Ameloblastic carcinoma: Clinicopathological analysis of 18 cases and a systematic review

Abstract

Objectives Exploring the clinicopathological features of ameloblastic carcinoma (AC) and reviewing the literature to improve the diagnosis and treatment of the disease. Materials and Methods Clinical data and pathological features of 18 cases of AC were retrospectively analyzed. A systematic review was carried out by searching PubMed and Medline databases using the MeSH terms “ameloblastic” and “carcinoma.” Results In the systematic analysis, 125 cases of AC from 81 eligible original studies and 18 cases of AC from this research were included. The male‐to‐female ratio was 2.58:1, and the mandible‐to‐maxilla ratio was 1.80:1. Mean age of patients was 45.3 years. Thirty‐seven cases of recurrence and 27 cases of metastasis were recorded. Conclusion AC is a rare neoplasm of the odontogenic epithelium. A systematic review indicates that diagnoses at the early phase and a close periodic assessment for recurrence and metastasis are necessary.

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

“…This was in accordance with previous studies. [23][24][25][26][27] Smoking induces oral cancer risk development [28] Cigarettes contains N-nitrosamines and nicotine which lead to DNA mutations. This mutation encourages tu-mor initiation and promotion.…”

Reconstruction of soft tissue defect after maxillectomy of ameloblastic carcinoma with submental island flap: a case report and literature review

“…The exclusion criteria were conference abstracts, reviews, and articles with unavailable full text. Eighteen full-length studies were extracted for inclusion, and clinical and radiographic features of AC were recorded (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

“…Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with characteristic histological features and clinical aggressive behavior that are distinct from a conventional ameloblastoma. The mandible is the most reported site, followed by the mandible, the ratio of occurrence of AC in mandible: maxilla was about 2-3:1 (1). We present a case of AC involving the maxillary region and systematically evaluated the literature to collect more information about AC.…”

“…The etiology of AC ameloblastic carcinoma has not been clearly elucidated till now. Most cases arise spontaneously without a previous history of cancer, while, few cases may develop from the malignant transformation of ameloblastoma (1).…”

Terapi Nutrisi Pada Karsinoma Ameloblastik Dengan Kemoterapi

“…Karsinoma ameloblastik adalah tumor ganas , dengan angka kejadian sekitar 2% dari tumor odontogenik. [1][2] Dalam beberapa kasus, sel epitel akan bertransformasi menjadi ganas dari ameloblastoma yang sudah ada atau dari kista odontogenik jinak. 3 Penelitian yang dilakukan oleh Rizzitelli,dkk menyatakan bahwa insiden terjadinya karsinoma ameloblastik pada anak-anak dan orang dewasa muda adalah 0,84 per 10 juta orang / tahun; dewasa, 2,5 per 10 juta orang / tahun dan lansia, 4,4 per 10 juta orang / tahun , kejadian juga secara signifikan lebih tinggi pada populasi kulit hitam dibandingkan pada populasi kulit putih.…”