Immunohistochemical expression of interleukin-2 receptor and interleukin-6 in patients with prostate cancer and benign prostatic hyperplasia: Association with asymptomatic inflammatory prostatitis NIH category IV

Engelhardt, Paul F.; Seklehner, Stephan; Brustmann, Hermann; Lusuardi, Lukas; Riedl, Claus R.

doi:10.3109/21681805.2014.971427

Cited by 19 publications

(19 citation statements)

References 34 publications

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“…Even though some of the literature has showed that CP/ CPPS is an important health issue in elder population, [25][26][27][28] the present study failed to observe such an association between CP/CPPS and previous colonoscopy in the elderly (≥60 years old). According to anatomical and physiological changes of the prostate in the elderly, a portion of the pathogenesis of prostate inflammation differs from that in young adults.…”

Section: Discussioncontrasting

confidence: 97%

“…We first excluded all subjects who had a history of CP/CPPS since the beginning of the NHI program in 1995. Thereafter, we selected 3933 controls matched with cases by age group (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)30-39, 40-49, 50-59, 60-69, and >69 years) and index year. We selected the controls by matching them to a given CP/CPPS case simply due to use of medical services in the same index year of that particular case.…”

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

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Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Tsai

Lin

Lee

et al. 2017

CUAJ

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Introduction: This study aimed to examine the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and receipt of a prior colonoscopic examination using a populationbased database. Methods: We used the Taiwan Longitudinal Health Insurance Database 2005 to retrieve the study sample. This study included 3933 patients with CP/CPPS and 3933 age-matched controls. We designated the date of receiving the first diagnosis of CP/CPPS as the index date for cases. We defined the first an ambulatory care visit occurring in the matched year as the index date for the controls. Conditional logistic regressions was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for having previously received colonoscopy between cases and controls. Results: We found that 349 (4.44%) of the 7866 sampled patients had previously undergone colonoscopy, including 223 (5.67%) cases and 126 (3.20%) controls (p<0.001). A conditional logistic regression analysis revealed that the adjusted OR of receiving a colonoscopy within three years before the index date was 1.77 (95% CI 1.42-2.23) for cases compared to controls. Furthermore, we found that the youngest group of cases (<40 years) had the greatest adjusted OR for having received colonoscopy within three years before the index date compared to controls (OR 2.81; 95% CI 1.45-5.44); however, in contrast, no significant difference in the adjusted odds of having previously received colonoscopy was observed between cases and controls among the oldest age group (≥60 years). Conclusions: We concluded that there was an association between antecedent colonoscopy and CP/CPPS.

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Section: Discussioncontrasting

confidence: 97%

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Tsai

Lin

Lee

et al. 2017

CUAJ

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“…The authors' previously published data about the incidence of NIH IV prostatitis revealed asymptomatic NIH IV prostatitis in 43.8% of the patients with PCa and 70.7% of the patients with BPH [14,30]. According to a PubMed search, the presented data analysis is the first showing a direct association between asymptomatic inflammatory prostatitis NIH category IV, the incidence of prostatic calcification and elevated TNF-a expression in patients with obstructive BPH treated by TURP.…”

Section: Discussionmentioning

confidence: 82%

“…Evidence for the importance of estrogen, by way of increasing interferon-mRNA and interleukin (IL-2, IL-4, IL-6, IL-7, IL-8 IL-15, IL-17) in BPH can be found [6][7][8][9][10]14]. Tumor necrosis factor-a (TNF-a) is an adipokine responsible for systemic inflammatory reactions.…”

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor-α expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification

Engelhardt¹,

Seklehner²,

Brustmann³

et al. 2015

Scandinavian Journal of Urology

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“…In gastric cancer cells, IL-1 may enhance the invasiveness of cancer cells through the IL-6 expression [63]. The immunohistochemical expression of IL-2 receptor and IL-6 is higher in prostate cancer tissue than in normal tissue [64]. IL-6 gene polymorphism is associated with increased risk of bladder cancer [65].…”

Section: The Rationale Of Developing Anti-il-6 For the Clinical Theramentioning

confidence: 99%

The Biological Effects of Interleukin-6 and Their Clinical Applications in Autoimmune Diseases and Cancers

Yang¹

2017

Rheumatica Acta: Open Access

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Interleukin-6 (IL-6) is one of the pro-infl ammatory cytokines involved in pathogenesis of various autoimmune and chronic infl ammatory diseases. IL-6 through binding to its cellular receptor can transduce both classical-and trans-signaling pathways. Overproduction of circulating IL-6 can be detected in patients with different autoimmune diseases. Tocilizumab, a humanized monoclonal antibody against IL-6 receptor, can block IL-6-mediated signaling and has been approved for the treatment of rheumatoid arthritis and Castleman's disease. Besides, expression of IL-6 may promote tumorigenesis and has been detected in various tumors, including multiple myeloma, colorectal cancer, breast cancer, lymphoma, breast cancer and lung cancer. Furthermore, increased levels of circulating IL-6 are associated with poor prognosis and cachexia in cancer patients. Monotherapy with IL-6 blockade or a combination therapy with both IL-6 blockade and conventional chemotherapy may reduce the progression of cancer and improve the status of cachexia in cancer patients. Finally, based upon the known biological effects of IL-6, diseases, other than autoimmune diseases and cancers, potentially to be anti-IL-6 candidates will be briefl y discussed.

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Immunohistochemical expression of interleukin-2 receptor and interleukin-6 in patients with prostate cancer and benign prostatic hyperplasia: Association with asymptomatic inflammatory prostatitis NIH category IV

Abstract: IL-2R and IL-6 expression was significantly higher in prostate cancer tissue than in normal tissue. Patients with asymptomatic inflammatory prostatitis NIH category IV showed significantly greater activity.

Cited by 19 publications

References 34 publications

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Chronic prostatitis/chronic pelvic pain syndrome is associated with previous colonoscopy

Tumor necrosis factor-α expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification

The Biological Effects of Interleukin-6 and Their Clinical Applications in Autoimmune Diseases and Cancers

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