Immunological aspects in the rejection process of Hymenolepis muris-sylvaticae from CFLP and NMRI mice

Abstract

When mice were treated with 1–25 mg cortisone acetate thrice weekly, recovery of Hymenolepis murissylvaticae was significantly higher than in untreated controls, both in oral infections with six cysticercoids and surgical transplantations of one 7-day or 8-day-old worm. Cortisone treatment also resulted in the worms being located more anteriorly in the small intestine. Evidence of an immunological response against the tapeworm in the intestine is given by: (a) an accelerated rejection of a secondary oral cysticercoid infection and a significant difference of the dry weights of the worms recovered on day 10 in CFLP mice; (b) an accelerated rejection of a secondary surgical infection on days 4 and 6 in CFLP mice and on days 3 and 4 in NMRI mice; (c) an accelerated rejection of a secondary surgical infection given 3 and 6 months after the primary immunizing infection in SWlSS-albino mice.

Hymenolepis murissylvatici: humoral response in intestinal lavages of the mouse

“…Previous studies have indicated that the intestinal parasite Hymenolepis murissylvatici is rejected by an immunological reaction. Evidence for an immunological response to the tapeworm in the intestine is provided by an accelerated rejection of a secondary oral cysticercoid infection and a significant difference between the dry weights of the worms recovered on day 10 after infection and reinfection in CFLP mice (VAN HAEREN & DE RYCKE, 1986). This reaction is coupled with a humoral response in serum (VAN DER VORST et al, 1985).…”

“…Just like the better known H. diminuta (HOPKINS etal., 1972), H. murissylvatici is immunologically rejected by the mouse (VAN HAEREN & DE RYCKE, 1986). Twelve days after a primary infection of CFLP mice with H. murissylvatici 58% of the host animals were parasite free, while ten days after reinfection as many as 77% of the mice were parasite free.…”