Immunohistochemical Expression of E-Cadherin in Salivary Glands and Their Tumors.

Yamada, Kazuto; Kudeken, Wataru; Sumitomo, Shinichiro; Muramatu, Yasunori; Shiba, Takeshi; Takai, Yoshiaki; Mori, Masahiko; Speight, Paul M.

doi:10.1267/ahc.29.305

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…basal-lateral membranous compartment related to cellcell adhesion as well as their relationship to a myoepithelial cell compartment. Although not previously described in ACC of the breast, E-cad expression has been detected in cribriform areas in ACC in salivary glands 6 . The myoepithelial compartment in ACC is situated between the cells that line the true lumen and the surrounding stroma as in normal breast.…”

Section: Discussionmentioning

confidence: 62%

Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study

Kasami

et al. 1998

Histopathology

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ACC of the breast is characterized by the presence of two types of intercellular lumens, one conserving basolateral markers of normal polarity (epithelial) with the other containing basement membrane material (abutted by myoepithelial cells). Dominance of VM staining may be a hallmark of ACC, along with maintained epithelial and myoeithelial compartments. This status of advanced, normal differentiation despite local invasion may be responsible for lack of distant metastasis.

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Section: Discussionmentioning

confidence: 62%

Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study

Kasami

et al. 1998

Histopathology

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“…The expression of E-cadherin has been examined in a number of papers, focusing mainly on adenoid cystic carcinomas 21,22,34,35 and mucoepidermoid carcinomas 23 of salivary glands. Only Economopoulou et al 19 and Yamada et al 20 have detected E-cadherin expression in both benign and malignant salivary gland tumours, and Xin and Paulino 36 in the subtypes of malignant mixed tumours.…”

Section: E-cadherin In Salivary Gland Tumoursmentioning

confidence: 99%

“…5 The reduced or alternative expression of this molecule has been considered to be associated with carcinomas of the head and neck, 6,7 breast, 8 bladder, 9 skin 10 and lung 11 as well as with gastric, 12 prostatic, 13 intestinal, 14 oesophaegeal, 15 hepatic, 16 cervical 17 and pancreatic carcinomas. 18 There is limited information about the expression of E-cadherin in certain types of salivary gland tumours, 19,20 focused mainly on cases of adenoid cystic 21,22 and mucoepidermoid carcinoma. 23 The purpose of this study was to compare the immunoexpression and tissue distribution of E-cadherin in different types of benign and malignant tumours with that in other non-neoplastic salivary gland diseases and to note any possible correlation with the grade of malignant tumour differentiation.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours

et al. 2006

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“…Polymorphic epithelial mucin has been localized by monoclonal antibodies against MAM-3 and MAM-6 antigens in the columnar and basal cells of the EDs of the human parotid and submandibular glands; columnar cells are labeled by antibody against MAM-6, whereas basal cells are labeled by antibodies against MAM-3 (Yamada et al, 1989b(Yamada et al, , 1991Mori et al, 1992b). E-cadherin, a transmembrane glycoprotein that is involved in cellular adhesion, has been identified in human parotid and submandibular glands in the membranes of ED columnar cells and is strongly expressed in the basal cells (Yamada et al, 1996. E-cadherin is linked to actin molecules by ␤-catenin, which is a cytoplasmic protein that has been localized in the basal cells of the human parotid and submandibular gland EDs .…”

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confidence: 99%

Interlobular excretory ducts of mammalian salivary glands: Structural and histochemical review

2006

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In the major salivary glands of mammals, excretory ducts (EDs) succeed striated ducts. They are for the most part interlobular in position, although their proximal portions sometimes are on the periphery of a lobule, where they occasionally retain some of the structural features of striated ducts. Based on a survey of a broad range of mammalian species and glands, the predominant tissue type that composes EDs is pseudostratified epithelium. In some species, there is a progression of epithelial types: the proximal EDs are composed of simple cuboidal or columnar epithelium that, in the excurrent direction, usually gives way to the pseudostratified variety. Secretory granules are visible in the apical cytoplasm of the principal cells of the EDs of only a few species, but histochemistry has shown the presence of a variety of glycoproteins in these cells in a spectrum of species. Moreover, the latter methodology has revealed the presence of a variety of oxidative, acid hydrolytic, and transport enzymes in the EDs, showing that, rather than simply acting as a conduit for saliva, these ducts play a metabolically active role in gland function. It is difficult to describe a "typical" mammalian ED because it can vary along its length and interspecific variation does not follow a phylogenetic pattern. Moreover, in contrast to intercalated and striated ducts, ED cellular features do not exhibit a relationship to diet. Anat Rec Part A 288A: 498 -526, 2006.

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Immunohistochemical Expression of E-Cadherin in Salivary Glands and Their Tumors.

Cited by 7 publications

References 25 publications

Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study

Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study

Immunohistochemical detection of E-cadherin in certain types of salivary gland tumours

Interlobular excretory ducts of mammalian salivary glands: Structural and histochemical review

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