Immunohistochemical Staining of Surfactant Proteins A and B in Skin of Psoriatic Patients Before and After Narrow-Band UVB Phototherapy

Aiad, Hayam A; El-Farargy, Shawky M; Soliman, Mostafa M.; Gaber, Mohamed A; Othman, Shaymaa Abd El-Aziz

doi:10.2165/11630720-000000000-00000

Cited by 4 publications

(6 citation statements)

References 34 publications

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“…Aiad et al. found that SP-A was mainly detected in the basal layer, which was agreed upon by Akman ( 63 , 64 ). SP-D was found to be restricted in the basal layer, rather than diffusely spread, in later research by Hohwy et al.…”

Section: Role Of Collectins In Skin Immune Homeostasissupporting

confidence: 72%

“…In a rather early study by Mo et al, SP-A appeared in the stratum corneum and stratum granulosum, while SP-D was distributed in all epidermal layers and the dermis (37). Aiad et al found that SP-A was mainly detected in the basal layer, which was agreed upon by Akman (63,64). SP-D was found to be restricted in the basal layer, rather than diffusely spread, in later research by Hohwy et al (44).…”

Section: Sp-a and Sp-dmentioning

confidence: 61%

“…TNF-a contributes a lot to the pathogenesis of psoriasis. The variation trend of TNF-a in serum has been found corresponding with those of SP-A and SP-D (44,63). As in psoriasis, immunohistochemistry shows high levels of SP-A and SP-D in the skin lesions of atopic dermatitis, lichen planus, and Behcȩt's disease (64).…”

Section: Sp-a and Sp-dmentioning

confidence: 80%

“…SP-A and SP-D participate also in skin inflammatory diseases, such as psoriasis. SP-A and SP-D have both been found to be diffusely positive in the epidermis of psoriatic lesions by immunohistochemistry ( 44 , 63 ). This phenomenon is not involved with stronger staining intensity but more with increased numbers of stained cells.…”

Section: Role Of Collectins In Skin Immune Homeostasismentioning

confidence: 99%

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A Plausible Role for Collectins in Skin Immune Homeostasis

Xiao

Xia

2021

Front. Immunol.

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The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin. This homeostasis depends on interactions among a variety of cells, cytokines, and the complement system. Collectins belong to the lectin pathway of the complement system, and have various roles in innate immune responses. Mannose-binding lectin (MBL), collectin kidney 1, and liver (CL-K1, CL-L1) activate the lectin pathway, while all have multiple functions, including recognition of pathogens, opsonization of phagocytosis, and modulation of cytokine-mediated inflammatory responses. Certain collectins are localized in the skin, and their expressions change during skin diseases. In this review, we summarize important advances in our understanding of how MBL, surfactant proteins A and D, CL-L1, and CL-K1 function in skin immune homeostasis. Based on the potential roles of collectins in skin diseases, we suggest therapeutic strategies for skin diseases through the targeting of collectins and relevant regulators.

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Section: Role Of Collectins In Skin Immune Homeostasissupporting

confidence: 72%

Section: Sp-a and Sp-dmentioning

confidence: 61%

Section: Sp-a and Sp-dmentioning

confidence: 80%

Section: Role Of Collectins In Skin Immune Homeostasismentioning

confidence: 99%

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A Plausible Role for Collectins in Skin Immune Homeostasis

Xiao

Xia

2021

Front. Immunol.

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“…This premise was further supported by the findings of Aiad et al in 2012 (Aiad et al, 2012), when they studied the skin of patients with psoriasis and demonstrated that in unaffected skin, SP-A was restricted to the basal layer; however, in psoriatic skin, it predominantly appeared in suprabasal layers. Dermal inflammatory cells showed SP-A in about half the cases studied.…”

Section: Review Of the Localization And Known Functions Of Extra-psupporting

confidence: 55%

Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins

Vieira

Kung

Bhatti

2017

Annals of Anatomy - Anatomischer Anzeiger

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The collectins family encompasses several collagenous Ca2+-dependent defense lectins that are described as pathogen recognition molecules. They play an important role in both adaptive and innate immunity. Surfactant protein A and D are two of these proteins which were initially discovered in association with surfactant in the pulmonary system. The structure, immune and inflammatory functions, and genetic variations have been well described in relation to their roles, function and pathophysiology in the pulmonary system. Subsequently, these proteins have been discovered in a wide range of other organs and organ systems. The role of these proteins outside the pulmonary system is currently an active area of research. This review intends to provide a current overview of the genetics, structure and extra-pulmonary functions of the surfactant collectin proteins.

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Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes

et al. 2016

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CD245 is a human surface antigen expressed on peripheral blood lymphocytes, initially delineated by two monoclonal antibodies DY12 and DY35. Until now, CD245 molecular and functional characteristics remained largely unknown. We combined immunological and proteomic approaches and identified CD245 as the unconventional myosin 18A, a highly conserved motor enzyme reported as a receptor for the surfactant protein A (SP-A), that plays a critical role in cytoskeleton organization and Golgi budding. We report that the recruitment of CD245 strongly enhanced NK cell cytotoxicity. Further, we show that the enhancement of the NK lymphocytes killing ability toward CD137-ligand expressing target cells could result from the induction of CD137 expression following CD245 engagement. The SP-A receptor could therefore represent a novel and promising target in cancer immunotherapy.

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Immunohistochemical Staining of Surfactant Proteins A and B in Skin of Psoriatic Patients Before and After Narrow-Band UVB Phototherapy

Abstract: SP-A and SP-B positivity is increased in psoriatic skin and reduced after NB-UVB therapy. Absence of SP-A in suprabasal layers after NB-UVB therapy is associated with better response and shorter duration of treatment.

Cited by 4 publications

References 34 publications

A Plausible Role for Collectins in Skin Immune Homeostasis

A Plausible Role for Collectins in Skin Immune Homeostasis

Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins

Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes

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