Immunohistochemical Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor in Canine Cutaneous Fibrosarcomas

Al-Dissi, Ahmad; Haines, Deborah M.; Singh, Baljit; Kidney, Beverly A.

doi:10.1016/j.jcpa.2009.05.004

Cited by 46 publications

(67 citation statements)

References 43 publications

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“…It is thought that in this case the intestinal content induced an inflammatory reaction, which in turn led to stimulated neoplastic transformation, resulting in a fibrosarcoma, as reported in the literature (Doddy et al 1996;Macy et al 1996;Madewell et al 2001;Rayner et al 2010). It was reported that this transformation and development was derived from mutagenic reactive oxygen and nitrogen species released from macrophages, cytokines and growth factors, which all have tumour-inducing properties (Martin 2003;Moizhess 2008;Al-Dissi et al 2009). Therefore, in such cases where the intestinal wall is not completely disrupted, the early diagnosis and treatment of ulcers is of great clinical importance as they are predisposing factors in the development of malignant tumours.…”

Section: Discussionmentioning

confidence: 84%

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Avcı¹,

Yaygingül²,

Gültekin³

et al. 2012

Vet. Med. - Czech

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An 11-year-old male Cocker Spaniel was examined for a palpable abdominal mass located in the jejunum after presenting with a history of anorexia and constipation for several weeks. In a contrast radiogram, a structure with well-defined borders adjacent to the intestine was determined. The intestinal mass, measuring 16 × 9.19 × 8.6 cm and weighing 900 g was surgically removed. At gross examination, when the lumen of a portion of the intestine excised together with the tumour mass was exposed, an ulcerated, oval-shaped area 1.2 × 0.6 cm in size was observed on the mucosa. The outer surface of the tumour was homogenous and expanded outwards from the intestinal wall. Histologically, the tumour was composed of fusiform-elongated spindle-shaped to polygonal neoplastic cells forming interlacing fascicles or interwoven bundles in an atypical herringbone pattern. Immnunohistochemically, neoplastic cells stained intensely positive for vimentin, and negative for α-SMA, desmin, cyotokeratin (AE1/AE3), S-100 protein, glial fibrillary acidic protein, neuron specific enolase and synaptophsin. On the basis of the histopathological and immunohistochemical results, the tumour was diagnosed as a fibrosarcoma. The present report is a very rare description of fibrosarcoma of the dog intestine associated with intestinal perforation.

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Section: Discussionmentioning

confidence: 84%

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Avcı¹,

Yaygingül²,

Gültekin³

et al. 2012

Vet. Med. - Czech

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“…Paraffin-embedded tumor tissues were immunohistochemically stained with indicated primary antibodies and streptavidin-conjugated horseradish peroxidase (HRP) secondary antibodies as described previously (Al-Dissi et al 2010). PBS was replaced with a primary antibody to serve as negative control.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Effects of recombinant human endostatin and its synergy with cisplatin on circulating endothelial cells and tumor vascular normalization in A549 xenograft murine model

Zheng²,

Wei

et al. 2012

J Cancer Res Clin Oncol

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Rh-endostatin could transiently normalize tumor vasculature, probably via regulation of both pro- and anti-angiogenesis factors. The synergistic efficacy of anti-angiogenesis and chemotherapy was found during "the normalization window". CEC could be a feasible blood biomarker for defining "vascular normalization window" and providing the evidence to make an optimizing combination therapeutic schedule in human tumor.

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“…The slides were scored based on the proportion of positive cells and the intensity of the staining. Cells considered positive were scored as: 0 (0% positive), 1 (1-30% positive), 2 (31-70% positive), or 3 (71-100% positive) [15][16][17]. Staining intensity scores were as follows: 1 (light brown), 2 (yellowish brown), or 3 (dark brown).…”

Section: Pathological Evaluationmentioning

confidence: 99%

Regulatory T cells increase in breast cancer and in stage IV breast cancer

Wang

Yang

Liu

et al. 2011

Cancer Immunol Immunother

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Expression levels of VEGF and Her-2, levels of T-regulatory (Treg) cells, levels of CD3+ cells, and ratios of Th (CD4+ T cells)/Tr (Treg) cells were compared between stage I, II, III, and IV breast cancer patients (n = 120) prior to chemotherapy and healthy women (n = 30). Cells from peripheral blood were counted by flow cytometry, Her-2 and VEGF expression was detected by pathological examination, and Her-2 was detected by FISH. Breast cancer patients had more Treg cells and a lower ratio of Th/Tr cells than the healthy women. Stage IV breast cancer patients had more Treg cells and a lower ratio of Th/Tr cells than stage I, II, or III breast cancer patients. Patients positive for VEGF had a lower ratio of Th/Tr cells compared with patients negative for VEGF, and those positive for both VEGF and Her-2 also had a lower ratio of Th/Tr cells compared with patients not positive for both VEGF and Her-2. The decreased Th/Tr cells ratio indicates impaired immune function, suggesting that the stage IV breast cancer and the Her-2/VEGF-positive breast cancer patients have lower immune function.

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Immunohistochemical Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor in Canine Cutaneous Fibrosarcomas

Cited by 46 publications

References 43 publications

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: a case report

Effects of recombinant human endostatin and its synergy with cisplatin on circulating endothelial cells and tumor vascular normalization in A549 xenograft murine model

Regulatory T cells increase in breast cancer and in stage IV breast cancer

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