Immunohistochemical study of carbonic anhydrase in mixed tumours and adenomas of sweat and sebaceous glands

Noda, Yoko; Oosumi, Hiroyuki; Morishima, Takafumi; Tsujimura, Takahiro; Mori, Masahiko

doi:10.1111/j.1600-0560.1987.tb00501.x

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…9,10 There is evidence that several isoenzymes with carbonic anhydrase activity exist in the sweat gland coil and duct membrane, but their exact role is not clear. 11,12 A study of exercised horses suggested that carbonic anhydrase might play a role in counteracting the alkalosis that developed after exercise by delivering HCO 3 Ϫ for generating alkaline sweat. 13 Zonisamide was the first drug reported to cause reversible oligohydrosis in a significant manner.…”

Section: Discussionmentioning

confidence: 99%

Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect

et al. 2003

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A 6-year-old boy with partial complex seizures developed recurrent episodes of hyperthermia 2 months after topiramate was introduced into his antiepilepsy drug regimen. Further investigation revealed that the febrile episodes were related to environmental temperature and physical activity. A pilocarpine iontophoresis sweat test showed that the amount of sweat produced by the child was 5% that of age-matched controls. Topiramate discontinuation resulted in the disappearance of febrile episodes and normalization of sweat quantity in repeat sweat testing. Based on this observation and the previous data on zonisamide and isolated case reports on topiramate-related hyperthermia and the effect on sweat production, topiramate was suspected of causing oligohydrosis. A pilot study was carried out involving 13 additional children and young adults (age range 1-37 years) receiving topiramate. All patients were directly questioned regarding symptoms of decreased sweating and heat intolerance, went through a pilocarpine iontophoresis sweat test, and were compared with 14 age-matched controls who went through the sweat test for unrelated reasons. Nine of the patients were found to have reduced sweat quantity on the pilocarpine iontophoresis sweat test (including index case) (mean 0.089 g/30 minutes, SD 0.082; age-matched control: mean 0.21 g/30 minutes, SD 0.06). Eight of them were children (below 16 years). However, only three patients revealed symptoms related to heat intolerance. Topiramate is most likely responsible for decreased sweat production as detected by a pilocarpine iontophoresis sweat test. The effect seems to be more significant in children than in adults. There is a discrepancy between test results and clinical symptoms. Interestingly, oligohydrosis was found to be a relatively common side effect of zonisamide. Both zonisamide and topiramate share a carbonic anhydrase inhibitor activity. The significance of oligohydrosis in hot climates should not be underestimated. Its extent, the role of sweat test prediction, and clinical significance during topiramate treatment should be further estimated.

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Section: Discussionmentioning

confidence: 99%

Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect

et al. 2003

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“…Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer, including cutaneous cancers 127–130 , as well as in chronic skin defects such as inflammation and burns 131–134 . Carbonic anhydrase II elevation has been reported in mycosis fungoides 135 , in adenomas, in glandular tumours (sweat, sebaceous, and major salivary glands), and in various tumours of the skin 136–139 . Cytochrome P450 enzyme systems are involved in drug biotransformation, and as such, are especially noteworthy for their involvement in numerous deleterious drug–drug interactions 140 , 141 .…”

Section: Resultsmentioning

confidence: 99%

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Boateng,

Roy,

Torrey

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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Twenty-five azole compounds ( P1 – P25 ) were synthesised using regioselective base-metal catalysed and microwave-assisted approaches, fully characterised by high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and infrared spectra (IR) analyses, and evaluated for anticancer, anti-tyrosinase, and anti-oxidant activities in silico and in vitro . P25 exhibited potent anticancer activity against cells of four skin cancer (SC) lines, with selectivity for melanoma (A375, SK-Mel-28) or non-melanoma (A431, SCC-12) SC cells over non-cancerous HaCaT-keratinocytes. Clonogenic, scratch-wound, and immunoblotting assay data were consistent with anti-proliferative results, expression profiling therewith implicating intrinsic and extrinsic apoptosis activation. In a mushroom tyrosinase inhibition assay, P14 was most potent among the compounds (half-maximal inhibitory concentration where 50% of cells are dead, IC 50 15.9 μM), with activity greater than arbutin and kojic acid. Also, P6 exhibited noteworthy free radical-scavenging activity. Furthermore, in silico docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) simulations predicted prominent-phenotypic actives to engage diverse cancer/hyperpigmentation-related targets with relatively high affinities. Altogether, promising early-stage hits were identified – some with multiple activities – warranting further hit-to-lead optimisation chemistry with further biological evaluations, towards identifying new skin-cancer and skin-pigmentation renormalising agents.

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“…Since the demonstration of CEA in normal sweat glands, and benign, and malignant sweat gland tumors (12-14), many antigens have been demonstrated in normal sweat gland tumors. These antigens inelude S-100 protein (15), beta-2-mieroglobuhn (16), actin (17), casein (18), pregnancy specific beta-1-glycoprotein (17), gross cystic disease fluid protein-15 (CCDEP-15) (19), carbonic anhydrase (20), Leu Ml (21), alphalactalbumin (22), salivary amylase (22), and keratin (23)(24)(25). We used anti-CEA serum absorbed by non-specific cross-reacting antigen, anti-secretory component serum, anti-lactoferrin serum, anti-colostrum whey serum and anti-human milk protein serum.…”

Section: Discussionmentioning

confidence: 99%

A case of tubular apocrine adenoma with syringocystadenoma papilliferum

1989

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Immunohistochemical study of carbonic anhydrase in mixed tumours and adenomas of sweat and sebaceous glands

Cited by 6 publications

References 13 publications

Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect

Oligohydrosis and Hyperthermia: Pilot Study of a Novel Topiramate Adverse Effect

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

A case of tubular apocrine adenoma with syringocystadenoma papilliferum

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