to the control group. However, no significant changes were found neeither at the metabolic activity nor at the transcriptomic level of THP-1 monocytes exposed to KNbO3 salt, suggesting that niobium has no effect on the immune system. Overall, these data imply a possible toxicity of S_TiNb discs toward THP-1 cells, which may not be directly related to niobium but perhaps to the manufacturing process of titanium- niobium alloy. Thus, this limitation must be overcome to make titanium alloy an excellent material for medical applications.

show abstract

“…Hotchkiss et al [ 36 , 37 ] have shown that macrophages are particularly important to this response, ultimately driving the conclusion of the inflammatory phase and recruiting mesenchymal stem cells (MSCs) to begin the reparative phase or recruiting other inflammatory cells to delay the healing response [ 38 , 39 ]. In fact, the polarized subtypes of macrophages have no certain advantages and disadvantages to tissue repair; for example, the formation of the vascular network can promote bone tissue regeneration, while the initiation of angiogenesis depends on M1 macrophages, while M2 macrophages play a role in promoting angiogenesis [ 40 – 42 ]. In addition, a too long polarization period of M1 macrophages will lead to an increase in the number of M2 macrophages, resulting in increased secretion of fibronectin, resulting in fiber wrapping on the surface of the implant and affecting the attachment of osteocytes to the surface of the implant [ 43 – 45 ].…”

Section: Classical Dichotomy Model Of Macrophagesmentioning

confidence: 99%

Classical Dichotomy of Macrophages and Alternative Activation Models Proposed with Technological Progress

Wei

Wang

et al. 2021

BioMed Research International

View full text Add to dashboard Cite

Macrophages are important immune cells that participate in the regulation of inflammation in implant dentistry, and their activation/polarization state is considered to be the basis for their functions. The classic dichotomy activation model is commonly accepted, however, due to the discovery of macrophage heterogeneity and more functional and iconic exploration at different technologies; some studies have discovered the shortcomings of the dichotomy model and have put forward the concept of alternative activation models through the application of advanced technologies such as cytometry by time-of-flight (CyTOF), single-cell RNA-seq (scRNA-seq), and hyperspectral image (HSI). These alternative models have great potential to help macrophages divide phenotypes and functional genes.

show abstract

Immunological Aspects of Dental Implant Rejection

Cited by 42 publications

References 86 publications

Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools

Identification of Potential Genetic Biomarkers and Target Genes of Peri-Implantitis Using Bioinformatics Tools

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

Classical Dichotomy of Macrophages and Alternative Activation Models Proposed with Technological Progress

Contact Info

Product

Resources

About