Diagnostic value of transbronchial needle aspiration cytology in sarcoidosis

Özbudak, İrem Hicran; Özbilim, Gülay; Özbudak, Ömer; Kovan, Tezay Sandikli

doi:10.5146/tjpath.2011.01064

Cited by 4 publications

(2 citation statements)

References 21 publications

(19 reference statements)

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“…Two studies [25,26] did not find any significant statistical difference. Six studies analyzed lymph node station as the predictor in patients with suspected sarcoidosis [27,28,29,30,31,32], but each one reported different results and the only investigation reporting statistical analysis showed no difference among the stations sampled [30]. One study was performed in patients with suspected tuberculosis and reported the highest accuracy for station 7 [33].…”

Section: Resultsmentioning

confidence: 99%

Transbronchial Needle Aspiration: A Systematic Review on Predictors of a Successful Aspirate

et al. 2013

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Background: Transbronchial needle aspiration (TBNA) is a safe and useful sampling technique for the diagnosis of mediastinal adenopathies/masses, but its accuracy seems to be influenced by selected clinical and procedural aspects. Objectives: We performed a systematic review to identify the main predictors of a successful transbronchial aspirate according to different clinical settings. Methods: We searched Medline and Embase for all studies evaluating predictors of TBNA diagnostic yield, published up to February 2012. Two authors reviewed all titles/abstracts and retrieved the full text of articles that are potentially relevant to identify studies according to predefined selection criteria. The methodological quality of studies was assessed through the revised Quality Assessment of Diagnostic Accuracy Studies tool. Evidence synthesis was graded according to overall number of studies, patients involved and methodological features. Results: Fifty-three studies, involving more than 8,000 patients and evaluating 23 potential predictive factors, were included. Major predictors in an unselected population, as well as in patients with suspected/known lung cancer, included lymph node size (short axis length ≥2 cm), presence of abnormal endoscopic findings, subcarinal and right paratracheal location, and the use of histological needle by an experienced bronchoscopist. Stage I and sampling of more than one lymph node stations were the only predictors of a successful TBNA result in patients with suspected sarcoidosis. Conclusions: The diagnostic yield of TBNA depends on selected clinical and procedural features. Knowledge of factors that predict a positive TBNA result may help optimize the diagnostic success of the procedure in different clinical settings.

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Section: Resultsmentioning

confidence: 99%

Transbronchial Needle Aspiration: A Systematic Review on Predictors of a Successful Aspirate

et al. 2013

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“…TBB's diagnostic effectiveness has been observed to range between 40 and 90 percent in prior research and 68.7% in another investigation. The presence of non-caseating granulomas can be caused by a variety of etiological factors, and accurate clinical correlation can help determine the best treatment strategy (1). TBB was the most used method in the study of Kıter et al, and Sarcoidosis Working Group of Turkish Thoracic Society, which showed a 48.8% success rate (2).…”

Section: Introductionmentioning

confidence: 99%

Petals of rose: Application of rapid on-site evaluation in bronchoscopy

Bhowmik¹,

Thanka²,

Manikandan³

et al. 2022

Biomedicine

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In present day scenario, procedures that are minimally invasive like FNAs and Core needle biopsies are on the rise. Rapid on-site evaluation (ROSE) is a laboratory service that assesses the cytomorphologic features from FNA smears or biopsy contact imprints in the biopsy room and can provide on the spot input and suggestions for the clinician through immediate cytological examination of the biopsy sample. ROSE also allows for a preliminary diagnosis, allowing for the requirement of additional material for ancillary studies. We are presenting two cases which highlights the merits of ROSE in cytological diagnosis. In the first case, a thirty four year old male patient came with complaints of productive cough, breathlessness and fever. Bronchoscopic needle aspiration and biopsy was done with Rapid Onsite Evaluation. ROSE revealed two non-caseating epithelioid granulomas on the 4th pass. Bronchoscopic lymph node biopsy was non- contributory. With other clinical and biochemical parameters, diagnosis of Sarcoidosis was made. This case study underscores the significance of ROSE in arriving at the diagnosis. In the other case, a fifty seven year old male patient came to hospital with productive cough and breathlessness (MMRC grade II). CT chest revealed features suggestive of bronchogenic carcinoma. ROSE was performed along with bronchial brush cytology in which presence of atypical cells with increased nuclear cytoplasmic ratio, nuclear hyperchromatism and nuclear molding was noted. On histopathological examination, it was diagnosed as a case of non-small cell carcinoma of lung – poorly differentiated type. This case proves the advantage of ROSE in avoiding repeated invasive procedures for the patient.

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