Daily Low Dose of Erythropoietin and Neuroinflammation

Abstract

Neuroinflammation, defined as inflammatory reactions mediated by cytokines, chemokines, reactive oxygen species, and secondary messengers in the central nervous system (CNS) including the brain and spinal cord is the basis of many neurological disorders [1] Recently, erythropoietin (EPO) has been considered and studied as a modulator of neuroinflammation.[2-4] On this article minireview of pathophysiology of neuroinflammation and the neuroprotective effects of EPO is discussed and a case of subacute huge subdural hematoma with double mydriasis operated urgently, treated with low daily dose (vs high dose once or twice a month in the literature) of EPO and recovered fully and discharged home with good consciousness is reported. In addition, the probable outcome of erythropoietin administration in patients with neuroinflammation in COVID19 is considered.

Daily Low Dose of Erythropoietin in Neuroinflammation; EPO Might Be Hazardous in COVID-19

“…The beneficial effects of EPO on neuroinflammation have been discussed on a growing amount of literature in the last three decades. [70][71][72][73] Fetal brain in rats exhibits high level of EPO receptor (EPO-R) which decreases after birth up to 100fold. EPO-R can be found on neurons, astrocytes and microglia in the adults, as well.…”