Hymenolepis muris-sylvaticae and H. microstoma: Immunological cross-reaction in mice

Haeren, C. Van; Vorst, Emiel van der; Vliegher, L. De; Rycke, P. H. De

doi:10.1016/0014-4894(88)90105-1

Cited by 2 publications

(1 citation statement)

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“…H . diminuta, H. microstoma) in the definitive mouse host is effective against the lumen phase of the closely related hymenolepidid species (Hopkins, Goodall & Zajac 1977, Alghali & Grencis 1986, Ito & Onitake 1987a, Van Haeren et al 1988, Ito, Onitake & Andreassen 1988b. In the H .…”

Section: Introductionmentioning

confidence: 99%

Stage–specific antigens of Hymenolepis microstoma recognized in BALB/c mice

Ito

Itoh

Andreassen

et al. 1989

Parasite Immunology

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Antigenicity of eggs (oncospheres), cysticercoids and adults (with immature segments only) of the bile duct tapeworm Hymenolepsis microstoma was analysed using immunoblotting techniques and indirect immunofluorescent antibody (IFA) techniques with immune sera of BALB/c mice (i) infected with different doses of cysticercoids, (ii) during patent or prepatent infection with the lumen phase of the parasite or (iii) sensitized with live or dead eggs. Antibody responses detected by IFA test and immunoblotting showed that antigenicity of eggs (oncospheres) differed from that of cysticercoids and adults. Single worm infections were sufficient to stimulate antibody responses. Mice which had patent infection showed strong antibody responses to all three (egg (oncosphere), cysticercoid, adult) antigens, while mice given two prepatent infections showed some antibody responses to cysticercoid and adult antigens only. Although the normal intermediate hosts of this parasite are arthropods, antibodies to some major egg (oncosphere) antigens were produced in mice given eggs of this parasite orally, either through inoculation of eggs or ingestion of faeces contaminated with eggs. Antibodies were not produced in mice dosed with non-viable eggs. The results are consistent with the hypothesis that cestode parasites express phase- (or stage-) specific antigens.

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Section: Introductionmentioning

confidence: 99%