Immunohistochemical expression of cytokeratins in human salivary gland acinic cell carcinomas

Li, Xiaojie; Shi, Zhicai; Wang, Yuancai; Liu, Yang; Liu, Tingjiao

doi:10.1016/j.oooo.2015.04.014

Cited by 7 publications

(4 citation statements)

References 57 publications

(58 reference statements)

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“…Regarding the variable results of the immunohistochemistry panel and special staining techniques observed in the cases of AciCC included in this systematic review, it is possible to conclude that the diagnosis of AciCC is mainly morphological. The literature suggests that CK7 and CK19 may vary according to the histopathological pattern of AciCC, and CK14 and CK20 are negative in this tumor 23 . In this context, a recent study of Wong et al demonstrated that the nuclear receptor subfamily 4 group A member 3 (NR4A3) may be a highly sensitive and specific immunohistochemical marker for AciCC 24 .…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

Kirschnick

Silveira

Schuch

et al. 2021

J Oral Pathology Medicine

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Background The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid‐Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high‐grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high‐grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

Kirschnick

Silveira

Schuch

et al. 2021

J Oral Pathology Medicine

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“…Cytokeratin 7 was performed on seven cases in the current study, with positivity in all cases, including two papillary cystic lesions and three cases with mixed patterns. 18 Surgical excision alone was performed in 59.19% of the cases, with 22.45% receiving a combination of surgery and radiation therapy. Complete surgical excision is the mainstay of treatment for AciCC and it is associated with the best prognostic outcome.…”

Section: Discussionmentioning

confidence: 99%

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study

et al. 2023

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The aim of this study was to describe the prevalence, clinicopathological, and prognostic features of acinic cell carcinoma (AciCC) of the oral and maxillofacial region. AciCC cases were retrospectively retrieved from 11 pathology centers of three different countries. Medical records were examined to extract demographic, clinical, pathologic, and follow-up information. A total of 75 cases were included. Females (65.33%) with a mean age of 45.51 years were mostly affected. The lesions usually presented as an asymptomatic (64.28%) nodule (95.66%) in the parotid gland (70.68%). The association of two histopathological patterns was the most common finding (48.93%) and the tumors presented mainly conventional histopathological grades (86.11%). Surgical treatment was performed in the majority of the cases (59.19%). Local recurrence was observed in 20% of the informed cases, regional metastasis in 30.43%, and distant metastasis in 12.50%. The statistical analysis showed that the cases with a solid histopathological pattern (p=0.01), high-grade transformation (p=0.008), recurrence (p=0.007), and regional metastasis (p=0.03) were associated with poor survival. In conclusion, high histopathological transformation, presence of nodal metastasis, and recurrence were prognostic factors for AciCC of the oral and maxillofacial region.

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“…Most rainfall occurred during June and September (Chen et al, 2007;Fu et al, 2017). The Loess Plateau is covered by thick loess and is well-known as the largest region with loess deposition, which is suitable for agriculture (Li et al, 2015). Gullies developed well in this topographically fragmented plateau (Cai, 2001;Li et al, 2003).…”

Section: Description Of the Study Areamentioning

confidence: 99%

The vegetation–topography heterogeneity coupling in the Loess Plateau, China

Luo,

Liu,

Zhou

2024

Front. Environ. Sci.

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As a result of adaptation to the environment, the great environmental spatial heterogeneity leads to the high spatial heterogeneity of vegetation status. This coupling may be more apparent in water-limited drylands, where topography is the main determinant of small-scale variation in water availability and energy. Metrics describing this coupling may contribute to the detection of the extension of vegetation reshaped by human intervention and other driven forces. In this study, the heterogeneity index of coupling (HIC) was developed to indicate the coupling between spatial heterogeneity of vegetation status (Hv) and the spatial heterogeneity of topography (HT) in the Loess Plateau in northern China. The 16-day composed MODIS normalized vegetation index (NDVI) with a resolution of 250 m and SRTM DEM were employed to quantify the heterogeneity of vegetation status and the topographical heterogeneity. The results show that HIC varies among geomorphic zones, land cover types, and land cover change categories. Among all land cover types, HIC of sandy areas was the largest, followed by the HIC of the forest, shrub, farmland, and grassland. Among geomorphic zones, the highest HIC value appeared in plains with dense residential areas, followed by sandy land that is frequently reshaped by wind, rocky mountainous areas, hilly and gully loess plateaus, and loess tableland. It was revealed that the alternation of vegetation by human activities and natural disturbances shaped greater HIC. Results of this study approved the effectiveness of the HIC in reflecting the coupling of the vegetation status with topography at regional scale.

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Immunohistochemical expression of cytokeratins in human salivary gland acinic cell carcinomas

Cited by 7 publications

References 57 publications

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study

The vegetation–topography heterogeneity coupling in the Loess Plateau, China

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