Immunohistochemical localization of basement membrane type IV collagen in invasive and metastatic squamous carcinomas of the head and neck

Carter, R. L.; Burman, Jonas; Barr, Lester; Gusterson, Barry A.

doi:10.1002/path.1711470303

Cited by 52 publications

(16 citation statements)

References 8 publications

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“…Mechanisms involved in basement membrane loss in the carcinomatous tissue remain unclear. It has been suggested that this loss is due to a lack or to a decrease of synthesis, decreased assembly, and increased turnover or degradation of basement membrane components by the tumor cells Daneker et al, 1987;Carter et al, 1985). The results of the present study revealed that such an event may occur not only in FIGURE 4 -Absence of basement membrane in the areas showing dense stromal inflammatory cell infiltration.…”

Section: Discussionmentioning

confidence: 54%

Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study

Mori

Shimono

Kido

et al. 1991

Intl Journal of Cancer

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The distribution of basement membrane components, type-IV collagen and laminin, was studied immunohistochemically in human samples of normal, hyperplastic, dysplastic and carcinomatous esophageal tissue. The expression of basement membrane components in normal, hyperplastic, and mildly and moderately dysplastic mucosa was characterized by a thick, continuous and linear staining pattern. In severe dysplasia and carcinoma in situ, the basement membrane was thinner and occasionally discontinuous. The distribution of basement membrane in invasive carcinomas varied greatly; well-differentiated, cohesive tumors had a basement membrane, however, poorly-differentiated tumors showing irregular cords, or individual cell infiltration, lacked this membrane at the tumor-stromal interface. Many moderately-differentiated tumors showed probable immature assembly of basement membrane components. The expression of basement membrane was also influenced by the extent of stromal inflammation. The absence or presence (staining pattern) of basement membrane components in esophageal squamous-cell carcinoma did not correlate with the survival rate, but did correlate with the histologic differentiation of epithelial organization.

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Section: Discussionmentioning

confidence: 54%

Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study

Mori

Shimono

Kido

et al. 1991

Intl Journal of Cancer

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“…These co-localizations were not observed in normal mucosa. In OSCC, the formation of a basement membrane, especially in welldifferentiated carcinomas, has been known for a long time (Carter et al 1985). Haas et al (2001) reported an increased expression of Ln-5 in hyperplastic oral mucosa as compared to normal subjects.…”

Section: Discussionmentioning

confidence: 99%

Complex formation of the laminin-5 γ2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front

Franz

Hansen

Richter

et al. 2005

Histochem Cell Biol

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Invasion and metastasis in oral squamous cell carcinoma (OSCC) are associated with changes in the extracellular matrix (ECM). We have previously shown an extracellular co-deposition of laminin-5 (Ln-5) and large unspliced tenascin-C (Tn-C(L)) in OSCC. Using a co-culture model of hTERT-BJ1 fibroblasts and the OSCC cell line PE/CA-PJ15, we demonstrate in the present study that Ln-5 and Tn-C(L) are not only co-deposited, but also form a physical complex which can be recovered by co-immunoprecipitation. In agreement with these results, examination of OSCC tissue specimens of different malignancy grade by means of confocal laser scanning microscopy revealed different patterns of Ln-5 and Tn-C(L) co-localization implicating complex formation also in vivo. A ribbon like co-localization was detected in subepithelial basement membranes around well differentiated OSCC parts and tumor clusters. Furthermore, a fibrillar Ln-5 gamma2 chain/Tn-C(L) co-localization occurred in the carcinoma stroma beneath tumor clusters. Additionally, at the site of ruptured basement membranes there were dot or strand like co-deposits of both molecules, but co-localizations were only rarely detectable. These different patterns may reflect a sequential modulation and reorganization of the ECM in the tumor/stroma interface as it occurs in different stages of OSCC invasion.

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“…It has been suggested that BM is comprised of various components, including collagens, laminin, fibronectin etc. Among them, type IV collagen acts as the basic skeleton with all of the other components attaching onto it [8][9][10]. Recently, there have been several studies about the distribution pattern of BM in different organs but the conclusions are controversial.…”

Section: Introductionmentioning

confidence: 99%

Distribution of Basement Membrane in Supraglottic Carcinoma

Wang

Sun

Chen

et al. 2010

Pathol. Oncol. Res.

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The object of this study was to assess the distribution of basement membrane in supraglottic squamous cell carcinomas. Expression of type IV collagen was detected by immunohistochemistry in resected supraglottic squamous cell carcinomas, and the correlation was examined between expression of type IV collagen and clinicopathological factors and cervical lymph node metastasis of supraglottic squamous cell carcinomas patients. An intact, continuous basement membrane was found in 17 cases (42.5%), while partial or widespread loss of the basement membrane was detected in the other 23 cases (57.5%). Heavily defective basement membrane was much more frequently observed in cases with poor histological differentiation (P < 0.05). Cases with BM destruction were more likely to be accompanied by cervical lymph node metastasis (P < 0.05). These data suggest that assessing the distribution pattern of basement membrane may be helpful in evaluating the malignancy grading of supraglottic squamous cell carcinomas and the potential occurrence of cervical lymph node metastasis.

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Immunohistochemical localization of basement membrane type IV collagen in invasive and metastatic squamous carcinomas of the head and neck

Cited by 52 publications

References 8 publications

Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study

Distribution of basement membrane antigens in human esophageal lesions: An immunohistochemical study

Complex formation of the laminin-5 γ2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front

Distribution of Basement Membrane in Supraglottic Carcinoma

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