Immunohistochemical study of immunoglobulin light chains and inflammatory cells in a patient with localized primary cutaneous nodular amyloidosis

Cai, Y.‐X.; Li, S.‐J.; Zhou, Ying; Li, W.; Fan, Yi‐Ming

doi:10.1111/jdv.12849

Cited by 6 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary localized cutaneous amyloidosis consists of three main variants: macular amyloidosis, lichen amyloidosis and primary localized cutaneous nodular amyloidosis (PLCNA). In lichen and macular amyloidosis, amyloid is made by keratin while PLCNA is characterized by an abnormal cutaneous deposition of immunoglobulins, predominantly amyloid light-chain amyloidosis (AL), secondary to a localized proliferation of plasma cells [ 1 , 2 , 3 , 4 , 5 ]. Despite monoclonal plasma cell proliferation, no systemic hematological involvement is usually found at PLCNA diagnosis [ 2 ], although a 7% risk of myeloma development has been reported [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition

et al. 2021

View full text Add to dashboard Cite

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition due to the plasma cell proliferation and skin deposition of immunoglobulin light chains, without systemic amyloidosis or hematological dyscrasias. The association with autoimmune connective tissue diseases has been reported, especially with Sjogren’s syndrome, and in a few cases with systemic sclerosis. Herein, we describe three cases of PLCNA occurring in women with a diagnosis of limited cutaneous systemic sclerosis and review the literature on the topic to highlight a stereotypical presentation. Moreover, we support the usefulness of dermoscopy, characterized by a yellow–orange waxy pattern surrounded by telangiectasias, for a rapid and non-invasive diagnostic assessment. Thus, when asymptomatic nodules occur on lower limbs of women affected with limited systemic sclerosis, and dermoscopy identifies yellow–orange blotches, a diagnosis of PLCNA can be considered and further confirmed by histopathology. Monitoring for systemic amyloidosis development is advisable, although the risk of progression is considered very low.

show abstract

Section: Introductionmentioning

confidence: 99%

Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition

et al. 2021

View full text Add to dashboard Cite

show abstract

“…2,3 Primary nodular localized cutaneous amyloidosis is a local proliferation of monoclonal plasma cells without systemic hematological involvement. [10][11][12][13][14][15][16] Thus, primary nodular localized cutaneous amyloidosis acts like a plasmacytoma outside the bone marrow suggesting a local pathogenesis. 17,18 The monoclonal plasma cells are most likely responsible for the production of localized amyloid.…”

Section: Discussionmentioning

confidence: 99%

Primary localized cutaneous lichen myxedematosus with light chain‐restricted plasma cells: A distinct variant of the localized form of lichen myxedematosus

Liu,

Park,

Karim

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

Lichen myxedematosus (LM) is a chronic cutaneous mucinosis that can present as a localized skin lesion or as a generalized systemic disease termed scleromyxedema. The differential diagnosis is determined by a combination of clinical presentation, serological studies, and histopathological examination. Currently, well‐established and accepted histopathological features to distinguish localized LM from scleromyxedema have not been elucidated. Our recent publication, together with a retrospective literature review, suggests that the presence of groups of light chain‐restricted plasma cells represents a distinct histopathological clue for the diagnosis of localized LM. In this report, we provide two additional cases of localized LM with lambda light chain‐restricted plasma cells, together with clinical and histopathological findings that are similar to our previous publication. These cases support our theory that the light chain‐restricted plasmacytic microenvironment is primarily attributed to the pathogenesis of localized LM. Therefore, we consider these cases to constitute a clinically and pathologically new variant of localized LM and name it primary localized cutaneous LM with light chain‐restricted plasma cells.

show abstract

Chalazodermie amyloïde multifocale. Le concept d’élastopathie immunoglobulinémique

Hazemann

Gusdorf

Mitcov

et al. 2018

Annales de Dermatologie et de Vénéréologie

View full text Add to dashboard Cite

Immunohistochemical study of immunoglobulin light chains and inflammatory cells in a patient with localized primary cutaneous nodular amyloidosis

Cited by 6 publications

References 9 publications

Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition

Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition

Primary localized cutaneous lichen myxedematosus with light chain‐restricted plasma cells: A distinct variant of the localized form of lichen myxedematosus

Chalazodermie amyloïde multifocale. Le concept d’élastopathie immunoglobulinémique

Contact Info

Product

Resources

About