Immunohistochemical localization of alpha1a-adrenoreceptors in muscle spindles of rabbit masseter muscle

Bombardi, Cristiano; Grandis, Annamaria; Chiocchetti, Roberto; Bortolami, R.; Johansson, Håkan; Lucchi, Maria Luisa

doi:10.1016/j.tice.2005.12.003

Cited by 22 publications

(24 citation statements)

References 20 publications

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“…These data support Passatore data and suggest that sympathetic nervous system could modulate the spindle afferent discharge by altering intrafusal fiber mechanics [33]. Increase in SNS outflow may act by: 1. decreasing muscle blood perfusion, which is an inseparable factor of muscle pain; 2. enhancing contractile force in fast-contracting muscle, while exerting a fatiguing action on slow-contracting ones; 3. reducing the quality of proprioceptive information.…”

Section: Resultssupporting

confidence: 85%

“…Recent immunohistochemical data on masseter muscle confirmed the presence of non vascular sympathetic innervation on muscle spindles in close association with intrafusal muscle fibers [33]. These data support Passatore data and suggest that sympathetic nervous system could modulate the spindle afferent discharge by altering intrafusal fiber mechanics [33].…”

Section: Resultssupporting

confidence: 61%

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Effects of intervertebral disc disorders of low back on the mandibular kinematic: kinesiographic study

et al. 2014

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BackgroundIntervertebral disc disorders are one of the most common causes of low back pain. Neuromuscular dysfunction frequently is present in patients with lumbar disc herniation.When considering joint dysfunction, it is important to remember that the spine functions as a unit. Dysfunction on one level can trigger compensatory changes in other spinal levels or in other areas of the musculoskeleton. Findings demonstrated the relationship between stomatognathic and postural systems justifying the hypothesis that muscular-skeletal impairment in one system could affect the other one. However, evidence that a lumbar intervertebral disc herniation could influence the mandibular kinematics is still lacking. Aim of this study was to analyse the effects that intervertebral disc herniation of low back could have on the mandibular kinematics.FindingsKinesiographic evaluations of the mandibular dynamics of 23 adult patients suffering L4/L5 and L5/S1 lumbosacral disc hernation were compared with a non pathological control group. A statistically significant difference of maximal mouth opening (p < .05) and of maximal mouth opening velocity (p < .03) was found comparing the study patients with the control subjects.ConclusionLumbosacral disc herniation appears to be associated with changes in the activity of mandibular kinematics both in rate and quality of movement. The study suggests the existence of connections between masticatory system and lumbar disk herniation.

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Section: Resultssupporting

confidence: 85%

Section: Resultssupporting

confidence: 61%

Effects of intervertebral disc disorders of low back on the mandibular kinematic: kinesiographic study

et al. 2014

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“…Increased activity of the sympathetic nervous system might exacerbate these processes and cause MTrP formation. The sympathetic nervous system controls extrafusal and intrafusal muscle fibers through collateral branches (Selkowitz, 1992; Bombardi et al, 2006), and enhances the release of acetylcholine from motor nerve terminals that is mediated by α- and β-adrenoceptors on motor nerve terminals (Gerwin et al, 2004). …”

Section: Discussionmentioning

confidence: 99%

Compression at Myofascial Trigger Point on Chronic Neck Pain Provides Pain Relief through the Prefrontal Cortex and Autonomic Nervous System: A Pilot Study

et al. 2017

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Compression at myofascial trigger points (MTrPs), known as “ischemic compression,” has been reported to provide immediate relief of musculoskeletal pain and reduce the sympathetic activity that exacerbates chronic pain. We conducted a pilot study to investigate the possible involvement of the prefrontal cortex in pain relief obtained by MTrP compression in the present study, and analyzed the relationships among prefrontal hemodynamic activity, activity of the autonomic nervous system, and subjective pain in patients with chronic neck pain, with and without MTrP compression. Twenty-one female subjects with chronic neck pain were randomly assigned to two groups: MTrP compression (n = 11) or Non-MTrP compression (n = 10). Compression for 30 s was conducted 4 times. During the experiment, prefrontal hemodynamic activity [changes in Oxy-hemoglobin (Hb), Deoxy-Hb, and Total-Hb concentrations] and autonomic activity based on heart rate variability (HRV) were monitored by using near infrared spectroscopy (NIRS) and electrocardiography (ECG), respectively. The results indicated that MTrP compression significantly reduced subjective pain compared with Non-MTrP compression. The spectral frequency-domain analyses of HRV indicated that a low frequency (LF) component of HRV was decreased, and a high frequency (HF) component of HRV was increased during MTrP compression, while LF/HF ratio was decreased during MTrP compression. In addition, prefrontal hemodynamic activity was significantly decreased during MTrP compression compared with Non-MTrP compression. Furthermore, changes in autonomic activity were significantly correlated with changes in subjective pain and prefrontal hemodynamic activity. Along with previous studies indicating a role for sympathetic activity in the exacerbation of chronic pain, the present results suggest that MTrP compression in the neck region alters the activity of the autonomic nervous system via the prefrontal cortex to reduce subjective pain.

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“…A conclusive support for a direct control operated by the sympathetic innervation on muscle spindle is provided by the recently reported presence of adrenergic receptors on the surface of the large majority of intrafusal muscle Wbres (Bombardi et al 2006), in rabbit masticatory muscles. Bombardi et al( 2006) conWrm the presence of sympathetic Wbres, visualized by immunoXuorescent labelling of the noradrenaline-synthesizing enzymes tyrosine hydroxylase and dopamine betahydroxylase, along the entire length of the spindles, within the capsule lamellar layers or within the periaxial Xuid space and in close apposition to intrafusal Wbres. In addition a high density of 1a -adrenoreceptors is revealed by immunohistochemical Xuorescent method, at the polar region of both bag and chain intrafusal Wbres, in 88.1% of the muscle spindles tested.…”

Section: A Debated Issuementioning

confidence: 91%

Influence of sympathetic nervous system on sensorimotor function: whiplash associated disorders (WAD) as a model

2006

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There is increasing interest about the possible involvement of the sympathetic nervous system (SNS) in initiation and maintenance of chronic muscle pain syndromes of different aetiology. Epidemiological data show that stresses of different nature, e.g. work-related, psychosocial, etc., typically characterised by SNS activation, may be a co-factor in the development of the pain syndrome and/or negatively affect its time course. In spite of their clear traumatic origin, whiplash associated disorders (WAD) appear to share many common features with other chronic pain syndromes affecting the musculo-skeletal system. These features do not only include symptoms, like type of pain or sensory and motor dysfunctions, but possibly also some of the pathophysiological mechanisms that may concur to establish the chronic pain syndrome. This review focuses on WAD, particular emphasis being devoted to sensorimotor symptoms, and on the actions exerted by the sympathetic system at muscle level. Besides its well-known action on muscle blood flow, the SNS is able to affect the contractility of muscle fibres, to modulate the proprioceptive information arising from the muscle spindle receptors and, under certain conditions, to modulate nociceptive information. Furthermore, the activity of the SNS itself is in turn affected by muscle conditions, such as its current state of activity, fatigue and pain signals originating in the muscle. The possible involvement of the SNS in the development of WAD is discussed in light of the several positive feedback loops in which it is implicated.

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Immunohistochemical localization of alpha1a-adrenoreceptors in muscle spindles of rabbit masseter muscle

Cited by 22 publications

References 20 publications

Effects of intervertebral disc disorders of low back on the mandibular kinematic: kinesiographic study

Effects of intervertebral disc disorders of low back on the mandibular kinematic: kinesiographic study

Compression at Myofascial Trigger Point on Chronic Neck Pain Provides Pain Relief through the Prefrontal Cortex and Autonomic Nervous System: A Pilot Study

Influence of sympathetic nervous system on sensorimotor function: whiplash associated disorders (WAD) as a model

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