Immunologic components in human milk and allergic diseases with focus on food allergy

Burris, Amy D.; Pizzarello, Catherine; Järvinen, Kirsi M.

doi:10.1016/j.semperi.2020.151386

Cited by 15 publications

(19 citation statements)

References 81 publications

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“…There are many studies that show the benefits of breastfeeding for the infant include a reduced risk of developing atopy, asthma, and other immune-mediated diseases. Breastfeeding protects against the development of atopic disease, and this effect appears even stronger in children with atopic heredity [ 4 , 5 ]. The American Academy of Pediatrics Committee on Nutrition published a clinical update in 2019 that provided information on the relationship between breastfeeding and atopy, concluding that breastfeeding provides a protective effect against atopic dermatitis by at least during the first two years of life [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

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The functionality of breast milk in terms of immunity is well-known. Despite this, a significant proportion of breastfed infants exhibit sensitization to different potentially allergenic proteins and clinical reactivity (including anaphylaxis) early in life and before the introduction of complementary feeding for the first time. The potential induction of early oral tolerance to overcome early allergic sensitization through exposure to allergens in breast milk also remains controversial and not yet well-established. The objective of this scoping review is to provide a critical appraisal of knowledge about the content of cow’s milk antigens in human milk. The amount of dietary derived milk antigens found in human milk and the analytical methodologies used to detect and quantify these antigens, the allergic status of the mother, the stage of lactation, the time of sampling (before or after ingestion of food), and the impact of human milk allergen on the infant were the outcomes that were assessed. Allergy risk was explored in all reviewed studies and could help to better elucidate its role in the context of allergic disease development. According to the included literature, we can conclude that there are mainly fragments derived from bovine proteins in human milk, and the presence of potentially allergenic molecules is greater in the milk of mothers with an allergic tendency. A clear relationship between maternal diet and allergen content in breast milk could not be firmly concluded though. Also, infants receiving milk from human milk banks, where donor milk is pasteurized for preservation, may be subject to greater risk of allergy development, especially for β-lactoglobulin.

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Section: Introductionmentioning

confidence: 99%

Cow’s Milk Antigens Content in Human Milk: A Scoping Review

Franco

Fente

Sánchez

et al. 2022

Foods

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“…Immune response plays important roles in infants, especially innate immune response in newborns since adaptive immune response is not well-developed yet. The function of HM as a complementary immune system for newborns has been previously reported ( 34 ). From our identified protein ( Supplementary Table 1 ), above 54 proteins were enriched as innate immune response in biological process with p -value 1.6 x 10 −10 .…”

Section: Discussionmentioning

confidence: 87%

Comparative Proteomics of Human Milk From Eight Cities in China During Six Months of Lactation in the Chinese Human Milk Project Study

Sari

Pan²,

Zhang

et al. 2021

Front. Nutr.

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Human milk (HM) is the golden standard of infant nutrition that can protect immature body function and enhance nutrition metabolism to ensure infant growth. Region specificity and lactation period could change the protein composition in HM. In this research, proteomics analysis was used to compare proteomes across eight cities, namely Harbin, Lanzhou, Guangzhou, Chengdu, Jinhua, Weihai, Zhengzhou, and Beijing, which represented the northeast, northwest, southeast, southwest, east, and north and central regions of China,. Proteins varied significantly among the cities. These different proteins were mainly involved in the process of platelet degranulation, innate immune response, and triglyceride metabolic process, which might be due to different living environments. These differences also lead to variation in protection and fat metabolism from mothers to infants in different cities. Four proteins were expressed differently during 6 months of lactation, namely Dipeptidyl peptidase 1, Lysozyme C, Carbonic anhydrase 6, and Chordin-like protein 2. The changes in these proteins might be because of the change of growth needs of the infants. The findings from our results might help to improve the understanding of HM as well as to design infant formula.

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“…Most food allergens have been detected in amniotic fluid, 19 and this initial allergen encounter during fetal life is likely to play an important role in initiating the development of tolerance or sensitization toward food allergens. Similarly, cow's milk, peanut, wheat, and hen's egg proteins have been detected in human milk, albeit at varying frequency and levels, 20 thus highlighting another potential means of exposure for the infant. The largest body of evidence related to maternal antigen consumption and later FA risk is related to peanut consumption, 21 although results vary.…”

Section: Maternal Antigen Consumption During Pregnancy and Lactationmentioning

confidence: 99%

“…Human milk (HM) is recognized for its beneficial impact on both maternal and infant health; however, findings from studies evaluating the protective effect of breastfeeding against FA are mixed. 20,21 Although a recent clinical report from the AAP concluded that exclusive breastfeeding for at least 3 months is protective against early wheeze and decreases risk for AD, data were insufficient to suggest whether breastfeeding prevents or delays FA. 23 Differing definitions of breastfeeding and the actual composition of HM likely contribute to the contradictory findings.…”

Section: Breast-and Formula Feedingmentioning

confidence: 99%