Immunohistochemical Localization of Vascular Endothelial Growth Factor (VEGF) and its Two Specific Receptors, Flt-1 and KDR, in the Porcine Placenta and Non-pregnant Uterus

Winther, Henrik; Ahmed, Asif; Dantzer, V.

doi:10.1053/plac.1998.0350

Cited by 94 publications

(67 citation statements)

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“…Thus, stronger response to VEGF than to PlGF may be a consequence of the fact that the latter factor acts via VEGFR-1 only, while VEGF binds both VEGFR-1 and VEGFR-2 [30,31]. It should be considered that in the placenta both endothelial and non-endothelial cells express the VEGF receptors [32,33].…”

Section: Discussionmentioning

confidence: 99%

Isolated Placental Vessel Response to Vascular Endothelial Growth Factor and Placenta Growth Factor in Normal and Growth-Restricted Pregnancy

Szukiewicz¹,

Szewczyk²,

Wątroba³

et al. 2005

Gynecol Obstet Invest

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Vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF) cause vasodilation. We examined the vasomotor response of isolated placental vessels to VEGF and PlGF in normal (group I) and intrauterine growth retardation (IUGR)-complicated pregnancy (group II). Rings of vessels were prepared in vitro and mounted on the vessel myograph plunged in tissue bath. The magnitude of dilation to increased doses of VEGF and PlGF has been studied. VEGF is a more potent vasodilator than PlGF. Both, VEGF- and PlGF-induced vasorelaxation was diminished in the IUGR (group II) nearly by half, compared to control (group I). Relative placental nitric oxide deficiency, or decreased sensitivity to VEGF and PlGF may contribute to the development of high impedance fetoplacental circulation.

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Section: Discussionmentioning

confidence: 99%

Isolated Placental Vessel Response to Vascular Endothelial Growth Factor and Placenta Growth Factor in Normal and Growth-Restricted Pregnancy

Szukiewicz¹,

Szewczyk²,

Wątroba³

et al. 2005

Gynecol Obstet Invest

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“…Decidua is not induced and conceptus attachment is required for uNK cell recruitment. uNK cells have only been studied over the first 35 of 114 days of porcine gestation with functional activity (target killing) and enrichment (1,5) reported between gestation days (gd) [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Murine uNK cells make substantial contributions to maternal arterial changes by mechanisms that include production of IFN-␥ (6) and synthesis of hypoxia-inducible factor 1-␣ (HIF-1␣)-regulated vascular endothelial growth factor (VEGF) (7,8).…”

mentioning

confidence: 99%

“…Fertilized ova develop as spheres until gd10, then undergo rapid elongation and attach to noneroded endometrial epithelium between gd11-13 (11). Maternal angiogenesis is initiated at gd15 (12,13). In commercial pigs, significant conceptus loss (ϳ30%) occurs during the attachment and immediate postattachment intervals (gd15-30).…”

mentioning

confidence: 99%

Differential Gene Expression in Endometrium, Endometrial Lymphocytes, and Trophoblasts during Successful and Abortive Embryo Implantation

Tayade

Black

Yuan

et al. 2006

The Journal of Immunology

111

134

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Prenatal mortality reaching 30% occurs during the first weeks of gestation in commercial swine. Mechanisms for this are unknown although poor uterine blood supply has been postulated. In other species, vascular endothelial growth factor, hypoxia-inducible factor 1-α, and IFN-γ regulate gestational endometrial angiogenesis. Vascular endothelial growth factor and hypoxia-inducible factor 1-α are also important for placental angiogenesis while trophoblastic expression of Fas ligand is thought to protect conceptuses against immune-mediated pregnancy loss. In this study, we document dynamic, peri-implantation differences in transcription of genes for angiogenesis, cytokine production, and apoptosis regulation in the endometrium, and laser capture microdissected endometrial lymphocytes and trophoblasts associated with healthy or viable but arresting porcine fetuses. In healthy implantation sites, endometrial gene expression levels differed between anatomic subregions and endometrial lymphocytes showed much greater transcription of angiogenic genes than trophoblasts. In arresting fetal sites, uterine lymphocytes had no angiogenic gene transcription and showed rapid elevation in transcription of proinflammatory cytokines Fas and Fas ligand while trophoblasts showed elevated transcription of IFN-γ and Fas. This model of experimentally accessible spontaneous fetal loss, involving blocked maternal angiogenesis, should prove valuable for further investigations of peri-implantation failure of normally conceived and surgically transferred embryos in many species, including the human.

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“…Furthermore, the localization of VEGF and bFGF receptors in maternal and fetal epithelial and stromal cells suggests that both growth factors might have other biological actions in the bovine placental tissue. In fact, the spatialtemporal distribution of VEGF-A and bFGF systems during gestation indicates that these growth factors play different roles in the placenta (Winther et al, 1999;Pfarrer et al, 2006a,b). We identi-.…”

Section: Discussionmentioning

confidence: 99%

Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term

Campos¹,

Papa²,

Marques³

et al. 2010

Genet. Mol. Res.

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Immunohistochemical Localization of Vascular Endothelial Growth Factor (VEGF) and its Two Specific Receptors, Flt-1 and KDR, in the Porcine Placenta and Non-pregnant Uterus

Cited by 94 publications

References 0 publications

Isolated Placental Vessel Response to Vascular Endothelial Growth Factor and Placenta Growth Factor in Normal and Growth-Restricted Pregnancy

Isolated Placental Vessel Response to Vascular Endothelial Growth Factor and Placenta Growth Factor in Normal and Growth-Restricted Pregnancy

Differential Gene Expression in Endometrium, Endometrial Lymphocytes, and Trophoblasts during Successful and Abortive Embryo Implantation

Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term

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