1995
DOI: 10.1016/0003-9969(95)00024-j
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Immunohistochemical study on the immunocompetent cells of the pulp in human non-carious and carious teeth

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Cited by 115 publications
(141 citation statements)
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“…Among immune cells, macrophages are considered to play critical roles in tissue homeostasis and mediate innate and subsequent acquired immune responses. Several studies have clarified that macrophages predominate inflamed pulp tissues (Izumi et al 1995;Bruno et al 2010) and that their number increases with the progression of caries in human pulp tissues (Hahn et al 2000;Hahn and Liewehr 2007). Furthermore, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β)-the major proinflammatory cytokines produced by macrophages-have been shown to be discriminatively elevated in the inflamed pulp as compared with the healthy pulp (McLachlan et al 2004;Veerayutthwilai et al 2007;Cooper et al 2010), suggesting that macrophages play a key role in the progression of pulpal inflammation and contribute to the pathologic transition from reversible to irreversible pulpitis (IP).…”
Section: Introductionmentioning
confidence: 99%
“…Among immune cells, macrophages are considered to play critical roles in tissue homeostasis and mediate innate and subsequent acquired immune responses. Several studies have clarified that macrophages predominate inflamed pulp tissues (Izumi et al 1995;Bruno et al 2010) and that their number increases with the progression of caries in human pulp tissues (Hahn et al 2000;Hahn and Liewehr 2007). Furthermore, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β)-the major proinflammatory cytokines produced by macrophages-have been shown to be discriminatively elevated in the inflamed pulp as compared with the healthy pulp (McLachlan et al 2004;Veerayutthwilai et al 2007;Cooper et al 2010), suggesting that macrophages play a key role in the progression of pulpal inflammation and contribute to the pathologic transition from reversible to irreversible pulpitis (IP).…”
Section: Introductionmentioning
confidence: 99%
“…Pulp inflammation is a dynamic and complex process involving a number of neural, vascular and immunological reactions [5,6], often varied in different tissue regions [7]. In the case of severe chronic inflammation the tissue becomes necrotic, whereas chronic irritation of smaller intensity can lead to pulp degeneration and atrophy [8].…”
Section: Introductionmentioning
confidence: 99%
“…A chronic pulpal inflammation under caries is likely elicited by bacterial antigens that diffuse into the pulp through dentinal tubules (2,3,14). Immunohistological studies of dental pulps under shallow caries have revealed a lesion that is restricted almost exclusively to T cells, with CD8 ϩ T cells predominating (9, 14).…”
mentioning
confidence: 99%