Immunological Approaches to Prevent Neuronal Apoptosis During Neuroinflammation

Murphy, Finbarr J; Keating, Katherine E.; Sheehan, David; Hayes, Ian

doi:10.2174/1568014054546263

Cited by 2 publications

(2 citation statements)

References 166 publications

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“…[53,54] Simultaneous occurrence of neuroinflammation and cell apoptosis in the CNS makes it difficult to uncover which one is the primary or secondary event. [55] Moreover, blood brain barrier is disrupted in inflammatory reactions in the brain. This permits entry of inflammatory to the brain parenchyma.…”

Section: Discussionmentioning

confidence: 99%

Daily Low Dose of Erythropoietin and Neuroinflammation

Nejat¹,

As²,

Ebrahimi³

et al. 2020

Preprint

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Neuroinflammation, defined as inflammatory reactions mediated by cytokines, chemokines, reactive oxygen species, and secondary messengers in the central nervous system (CNS) including the brain and spinal cord is the basis of many neurological disorders [1] Recently, erythropoietin (EPO) has been considered and studied as a modulator of neuroinflammation.[2-4] On this article minireview of pathophysiology of neuroinflammation and the neuroprotective effects of EPO is discussed and a case of subacute huge subdural hematoma with double mydriasis operated urgently, treated with low daily dose (vs high dose once or twice a month in the literature) of EPO and recovered fully and discharged home with good consciousness is reported. In addition, the probable outcome of erythropoietin administration in patients with neuroinflammation in COVID19 is considered.

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Section: Discussionmentioning

confidence: 99%

Daily Low Dose of Erythropoietin and Neuroinflammation

Nejat¹,

As²,

Ebrahimi³

et al. 2020

Preprint

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“…Survival of pathologic cells (for example cells which are precancerous, infected or those that could elicit autoimmune response) may contribute to cancer, inflammation and autoimmune diseases. On the other hand, removal of essential cells through excessive apoptosis contributes to the pathogenesis of some degenerative diseases [6][7][8] components is therefore, a useful therapeutic approach to counteract either unwanted survival or death of particular cells associated with certain human diseases [9][10][11]. Most apoptotic pathways converge on the proteolytic activation of members of a family of cysteine aspartyl-specific proteases, (caspases).…”

Section: Introductionmentioning

confidence: 99%

The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer

Booy¹,

Johar²,

Kadkhoda³

et al. 2005

CMCAIAA

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This short review was designed to draw the readership's attention to the following articles in the volume. Instead of providing a full summary of topics such as ageing of the immune system and the role of the immune system in ageing, the role of the immune system in the development of cancer and neurodegenerative diseases, it signalizes these topics and provides links to articles that follow as well as to other available literature. Our intention was to provide a new perspective and strengthen the associations between inflammation, cancer, neuro-degenerative diseases, ageing and autoimmunity. The relationship between inflammation, oxidative stress, apoptosis, neurodegeneration and cancer is already, to a certain extent mirrored by attempts of the pharmacologic industry to cross-apply our current knowledge from these fields to develop new treatment modalities. For instance, strategies that modulate cellular redox potential are being applied to restrain inflammation (antioxidants), or to kill cancer cells (prooxidants). Activation of apoptosis or attenuation of resistance of transformed cells towards cell death induction is perhaps the most promising direction chosen by many pharmaceutical companies to develop new classes of drugs. Furthermore, rapidly developing areas of immunology and virology, combined with the tremendous progress in the field of cancer biology and pharmacogenomics, may lead to the occurrence of an unique treatment, based on anti-cancer viral vectors and even anti-inflammatory strategies, which combine multiple pharmacologic activities in a single bio-molecule.

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Immunological Approaches to Prevent Neuronal Apoptosis During Neuroinflammation

Cited by 2 publications

References 166 publications

Daily Low Dose of Erythropoietin and Neuroinflammation

Daily Low Dose of Erythropoietin and Neuroinflammation

The Immune System, Involvement in Neurodegenerative Diseases, Ageing and Cancer

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