Chalazodermie amyloïde multifocale. Le concept d’élastopathie immunoglobulinémique

Hazemann, G.; Gusdorf, L.; Mitcov, M.; Lenormand, C.; Lipsker, Dan

doi:10.1016/j.annder.2018.07.021

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Authors reporting a similar case in the French literature proposed the concept of “immunoglobulinemic elastopathy” to encompass plasma cell dyscrasias associated with elastic fiber alterations by clinical morphology or histopathologic findings. 12 They reported the case of a 67-year-old woman with anetodermic lesions that, on biopsy, demonstrated elastolysis and deep dermal and subcutaneous amyloid deposits that were lambda light chain–positive by immunohistochemistry. Systemic workup revealed a monoclonal IgG lambda gammopathy.…”

Section: Discussionmentioning

confidence: 99%

A Second Case of Localized Cutaneous Amyloid Elastosis: Expanding the Discussion of Associations With a Unique Histopathologic Entity

Roberts

Dittmer

Vidal

et al. 2021

The American Journal of Dermatopathology

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Amyloid elastosis is an exceedingly rare form of amyloidosis characterized by amyloid material deposited on dermal elastic fibers. Most reported cases have been associated with systemic amyloid light-chain amyloidosis. A single previously reported case of amyloid elastosis showed evidence that the amyloid material was derived from light-chain proteins and was associated with a monoclonal plasma cell infiltrate but failed to demonstrate systemic involvement. As a result, the case was felt to represent localized cutaneous amyloid elastosis. We present a case of localized cutaneous amyloid elastosis that is not associated with a definitive monotypic plasma cell population or with systemic amyloidosis. We also review the clinical and histopathologic features of reported cases of amyloid elastosis and discuss possible etiologic considerations. Because amyloid elastosis can be either localized to the skin or associated with systemic involvement, additional workup to exclude an underlying plasma cell dyscrasia or hematologic malignancy is warranted.

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Section: Discussionmentioning

confidence: 99%

A Second Case of Localized Cutaneous Amyloid Elastosis: Expanding the Discussion of Associations With a Unique Histopathologic Entity

Roberts

Dittmer

Vidal

et al. 2021

The American Journal of Dermatopathology

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“…There are 10 reported cases in the literature, three with primary localized cutaneous (PLC) AE and seven with AE associated with systemic amyloidosis (SA). [1][2][3][4][5] Patients with PLC AE have an average age of 49.9 years, with 66% presenting a single anetodermic plaque. In contrast, patients with systemic AE have an average age of 56.…”

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confidence: 99%

A new case of amyloid elastosis – dermoscopic findings and literature review

Bettolini,

Alessandro,

Bighetti

et al. 2024

Int J Dermatology

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A new case of amyloid elastosisdermoscopic findings and literature review Dear Editor, Amyloid elastosis (AE) is a rare form of cutaneous amyloidosis. We report a case of AE in a 58-year-old man, along with a review of the existing literature. The patient presented with three lesions, the most recent being a patch on his right arm's posterior side. The other two, with an anetodermic appearance, had emerged 40 years earlier on his back and right arm (Figure 1ac). Dermoscopy of the recent patch revealed purpuric blood spots on a yellow background, while the other two lesions exhibited an erythematous background with interrupted pigmented networks and perifollicular translucent aspects (Figure 1d-f). Histopathological examination confirmed AE, featuring an increase and degenerative alteration of the elastic fibers with notable basophilia and an accumulation of amyloid-compatible amorphous material in the reticular dermis. Orcein staining further verified a collection of dystrophic elastic fibers surrounded by amorphous material that stained positive for Red Congo with apple-green birefringence under polarized microscopy.

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Anetoderma Schweninger-Buzzi: Two Case Reports

Wollina¹,

Mühle²,

Lotti³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Anetodermas are rare disorders of connective tissue with a focal loss of elastic fibres in the upper and mid dermis. Two types are separated, inflammatory and non-inflammatory. CASE REPORTS: We report two cases of acquired anetoderma Schweniger-Buzzi type. This non-inflammatory subtype is characterised by skin-coloured or whitish atrophic sac-like protrusions of trunk skin in adult males. Chronic infections and autoimmune disorders have been excluded. The diagnosis had been confirmed by characteristic histopathology. CONCLUSIONS: Anetodermas are symptomless disorders. They can be easily overlooked. The knowledge of such conditions is of importance to identify patients with a risk of thromboembolic events and underlying infections or autoimmune connective tissue diseases.

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Chalazodermie amyloïde multifocale. Le concept d’élastopathie immunoglobulinémique

Cited by 3 publications

References 37 publications

A Second Case of Localized Cutaneous Amyloid Elastosis: Expanding the Discussion of Associations With a Unique Histopathologic Entity

A Second Case of Localized Cutaneous Amyloid Elastosis: Expanding the Discussion of Associations With a Unique Histopathologic Entity

A new case of amyloid elastosis – dermoscopic findings and literature review

Anetoderma Schweninger-Buzzi: Two Case Reports

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