Immunohistochemical Study of a Granular Cell Tumor on the Tongue of a Dog

Rallis, Timoleon; Tontis, D.; Soubasis, Nektarios; Patsiaura, K.K.; Papazoglou, Lyssimachos; Adαmama-Moraitou, K. K.

doi:10.1111/j.1939-165x.2001.tb00260.x

Cited by 20 publications

(30 citation statements)

References 16 publications

(36 reference statements)

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“…5 In a large retrospective study that reviewed 1,196 lingual biopsy specimens from dogs, 26 types of neoplasms were diagnosed. 5,8,9,10 The tongue is the most common site reported for the GCT, with other locations limited to the oral cavity. 6 In this study, GCT accounted for 41 cases of the 232 benign tumors.…”

Section: Figurementioning

confidence: 99%

“…Malignant melanoma (n=148) represented 23% of all lingual neoplasms (n=646), followed by squamous cell carcinoma (n=113), hemangiosarcoma (n=38), fibrosarcoma (n=35), and mast cell tumor (n=19). 5,9,10,19 The two references to lingual MPNST in the dog were in retrospective studies and neither mentioned immunohistochemical characterization. A diagnosis of PNST was made in 2 cases.…”

Section: Figurementioning

confidence: 99%

“…[1][2][3][4][5] In several canine retrospective studies of lingual tumors, malignant tumors comprised 64% of reported neoplasms with malignant melanoma and squamous cell carcinoma being the most frequent. 5,6 There are few reports of lingual GCT 5,6,9,10 , or malignant peripheral nerve sheath tumor (MPNST) 5,6 in the dog. 5,6 There are few reports of lingual GCT 5,6,9,10 , or malignant peripheral nerve sheath tumor (MPNST) 5,6 in the dog.…”

Section: Introductionmentioning

confidence: 99%

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Lingual Malignant Peripheral Nerve Sheath Tumor in a Chinese Pug Dog

Baratt¹,

Rawlinson²,

Roth-Johnson³

et al. 2015

J Vet Dent

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A 9-year-old spayed/female Chinese Pug dog presented for evaluation of a mass located on the rostral aspect of the tongue. An incisional biopsy was acquired, submitted, and interpreted as a possible granular cell tumor based on hematoxylin and eosin, and periodic acid Schiff histopathologic staining characteristics. The diagnosis was supported by immunohistochemical evaluation that was positive for S-100, vimentin, and neuron-specific enolase. Based on the absence of mitotic figures in the incisional biopsy, a partial glossectomy was performed with gross margins of at least 1-cm. The excisional biopsy revealed significant features of malignancy, with neoplastic cells in close association with peripheral nerves, consistent with malignant peripheral nerve sheath tumor. Tumor-free margins were obtained, and the glossectomy had expected healing with no recurrence apparent 6-months following surgery.

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Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lingual Malignant Peripheral Nerve Sheath Tumor in a Chinese Pug Dog

Baratt¹,

Rawlinson²,

Roth-Johnson³

et al. 2015

J Vet Dent

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“…In animals, GCTs have been reported mostly in the lungs of horses 19,31 and in the oral cavity of dogs, 6,21,32 and they have also been diagnosed in cats, humans, and birds. 11,20 In addition, experimental studies in rats exposed to carcinogens 4 and mice treated with estrogen 9 demonstrated development of GCTs.…”

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confidence: 99%

Granular Cell Tumor in a Lumbar Spinal Nerve of a Dog

et al. 2010

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Abstract.A 2-year-old Great Dane dog with a 2.5-week history of progressive paraparesis was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin-Madison. Neurologic examination revealed nonambulatory paraparesis with reduced to absent withdrawal hind-limb reflexes and lumbar pain. Magnetic resonance imaging and gross pathology confirmed a larger regional lumbar mass and a second smaller extradural mass within the spinal canal. The left lumbar mass was associated with extensive hemorrhage; dissection showed a dark-red, soft, well-circumscribed mass measuring 2 cm 3 1.5 cm 3 0.5 cm within the left fourth lumbar spinal nerve. Histopathological evaluation with immunohistochemistry revealed sheets of round to polygonal cells with diffuse granular cytoplasm demonstrating diastase-resistant periodic acid-Schiff reactivity and positive immunoexpression of S100 and neuron-specific enolase. The smaller extradural mass within the spinal canal exhibited similar morphology. Based on gross, histological, and immunohistochemical evidence, the masses were diagnosed as granular cell tumor.

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“…Outros tumores descritos nessa localização em cães incluem mioblastoma de células granulares, rabdomioma, rabdomiossarcoma, hemangioma, hemangiossarcoma, mastocitoma, fibrosssarcoma, linfoma e melanoma (SCHOOFS, 1997;HARVEY, 1998;LASCELLES et al, 1998;RALLIS et al, 2001 Em cães, quando for possível a realização da ressecção cirúrgica completa, a taxa de sobrevida em um ano pode superar os 50%, porém tais casos não são comuns e a taxa de sobrevida geralmente é inferior a 25% após um ano de pós-operatório (MORRISON, 1998;WITHROW, 2001). Segundo CARPENTER et al (1993), a cirurgia é o tratamento de eleição para estes neoplasmas, uma vez que os cães toleram bem a glossectomia parcial.…”

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