Immunohistological expression of oestrogen receptor, progesterone receptor, mammaglobin, human epidermal growth factor receptor 2 and GATA‐binding protein 3 in non‐small‐cell lung cancer

Kriegsmann, Katharina; Zgorzelski, Christiane; Muley, Thomas; Christopoulos, Petros; Winterfeld, Moritz von; Herpel, Esther; Goeppert, Benjamin; Mechtersheimer, Gunhild; Sinn, Hans‐Peter; Schirmacher, Peter; Winter, Hauke; Eichinger, Monika; Warth, Arne; Kriegsmann, Mark

doi:10.1111/his.14203

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…Блокирование эстрогеновых рецепторов, результатом которого является угнетение пролиферации опухолевых клеток, уже давно успешно применяется при терапии рака молочной же-лезы, а антиэстроген тамоксифен на протяжении более 50 лет является золотым стандартом адъювантного лечения этого заболевания [6]. Трансляционные исследования доказали наличие экспрессии ER в ткани НМРЛ [7,8], следовательно, можно предположить, что приём антиэстрогенов в комбинации с другими препаратами может быть эффективен при данном заболевании. Стоит также отметить положительные стороны гормонотерапии: лекарственные препараты обычно хорошо переносятся, доступны и отличаются невысокой ценой по сравнению с таргетными лекарственными средствами.…”

Section: Introductionunclassified

Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease

Богуш

Samsonik

Башарина

et al. 2021

A&Ch

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The expression level of estrogen receptors (ERα and ERβ) in surgical tumor biopsy specimens from 167 patients with non-small cell lung cancer (NSCLC) was quantiﬁed by ﬂow cytometry-based immunoﬂuorescence analysis. ERα and ERβ expression was revealed in all the tumor samples investigated. The level of ERα expression in the tumors varied from 10 to 58% and ERβ — 12% to 80%, indicating signiﬁcant heterogeneity of estrogen receptor expression in tumors of diﬀerent patients. The mean ERβ expression level was approximately 2-times higher compared to ERα (42.1±15.3% vs 21.4±11.3%; p<0.001). It allows to consider ER>β as a major estrogen target in NSCLC tissue. The level of ERα and ERβ expression in NSCLC tissue is independent of gender, smoking status, and the histological type of the tumor. Increased ERβ expression was detected only in male patients with lung adenocarcinoma in comparison with squamous cell carcinoma (p=0.02). The assessment of the correlation between ERα and ERβ in both the whole cohort of patients and subgroups with clinically relevant disease parameters revealed that the level of one marker does not predict the other one’s expression. The coeﬃcient of determination, which characterizes how diﬀerences in one variable can be explained by the diﬀerence in a second variable, was less than 25% in any comparison group. The authors consider that the high level of ERβ expression and ERα coexpression in NSCLC tissue substantiates the clinical perceptiveness of a new treatment option for the disease, namely, adjuvant hormone (antiestrogen) therapy.

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Section: Introductionunclassified

Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease

Богуш

Samsonik

Башарина

et al. 2021

A&Ch

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Elucidating shared biomarkers in gastroesophageal reflux disease and idiopathic pulmonary fibrosis: insights into novel therapeutic targets and the role of angelicae sinensis radix

Wu,

Xiao,

Fang

et al. 2024

Front. Pharmacol.

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Background: The etiological underpinnings of gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) remain elusive, coupled with a scarcity of effective therapeutic interventions for IPF. Angelicae sinensis radix (ASR, also named Danggui) is a Chinese herb with potential anti-fibrotic properties, that holds promise as a therapeutic agent for IPF.Objective: This study seeks to elucidate the causal interplay and potential mechanisms underlying the coexistence of GERD and IPF. Furthermore, it aims to investigate the regulatory effect of ASR on this complex relationship.Methods: A two-sample Mendelian randomization (TSMR) approach was employed to delineate the causal connection between gastroesophageal reflux disease and IPF, with Phennoscanner V2 employed to mitigate confounding factors. Utilizing single nucleotide polymorphism (SNPs) and publicly available microarray data, we analyzed potential targets and mechanisms related to IPF in GERD. Network pharmacology and molecular docking were employed to explore the targets and efficacy of ASR in treating GERD-related IPF. External datasets were subsequently utilized to identify potential diagnostic biomarkers for GERD-related IPF.Results: The IVW analysis demonstrated a positive causal relationship between GERD and IPF (IVW: OR = 1.002, 95%CI: 1.001, 1.003; p < 0.001). Twenty-five shared differentially expressed genes (DEGs) were identified. GO functional analysis revealed enrichment in neural, cellular, and brain development processes, concentrated in chromosomes and plasma membranes, with protein binding and activation involvement. KEGG analysis unveiled enrichment in proteoglycan, ERBB, and neuroactive ligand-receptor interaction pathways in cancer. Protein-protein interaction (PPI) analysis identified seven hub genes. Network pharmacology analysis demonstrated that 104 components of ASR targeted five hub genes (PDE4B, DRD2, ERBB4, ESR1, GRM8), with molecular docking confirming their excellent binding efficiency. GRM8 and ESR1 emerged as potential diagnostic biomarkers for GERD-related IPF (ESR1: AUCGERD = 0.762, AUCIPF = 0.725; GRM8: AUCGERD = 0.717, AUCIPF = 0.908). GRM8 and ESR1 emerged as potential diagnostic biomarkers for GERD-related IPF, validated in external datasets.Conclusion: This study establishes a causal link between GERD and IPF, identifying five key targets and two potential diagnostic biomarkers for GERD-related IPF. ASR exhibits intervention efficacy and favorable binding characteristics, positioning it as a promising candidate for treating GERD-related IPF. The potential regulatory mechanisms may involve cell responses to fibroblast growth factor stimulation and steroidal hormone-mediated signaling pathways.

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Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

Musiał

Zaucha

Kuban–Jankowska

et al. 2021

IJERPH

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Malignant neoplasms are among the most common diseases and are responsible for the majority of deaths in the developed world. In contrast to men, available data show a clear upward trend in the incidence of lung cancer in women, making it almost as prevalent as breast cancer. Women might be more susceptible to the carcinogenic effect of tobacco smoke than men. Furthermore, available data indicate a much more frequent mutation of the tumor suppressor gene-p53 in non-small cell lung cancer (NSCLC) female patients compared to males. Another important factor, however, might lie in the female sex hormones, whose mitogenic or carcinogenic effect is well known. Epidemiologic data show a correlation between hormone replacement therapy (HRT) or oral contraceptives (OCs), and increased mortality rates due to the increased incidence of malignant tumors, including lung cancer. Interestingly, two types of estrogen receptors have been detected in lung cancer cells: ERα and ERβ. The presence of ERα has been detected in tissues and non-small-cell lung carcinoma (NSCLC) cell lines. In contrast, overexpression of ERβ is a prognostic marker in NSCLC. Herein, we summarize the current knowledge on the role of estrogens in the etiopathogenesis of lung cancer, as well as biological, hormonal and genetic sex-related differences in this neoplasm.

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Immunohistological expression of oestrogen receptor, progesterone receptor, mammaglobin, human epidermal growth factor receptor 2 and GATA‐binding protein 3 in non‐small‐cell lung cancer

Cited by 5 publications

References 56 publications

Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease

Correlation of quantitative measures of estrogen receptor α and β expression in non-small cell lung cancer tissue with clinical characteristics of the disease

Elucidating shared biomarkers in gastroesophageal reflux disease and idiopathic pulmonary fibrosis: insights into novel therapeutic targets and the role of angelicae sinensis radix

Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

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