Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor

Itoh, Shigeto; Matsui, Kazuhiro; Furuta, Isao; Takano, Yasuo

doi:10.1016/s1368-8375(03)00105-2

Cited by 81 publications

(92 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current study demonstrated the expression of COX-2 in the odontogenic epithelium of dentigerous cyst and ameloblastoma. COX-2 is upregulated in a wide variety of human tumors including oral cancer (12,(23)(24)(25). The precise contribution of COX-2 to neoplastic growth has not been elucidated (26).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, epidemiological studies indicate that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of malignancies, particularly in the digestive tract (28). Studies have indicated an association of COX-2 expression with the initiation of tumorigenesis (29), malignant transformation (19), local invasion (30), lymph node metastasis (23), and recurrence (28,31). The expression of COX-2 in precancerous lesions has been reported to be higher than that in malignancies in various human organs, including bronchial (32), colonic (33), esophageal (34), as well as head and neck tumors (25,35,36).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Alsaegh

Matsumoto

Taniguchi

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

Abstract. Investigation of cyclooxygenase (COX)-2 in dentigerous cyst and ameloblastoma may help to improve understanding of the nature and behavior of odontogenic cysts and tumors, and in addition may eventually represent a definitive target for a pharmacological approach in the management of these lesions. The aim of this study was to evaluate COX-2 expression and its correlation with the proliferation of odontogenic epithelium in these lesions. Dentigerous cysts (n=16) and ameloblastomas (n=17) were evaluated. Detection of Ki-67 and COX-2 protein expression was conducted by immunohistochemistry. Data were statistically analyzed using Mann-Whitney U test and Spearman's rank correlation coefficient. No significant differences were found in the expression of Ki-67 and COX-2 between dentigerous cysts and ameloblastomas (P>0.05). A significant positive correlation (P= 0.018) and highly significant positive correlation (P=0.004) were found between Ki-67 and COX-2 expression in the odontogenic epithelium of dentigerous cyst and ameloblastoma, respectively. COX-2 was expressed in the odontogenic epithelium of dentigerous cyst and ameloblastoma. It may contribute to local extension of these lesions by increasing the proliferation of their odontogenic epithelial cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Alsaegh

Matsumoto

Taniguchi

et al. 2016

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…Overexpression of COX-2 has been previously described in OPLs and OSCCs and has been suggested to precede alterations in expression of other markers of tumor progression related to apoptosis and angiogenesis. [11][12][13][28][29][30] Another immunohistochemical study on the expression of COX-1 and COX-2 expression showed that though labeling indices (LIs) for COX-1 and COX-2 were higher in oral dysplasia than OSCCs, LIs of COX-2 but not COX-1 correlated with the histological grade of dysplasia. 13 In addition, no significant relationship was observed between COX-2 expression and LIs of Ki-67, p53, apoptotic indices and microvessel density for dysplasia and SCCs.…”

Section: Discussionmentioning

confidence: 99%

Expression of NF‐κB parallels COX‐2 expression in oral precancer and cancer: Association with smokeless tobacco

Sawhney

Rohatgi

Kaur

et al. 2007

Intl Journal of Cancer

116

View full text Add to dashboard Cite

Nuclear Factor‐κB (NF‐κB) activation and COX‐2 overexpression have been reported in head and neck cancer, but the relationship between these proteins remains to be investigated. To determine the relationship between NF‐κB and COX‐2 in Smokeless Tobacco (ST) associated oral tumorigenesis, we performed immunohistochemistry in serial sections from 107 OSCCs, 78 oral precancerous lesions (OPLs) (58 hyperplasias, 20 dysplasias) and 15 histologically normal oral tissues and correlated with clinicopathological data. Significant increase in NF‐κB and COX‐2 immunopositivity was observed from normal oral mucosa to OPLs to OSCCs (p = 0.009 and p = 0.002 respectively). Upregulation of NF‐κB and COX‐2 was observed as early as in hyperplasia [p = 0.006; OR = 6.1 and p = 0.003; OR = 7.6, respectively]. Expression of both proteins was found to be significantly associated in OPLs (p = 0.000; OR = 12.6) and OSCCs (p = 0.001; OR = 4.0). Intriguingly, khaini consumption correlated with NF‐κB immunopositivity in OPLs (p = 0.05, OR = 3.8) and OSCCs (p = 0.01, OR = 3.4) and with COX‐2 expression in OPLs (p = 0.03; OR = 4.3). In vitro experimental system of ST associated oral carcinogenesis was used to demonstrate ST (khaini) and NNK mediated activation of NF‐κB and COX‐2, supporting the clinical data. In conclusion, this study demonstrates correlation between over expression of NF‐κB and COX‐2 in early precancerous stages of development of oral cancer and sustained elevation down the tumorigenic pathway, underscoring their potential as targets for early intervention. In vitro studies demonstrated that NNK may be one of the carcinogenic components of ST (khaini) inducing activation of NF‐κB and COX‐2 in oral precancer and cancer cells, suggesting plausible role in ST‐induced oral carcinogenesis. © 2007 Wiley‐Liss, Inc.

show abstract

“…Recently, a strong correlation was found in OSCC between high COX-2 expression and higher lymph node involvement, higher recurrence rates, and shorter disease-free survival. 45 Marked COX-2 expression was found in the cytoplasm of cells of the tumor invasive front and also in the cells of the surrounding stroma and vessels, indicating a putative role in tumor invasion and development of metastases. 16,46 Another study demonstrated that COX-2 overexpression in OSCC was associated with higher radioresistance; tumor cells treated in vitro with a COX-2 inhibitor showed better response to radiotherapy.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 98%

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Massano

Regateiro

Januário

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

544

455

View full text Add to dashboard Cite

Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor

Cited by 81 publications

References 16 publications

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Odontogenic epithelial proliferation is correlated with COX-2 expression in dentigerous cyst and ameloblastoma

Expression of NF‐κB parallels COX‐2 expression in oral precancer and cancer: Association with smokeless tobacco

Oral squamous cell carcinoma: Review of prognostic and predictive factors

Contact Info

Product

Resources

About