Immunological Abnormalities in the Pathogenesis of Inflammatory Bowel Disease

Hisamatsu, Tadakazu; Mikami, Yohei; Matsuoka, Katsuyoshi; Kanai, Takanori; Hibi, Toshifumi

doi:10.5217/ir.2012.10.4.317

Cited by 3 publications

(4 citation statements)

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“…Although the mechanisms underlying the pathogenesis of IBD have not been elucidated fully, it is possible that an uncontrolled immune response may give rise to chronic inflammation of the intestines 1,2. It is important to note that chronic inflammation has been associated with cardiovascular disease14,15 and that these findings have been reported from patients with SLE2 and RA 15,16,17.…”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that chronic inflammation has been associated with cardiovascular disease14,15 and that these findings have been reported from patients with SLE2 and RA 15,16,17. However, the occurrence of early atherosclerosis in patients with IBD differs between studies conducted in Western countries.…”

Section: Discussionmentioning

confidence: 99%

“…Environmental, genetic, and immunologic factors, as well as microvasculature abnormalities, may be associated with the pathogenesis of the disease, and abnormal intestinal immune responses result in inflammation in patients with genetic susceptibilities. 1 , 2 , 3 Several chronic systemic inflammatory diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), are associated with the development of atherosclerosis. 4 , 5 In these diseases, atherothrombotic complications are among the most important causes of mortality and morbidity.…”

Section: Introductionmentioning

confidence: 99%

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Does Carotid Intima-Media Thickness Increase in Patients With Inflammatory Bowel Disease?

2014

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Background/AimsMesenteric microvascular thrombosis has been implicated as a contributing factor to the pathogenesis of inflammatory bowel disease (IBD). The aim of the current study was to assess the possibility of subclinical atherosclerosis in patients with IBD by measuring their carotid intima-media thickness (c-IMT).MethodsThirty-eight patients with IBD who were followed-up for at least 3 years participated. Patients with a history of cardiovascular disease and known risk factors for atherosclerosis were excluded. As a control group, 38 healthy patients matched for age and gender without atherosclerosis risk factors were included. Carotid ultrasonography was performed in all patients and controls. Patient baseline characteristics and laboratory parameters were recorded to evaluate atherosclerosis risk factors.ResultsThe mean age of patients with IBD was 38.5±6.62 years. Twenty-three patients with IBD were diagnosed with ulcerative colitis and the other 15 cases were diagnosed with Crohn's disease. The median duration of disease was 52.0 months. Serologic markers such as erythrocyte sedimentation rate, C-reactive protein (CRP), and cholesterol levels differed significantly, however, there was no significant difference in c-IMT between patients with IBD and those in the control group (0.53±0.10 mm vs. 0.53±0.07; P=0.85). Multivariate analysis revealed that body mass index, CRP, disease duration, and age were significantly correlated with c-IMT in patients with IBD.ConclusionsThe results of the current study did not show an increase in c-IMT in patients with IBD. Further studies that include more subjects and a longer follow-up period will be necessary in order to evaluate the risk of atherosclerosis in Korean patients with IBD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Does Carotid Intima-Media Thickness Increase in Patients With Inflammatory Bowel Disease?

2014

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“…Understanding of the pathogenesis of IBD is essential for identifying several key points at which intestinal inflammation can be modulated and expanding our treatment options for IBD. The pathogenesis of the disease involves the complex interactions between genetic factors 14) , environmental factors 15 , 16) such as commensal intestinal bacteria, and immunological factors 17) . The discordance of IBD among monozygotic twins 18) and the increased incidence of IBD among immigrants to high-prevalence countries indicate an important role of environmental factors in the development of IBD.…”

Section: How Does Ibd Develop?mentioning

confidence: 99%

Current issues of pediatric inflammatory bowel disease in Korea

Kim

2014

Korean J Pediatr

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Inflammatory bowel disease (IBD) is a chronic relapsing disorder of unknown etiology, which is believed to be multifactorial. Recently, the incidence of pediatric IBD has steeply increased in Korea since 2000. Poorly controlled disease activity can result in complications such as intestinal fistulae, abscess, and stricture, as well as growth retardation and delayed puberty in children. Because of a lack of confirmative tests, various diagnostic modalities must be used to diagnose IBD. Onset age, location, behavior, and activity are important in selecting treatments. Monogenic IBD must be excluded among infantile and refractory very-early-onset IBD. Early aggressive therapy using biologics has recently been proposed for peripubertal children to prevent growth failure and malnutrition.

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