Immunohistochemical localization and possible functions of nesfatin-1 in the testis of mice during pubertal development and sexual maturation

Ranjan, Amit; Choubey, Mayank; Yada, Toshihiko; Krishna, Amitabh

doi:10.1007/s10735-019-09846-8

Cited by 23 publications

(15 citation statements)

References 58 publications

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“…77 Moreover, nesfatin-1 promotes puberty, spermatogenesis and steroid production in pre-pubertal male mice by directly acting on the testes, accompanied by reduced oxidative stress. 78 Similarly, the stimulatory effects of nesfatin-1 on spermatogenesis and steroidogenesis may be related to its antioxidant and antiapoptotic activities. 79 Further, it ameliorates the type-2 diabetes mellitus (T2DM)-associated testicular dysfunction and decreases the production of antioxidative enzymes in mice with T2DM.…”

Section: Other Diseasesmentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Other Diseasesmentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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“…In line with this, it was further shown that nesfatin-1 suppresses peripheral artery remodeling likely by increasing NO production and LKB1-mediated activation of AMPK in vascular endothelial cells in mice (54). However, in the testis of mice nesfatin-1-induces an increase in G protein-coupled receptor 54 (GPR-54) accompanied by increases in PCNA, Bcl2, androgen receptor (AR), GLUT8, insulin receptor and gonadotropin-releasing hormone receptor (GnRH-R) (64,65). In addition, a potential role of protein kinase B (AKT) as a signaling mechanism for nesfatin-1induced glucose uptake and activation of the AMP-activated protein kinase (AMPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) system was found through which nesfatin-1 enhances insulin sensitivity in the testis of mice (64,66).…”

Section: Ampk Signaling Pathwaymentioning

confidence: 99%

Nesfatin-1 Receptor: Distribution, Signaling and Increasing Evidence for a G Protein-Coupled Receptor – A Systematic Review

Rupp¹,

Wölk

Stengel

2021

Front. Endocrinol.

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BackgroundNesfatin-1 is an 82-amino acid polypeptide, cleaved from the 396-amino acid precursor protein nucleobindin-2 (NUCB2) and discovered in 2006 in the rat hypothalamus. In contrast to the growing body of evidence for the pleiotropic effects of the peptide, the receptor mediating these effects and the exact signaling cascades remain still unknown.MethodsThis systematic review was conducted using a search in the Embase, PubMed, and Web of Science databases. The keywords “nesfatin-1” combined with “receptor”, “signaling”, “distribution”, “pathway”, g- protein coupled receptor”, and “binding” were used to identify all relevant articles reporting about potential nesfatin-1 signaling and the assumed mediation via a Gi protein-coupled receptor.ResultsFinally, 1,147 articles were found, of which 1,077 were excluded in several steps of screening, 70 articles were included in this systematic review. Inclusion criteria were studies investigating nesfatin-1’s putative receptor or signaling cascade, observational preclinical and clinical studies, experimental studies, registry-based studies, cohort studies, population-based studies, and studies in English language. After screening for eligibility, the studies were assigned to the following subtopics and discussed regarding intracellular signaling of nesfatin-1 including the potential receptor mediating these effects and downstream signaling of the peptide.ConclusionThe present review sheds light on the various effects of nesfatin-1 by influencing several intracellular signaling pathways and downstream cascades, including the peptide’s influence on various hormones and their receptors. These data point towards mediation via a Gi protein-coupled receptor. Nonetheless, the identification of the nesfatin-1 receptor will enable us to better investigate the exact mediating mechanisms underlying the different effects of the peptide along with the development of agonists and antagonists.

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“…Chronic ip treatment with nesfatin-1 in vivo had various effects on gonadal function in pubertal male mice [248]. Firstly, it increased the expression of proteins involved in steroid hormone production including LH-R, StAR, P450scc, 3β-HSD and 17β-HSD proteins as well as markers of spermatogenesis such as bcl2, inducing cell survival and PCNA promoting proliferation [248]. These changes resulted in stimulation of testis maturation [248].…”

Section: Testismentioning

confidence: 99%

“…Firstly, it increased the expression of proteins involved in steroid hormone production including LH-R, StAR, P450scc, 3β-HSD and 17β-HSD proteins as well as markers of spermatogenesis such as bcl2, inducing cell survival and PCNA promoting proliferation [248]. These changes resulted in stimulation of testis maturation [248]. Moreover, this treatment stimulated the expression of testicular super oxide dismutase, catalase, and glutathione peroxidase enzyme activities, leading to decreased oxidative stress [248].…”

Section: Testismentioning

confidence: 99%

“…These changes resulted in stimulation of testis maturation [248]. Moreover, this treatment stimulated the expression of testicular super oxide dismutase, catalase, and glutathione peroxidase enzyme activities, leading to decreased oxidative stress [248]. In addition, chronic nesfatin-1 treatment increased the expression of insulin receptor and GLUT8 proteins and in intra-testicular glucose concentration and LDH activity in pubertal mice [248,249], which could be responsible for enhanced transport of energy substrates ameliorating spermatogenesis and steroidogenesis; however, this warrants further research.…”

Section: Testismentioning

confidence: 99%

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The Role of the Gastric Hormones Ghrelin and Nesfatin-1 in Reproduction

Schalla

Stengel

2021

IJMS

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Ghrelin and nesfatin-1 are enteroendocrine peptide hormones expressed in rat X/A-like and human P/D1cells of the gastric mucosa. Besides their effect on food intake, both peptides are also implicated in various other physiological systems. One of these is the reproductive system. This present review illustrates the distribution of ghrelin and nesfatin-1 along the hypothalamus–pituitary–gonadal (HPG) axis, their modulation by reproductive hormones, and effects on reproductive functions as well as highlighting gaps in current knowledge to foster further research.

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Immunohistochemical localization and possible functions of nesfatin-1 in the testis of mice during pubertal development and sexual maturation

Cited by 23 publications

References 58 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Nesfatin-1 Receptor: Distribution, Signaling and Increasing Evidence for a G Protein-Coupled Receptor – A Systematic Review

The Role of the Gastric Hormones Ghrelin and Nesfatin-1 in Reproduction

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