Immunohistochemical expression of K6, K8, K16, K17, K19, maspin, syndecan-1 (CD138), α-SMA, and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations

Safadi, Rima A.; Quda, Basma F.; Hammad, Huda M.

doi:10.1016/j.oooo.2015.11.015

Cited by 26 publications

(29 citation statements)

References 36 publications

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“…In the present study, we assessed 17 newly reported cases of maxillary AC from 2009 to 2017 (see Table 1). [2,6,[8][9][10][11][12][13] The age ranges from 21 to 77 years (mean age: 57.1 years) and the male to female ratio was 7.5:1, which was consistent with the Kruse et al report. [3] Most of the lesions (88.2%) similar to the present case and to previously reported cases occurred in the posterior portion of the maxilla.…”

Section: Discussionsupporting

confidence: 89%

“…The underlying mechanism of carcinogenesis in secondary type is not clear. [2] With respect to malignancy, the difference between AC and malignant ameloblastoma must be considered. The term "AC" must be reserved for an ameloblastoma that has atypical histologic features in the primary tumor, in a recurrence or in any metastatic deposit whereas malignant ameloblastoma is confined to a metastasizing tumor which is a histologically classic ameloblastoma.…”

Section: Discussionmentioning

confidence: 99%

“…A Ki-67 score (75 cells/HPF) is an indicator of AC. [2,5,6] According to the literature, AC affects males more frequently and the predilection age is 50-60 years. Two thirds of the reported cases are in the mandible.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis from AC is found most often in the lung and the cervical lymph nodes are the second most common site for metastasis. [2,4,7] Kruse et al reviewed 26 cases of maxillary AC over the last 60 years . In the present study, we assessed 17 newly reported cases of maxillary AC from 2009 to 2017 (see Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…To date, 92 cases of AC have been presented in the literature showing its rarity. [2] According to Kruse et al study, 67% of ACs are located in the mandible. Maxillary ACs are extremely rare.…”

Section: Introductionmentioning

confidence: 99%

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Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Sargolzaei

Khaleghjoo

Taghavi

2017

JST

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Sargolzaei

Khaleghjoo

Taghavi

2017

JST

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Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

et al. 2019

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Ameloblastic carcinoma (AC) is defined as a rare primary epithelial odontogenic malignant neoplasm and the malignant counterpart of benign epithelial odontogenic tumor of ameloblastoma (AB) by the WHO classification. AC develops pulmonary metastasis in about one third of the patients and reveals a poor prognosis. However, the mechanisms of AC oncogenesis remain unclear. In this report, we aimed to clarify the mechanisms of malignant transformation of AB or AC carcinogenesis. The relatively important genes in the malignant transformation of AB were screened by DNA microarray analysis, and the expression and localization of related proteins were examined by immunohistochemistry using samples of AB and secondary AC. Two genes of hypoxia‐inducible factor 1 alpha subunit (HIF1A) and zinc finger E‐box‐binding homeobox 1 (ZEB1) were significantly and relatively upregulated in AC than in AB. Both genes were closely related in hypoxia and epithelial‐mesenchymal transition (EMT). In addition, expressions of HIF‐1α and ZEB1 proteins were significantly stronger in AC than in AB. In the cell assays using ameloblastoma cell line, AM‐1, hypoxia condition upregulated the expression of transforming growth factor‐β (TGF‐β) and induced EMT. Furthermore, the hypoxia‐induced morphological change and cell migration ability were inhibited by an antiallergic medicine tranilast. Finally, we concluded that hypoxia‐induced HIF‐1α and ZEB1 were critical for the malignant transformation of AB via TGF‐β‐dependent EMT. Then, both HIF‐1α and ZEB1 could be potential biomarkers to predict the malignant transformation of AB.

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Ameloblastic carcinoma: Clinicopathological analysis of 18 cases and a systematic review

Deng

Wang

et al. 2019

Head & Neck

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Objectives Exploring the clinicopathological features of ameloblastic carcinoma (AC) and reviewing the literature to improve the diagnosis and treatment of the disease. Materials and Methods Clinical data and pathological features of 18 cases of AC were retrospectively analyzed. A systematic review was carried out by searching PubMed and Medline databases using the MeSH terms “ameloblastic” and “carcinoma.” Results In the systematic analysis, 125 cases of AC from 81 eligible original studies and 18 cases of AC from this research were included. The male‐to‐female ratio was 2.58:1, and the mandible‐to‐maxilla ratio was 1.80:1. Mean age of patients was 45.3 years. Thirty‐seven cases of recurrence and 27 cases of metastasis were recorded. Conclusion AC is a rare neoplasm of the odontogenic epithelium. A systematic review indicates that diagnoses at the early phase and a close periodic assessment for recurrence and metastasis are necessary.

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Immunohistochemical expression of K6, K8, K16, K17, K19, maspin, syndecan-1 (CD138), α-SMA, and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations

Cited by 26 publications

References 36 publications

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Ameloblastic carcinoma of the maxilla: A rare case presentation and a review of new cases

Hypoxia‐induced HIF‐1α and ZEB1 are critical for the malignant transformation of ameloblastoma via TGF‐β‐dependent EMT

Ameloblastic carcinoma: Clinicopathological analysis of 18 cases and a systematic review

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