Immunohistologic separation of B‐cell‐positive granulomas from B‐cell‐negative granulomas in paraffin‐embedded tissues with special reference to tumor‐related sarcoid reactions

Brincker, H; Pedersen, Niels Tinggaard

doi:10.1111/j.1699-0463.1991.tb05151.x

Cited by 43 publications

(30 citation statements)

References 16 publications

(13 reference statements)

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“…Figure 3 illustrates clearly the difference between sarcoidosis and GLUS. It has been also observed that the granulomas of GLUS contain natural killer (NK) cells along with the B lymphocytes, whereas NK cells do not appear in the granulomas of sarcoidosis [5]. In summary, although granulomatous lesions due to various etiologies may have similar appearances, both histomorphological and immunohistological differences can be demonstrated, particularly between the granulomas of sarcoidosis and GLUS, supporting the clinical evidence that the GLUS syndrome is distinguishable from sarcoidosis.…”

Section: Discussionmentioning

confidence: 64%

Simultaneous pulmonary and intrathoracic lymph nodal granulomatosis of unknown significance (GLUS)

Katsenos

Κostikas

Lachanis

et al. 2004

Monaldi Arch Chest Dis

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A 30 years old male was referred to the authors' department with complaints of a fever (39,5ºC), non-productive cough, myalgias and fatigue for 10 days before his admission to the hospital. Upon admission, a chest radiograph was performed showing bilateral hilar lymphadenopathy accompanied by fluffy nodular and micronodular opacities predominating in the middle lung fields (figure 1). The patient received one course of antibiotics for common bacterial pathogens, before he sought our medical assistance, with no remission of the above-mentioned symptoms. He was an active smoker (10 pack/years). He worked as an employee in an office in a private company. He had been in good health previously.A thorough physical examination and laboratory evaluation at the time of the admission was normal. Briefly, there were no abnormal findings from the examination of the respiratory system, and there were no signs of involvement of peripheral lymph nodes, hepatic disease or skin lesions. Complete blood count and standard serum biochemistry tests were normal. Serum angiotensin converting enzyme (SACE) was within normal limits (55 U/L). Serum and urine calcium levels were normal. Laboratory tests for collagen-vascular diseases (i.e. C3 and C4 complement components, antinuclear antibodies, c and p ANCA), as well as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were normal. Serologic tests for EbsteinBarr virus (EBV), cytomegalovirus (CMV) and Toxoplasma and Brucella were negative. Additionally, serologic tests for hepatitis A, B and C, as well as for human immunodeficiency virus were negative. Arterial blood gases were normal. Electrocardiogram and echocardiogram were normal, excluding any heart involvement. An ultrasonographic exKeywords: Fever, bilateral hilar lymphadenopathy, nodular opacities, GLUS.

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Section: Discussionmentioning

confidence: 64%

Simultaneous pulmonary and intrathoracic lymph nodal granulomatosis of unknown significance (GLUS)

Katsenos

Κostikas

Lachanis

et al. 2004

Monaldi Arch Chest Dis

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“…(iii) Well-demarcated large EPGs within GC showing suppurations at the center (n = 5) : On the basis of the histological and immunohistochemical features, suppurative EPGs were classified into two subtypes : B-cell -and Bcell + granulomas. [8][9][10][11] The former type of suppurative EPG was composed of histiocytes with or without epithelioid cell features and scattered T-lymphocytes. 7,[10][11][12] The former type of suppurative EPG was located in the GC and IF area.…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Cell Granulomatous Response of Waldeyer's Ring among Japanese : A Clinicopathological and Immunohistochemical Study of 16 Cases

Kaneko

Kojima

Nakazato

et al. 2012

J Clin Exp Hematopathol

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The tonsils are uncommonly affected by granulomatous inflammation. This study attempted to clarify the clinicopathological and immunohistochemical findings and presence or absence of Epstein-Barr virus (EBV) in tonsilar granulomatous inflammation. A total of 537 consecutive specimens from tonsillectomies performed at Dokkyo University School of Medicine between 1999 and March 2012 were reexamined. Using formalin-fixed, paraffin-embedded sections, histological, immunohistochemical, and in situ hybridization (ISH) studies were performed. Epithelioid granulomas (EPGs) were identified in the tonsils in 16 (3.0%) cases. There were 8 males and 8 females, aged 4 to 57 years (mean, 23). In 11 patients, EPGs were located in the germinal center (GC), whereas they were located in the interfollicular area as well as GC in the remaining 5 cases. Three types of EPG have been delineated : (i) poorly demarcated small epithelioid cell granulomas (n = 6) ; (ii) well-demarcated noncaseating sarcoid-like granulomas (n = 5) ; and (iii) EPGs within GC showing suppurations at the center (n = 5). An ISH study demonstrated EBV-encoded small RNA (EBER) + cells in 4 lesions. The present study demonstrated that the majority of EPGs were located in the GC and tonsilar EPGs showed histological variation. 〔J Clin Exp Hematopathol 52(3) : 179-184, 2012〕

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“…It is thought that sarcoid-like granulomas seen in the lymph node represent a local T cell-mediated immune reaction against possible antigens or other factors released from the tumor tissue (23). Sarcoidosis granulomas also contain B cells as a difference at the histopathological level (24).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic value of transbronchial needle aspiration cytology in sarcoidosis

Özbudak

Özbilim²,

Özbudak³

et al. 2011

TJPATH

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Immunohistologic separation of B‐cell‐positive granulomas from B‐cell‐negative granulomas in paraffin‐embedded tissues with special reference to tumor‐related sarcoid reactions

Cited by 43 publications

References 16 publications

Simultaneous pulmonary and intrathoracic lymph nodal granulomatosis of unknown significance (GLUS)

Simultaneous pulmonary and intrathoracic lymph nodal granulomatosis of unknown significance (GLUS)

Epithelioid Cell Granulomatous Response of Waldeyer's Ring among Japanese : A Clinicopathological and Immunohistochemical Study of 16 Cases

Diagnostic value of transbronchial needle aspiration cytology in sarcoidosis

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