Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis

Kitaya, Kotaro; Yasuo, Tadahiro

doi:10.1111/j.1600-0897.2011.01051.x

Cited by 124 publications

(142 citation statements)

References 20 publications

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“…anti-thrombin III) and vascular endothelial growth factors. In the human non-pregnant uterus, syndecan-1 is localized to the cervix and endometrium, but not to the myometrium (18)(19)(20)(21)(22). In the human endometrium, the expression level of syndecan-1 in endometrial epithelial cells is higher in the secretory phase than in the proliferative phase, while that in endometrial stromal fibroblasts is constant throughout the menstrual cycle.…”

Section: Syndecan-1 As a Diagnostic Biomarker For Plasmacyte Infiltramentioning

confidence: 91%

“…In the human endometrium, the expression level of syndecan-1 in endometrial epithelial cells is higher in the secretory phase than in the proliferative phase, while that in endometrial stromal fibroblasts is constant throughout the menstrual cycle. The localization patterns of syndecan-1 in the human endometrium are inconsistent between studies; some authors suggest that it is confined mainly to the apical and basolateral surface in glandular epithelial cells only during the secretory phase, while other authors claim that it has a wide distribution including surface/glandular epithelial cells and stromal fibroblasts (18,(20)(21)(22). Such discrepancies appear to result from the differences in the antibodies used (i.e., mouse monoclonal antibody versus goat polyclonal antibody) and tissue preparation methods (i.e., frozen tissue versus fixed tissue).…”

Section: Syndecan-1 As a Diagnostic Biomarker For Plasmacyte Infiltramentioning

confidence: 99%

See 1 more Smart Citation

Diverse functions of uterine proteoglycans in human reproduction (Review)

Kitaya¹,

Tada²,

Hayashi³

et al. 2012

Mol Med Report

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Abstract. Proteoglycans (PGs) are a group of heavily glycosylated proteins that are present throughout the mammalian body and are involved in a wide variety of biological phenomena, including structural maintenance, tissue remodeling, molecular presentation, cell adhesion and signal transmission. Previous studies have revealed an increasing number of roles for PGs in human reproduction. Several PGs are currently utilized or regarded as biomarkers for the diagnosis of certain pathological uterine conditions associated with infertility and obstetrical complications. The aim of this review was to discuss the involvement of PGs in the human uterus in reproductive biology and pathophysiology. Contents1. Introduction 2. PGs in human endometrium 3. Close association between miscarriage and deficiency in thrombomodulin and syndecan-4 4. Syndecan-1 as a diagnostic biomarker for plasmacyte infiltrates in chronic endometritis 5. DSPGs mediate ectopic growth and development of endometriosis 6. PGs in human myometrium and cervix 7. Contribution of fibromodulin, versican and decorin to structural maintenance and growth of uterine fibroids 8. Low myometrial syndecan-3 expression in dystocia 9. PGs in human placenta 10. Amniotic fluid perlecan and agrin as potential biomarkers for premature rupture of fetal membranes 11. Preventive role of syndecan-1 against pre-eclampsia 12. Upregulation of perlecan in the villi of gestational diabetes mellitus 13. Elevated amniotic fluid lumican concentration in fetus with Turner syndrome 14. Conclusions IntroductionProteoglycans (PGs) are a group of macromolecules which consist of one core protein and one or more covalently attached sulfated glycosaminoglycan (GAG) side chain(s). The PG core proteins are encoded by distinct genes and contain multiple functional domains that bind to and modulate a wide range of molecules, including chemokines, cytokines, growth factors, extracellular matrix (ECM) proteins, coagulation factors and lipid-metabolizing enzymes. The localization of PGs is attributed to the molecular and structural characteristics of their core proteins. GAGs consist of diversely epimerized/sulfated unbranched polysaccharide chains composed of 1,4-linked repeated disaccharide units. According to the combination of disaccharides, the sulfated GAG side chains are classified as chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS) and keratan sulfate (KS). The sulfation status of the GAG side chains in PGs varies with tissue type, location and age, which provides PGs with organ-dependent properties in molecular weight, structure and function (1).PGs are classified into two distinct types by their location in tissues: i) cell surface PGs and ii) ECM PGs (Table I). The cell surface PGs include the syndecan and glypican families. Syndecans are a group of transmembrane HSPGs that interact with and regulate various soluble molecules. Glypicans are glycosylphosphatidylinositol-anchored HSPGs on the outer surface of the plasma membrane that regulate multiple intracellular sig...

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Section: Syndecan-1 As a Diagnostic Biomarker For Plasmacyte Infiltramentioning

confidence: 91%

Section: Syndecan-1 As a Diagnostic Biomarker For Plasmacyte Infiltramentioning

confidence: 99%

Diverse functions of uterine proteoglycans in human reproduction (Review)

Kitaya¹,

Tada²,

Hayashi³

et al. 2012

Mol Med Report

Self Cite

View full text Add to dashboard Cite

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“…kürettiert werden. Meist finden sich nur diskrete histomorphologische Verände-rungen, die durch ein geringes lymphoplasmazelluläres Infiltrat charakterisiert sind, wobei die immunhistochemische Darstellung der Plasmazellen mithilfe von CD138 hilfreich ist [10]. Eine chronische Endometritis findet sich bei etwa 30 % der Patientinnen mit wiederholten Implantationsproblemen des Embryos nach In-vitro-Fertilisation, ebenso bei etwa 30 % der Patientinnen mit unerklärbarer Infertilität und 12 % der Patientinnen mit unerklärbarem wiederholtem Abort.…”

Section: Chronische Endometritis Als Ursache Für Infertilitätunclassified

“…In einer retrospektiven Untersuchung an Archivmaterial wurde eine chronische Endometritis in 11 % der Endometriumproben mit benignen Veränderungen des Endometriums gefunden. Allerdings fehlten bei dieser Untersuchung Nachweise mögli-cher infektiöser Ursachen [10]. In einer Untersuchung an Frauen mit 2 oder mehr Aborten fanden sich plasmazelluläre Infiltrate in 56 % der Fälle unter Einsatz der CD138-Immunhistochemie, wobei die Detektionsrate mithilfe der HE-Histologie mit 13 % deutlich niedriger war.…”

Section: Chronische Endometritis Als Ursache Für Infertilitätunclassified

Endometritis

Lax¹

2016

Pathologe

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“…В современных условиях ХЭ имеет ряд особенностей: смену этиологических факторов с увеличением роли ви-русной инфекции и УПМ, рост устойчивости УПМ к фар-макотерапии, изменение клинической симптоматики в сторону увеличения числа стертых форм и случаев ати-пичного течения, более длительные сроки терапии и ее высокую стоимость [20].…”

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Chronic endometritis: State-of-the-art, main aspects of pathogenesis, impact on reproductive function

Yakovchuk¹,

Sulima²,

Рыбалка³

et al. 2016

Ross. vestn. akush.-ginekol.

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Среди супружеских пар детородного возраста частота бесплодия в разных регионах России колеблется от 8 до 19%. Восстановление репродуктивной функции в услови-ях сложной демографической ситуации в стране -задача, выходящая за рамки только медицинской науки. В связи с этим к вспомогательным репродуктивным технологиям (ВРТ) проявляют повышенный интерес не только в Рос-сии, но и за рубежом. Во многих странах эффективность результатов экстракорпорального оплодотворения (ЭКО) и переноса эмбрионов (ПЭ) определяется двумя фактора-ми -функциональной полноценностью эмбриона на ста-дии бластоцисты и отсутствием внутриматочной патоло-гии. Одной из главных причин неполноценной или не-удачной имплантации являются нарушенная функция и e-mail: miss.yakovchuk@mail.ru Представлен анализ опубликованных работ последних лет, касающийся вопросов этиологии и патогенеза хронического эндометрита. Хронический эндометрит -клинико-морфологический синдром, при котором в результате персистиру-ющего повреждения эндометрия инфекционным фактором возникают множественные вторичные морфофункциональ-ные изменения, нарушающие циклическую биотрансформацию и рецептивность слизистой оболочки тела матки. Среди женщин с верифицированным хроническим эндометритом у 60% диагностируется бесплодие. Особенностями хрониче-ского эндометрита в настоящее время являются увеличение значимости условно-патогенной микрофлоры, рост устой-чивости условно-патогенных микроорганизмов к фармакотерапии, увеличение числа стертых форм и атипичного тече-ния. При реализации хронического воспалительного процесса в эндометрии на клеточном уровне происходят следующие нарушения: расстройства метаболизма, нарушение цепи иммунокомпетентной системы и развитие аутоиммунных про-цессов, нарушение эспрессии рецепторов стероидных гормонов, формирование провоспалительного Th-1-типа имунного ответа вместо необходимого для успешного развития беременности Th-2-типа такого ответа, ухудшение микроциркуля-ции, нарастание гипоксии, дисбаланса про-и антиоксидантной систем.Авторы информируют об отсутствии конфликта интересов. The paper analyzes published recent papers on the etiology and pathogenesis of chronic endometritis. The latter is a clinical and morphological syndrome, in which persistent endometrial injury caused by infection results in multiple secondary morphofunctional changes impairing cyclic biotransformation and mucosal receptivity of the corpus uteri. Infertility was diagnosed in 60% of women with verified chronic endometritis. The specific features of chronic endometritis are now the increased significance of the opportunistic microflora, the higher resistance of opportunistic microorganisms to pharmacotherapy, a larger number of subtle forms, and an atypical course. When a chronic inflammatory process occurs in the endometrium, there are the following disorders at the cellular level: metabolic disturbances; immunocompetent system chain breakdown and development of autoimmune processes; impaired steroid hormone receptors expression; formation of a proinflammatory Th1-immune response in...

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Immunohistochemistrical and Clinicopathological Characterization of Chronic Endometritis

Abstract: Chronic endometritis is a common gynecological pathological condition and more often asymptomatic than ever expected. There was no menstrual cycle-dependent fluctuation in its occurrence.

Cited by 124 publications

References 20 publications

Diverse functions of uterine proteoglycans in human reproduction (Review)

Diverse functions of uterine proteoglycans in human reproduction (Review)

Endometritis

Chronic endometritis: State-of-the-art, main aspects of pathogenesis, impact on reproductive function

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