1991
DOI: 10.1111/j.1600-051x.1991.tb00100.x
|View full text |Cite
|
Sign up to set email alerts
|

Immunohistological study of neuronal markers in inflamed gingiva obtained from children with Down's syndrome

Abstract: The histological appearance of the gingiva in children with Down's syndrome (DS) was studied with special reference to inflammatory involvement and innervation. A dense infiltration of inflammatory cells was seen in the propria of most of the DS patients, including a few polymorphonuclear leucocytes. A hyperplasia of the epithelium was also found. The innervation of the gingiva was studied using immunohistochemistry. Nerve fibers as well as nerve bundles immunoreactive to neurofilament (NF) were seen in the pr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

1
11
0

Year Published

1995
1995
2019
2019

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 13 publications
(12 citation statements)
references
References 50 publications
(39 reference statements)
1
11
0
Order By: Relevance
“…One of the requirements for neuronal stromal cell interaction is close association between neuronal fibers and stromal cells. It has been shown in other tissues that inflammation can lead to nerve fiber sprouting [22][23][24]. Intriguingly, we show that there is sparse neuronal innervation of the healthy mucosa, which dramatically increases as a result of inflammation.…”
Section: Discussionsupporting
confidence: 52%
“…One of the requirements for neuronal stromal cell interaction is close association between neuronal fibers and stromal cells. It has been shown in other tissues that inflammation can lead to nerve fiber sprouting [22][23][24]. Intriguingly, we show that there is sparse neuronal innervation of the healthy mucosa, which dramatically increases as a result of inflammation.…”
Section: Discussionsupporting
confidence: 52%
“…inappropriate regulation of enzymes and T cell immunodeficiency [8] together with the functional defects of polymorphonuclear leucocytes and monocytes already highlighted [9]. These factors, together with the possibility of differences in collagen biosynthesis, abnormal capillary morphology [8] and hyperinnervation of the gingivae [10], may contribute to the rapid periodontal destruction observed in these patients.…”
Section: Introductionmentioning
confidence: 99%
“…It is also well documented that the parasympathetic fibers contain VIP, which is released at their termination (Fahrenkrug et al, 1978;Lundberg, 1981). The presence of VIP fibers was demonstrated in human and rat gingiva and lip (Luthman et al, 1988;Barr-Agholme et al, 1991). These data suggest that VIP fibers not only innervate vessels in the gingiva and vessels and glands in the lip, but it may also influence T-cells.…”
Section: Discussionmentioning
confidence: 92%