Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

Abstract

Background The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid‐Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high‐grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high‐grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case.

Acinic cell carcinoma of the parotid gland: Timeo Danaos et dona ferentes? A multicenter retrospective analysis focusing on survival outcome

“…AciCC with high-grade transformation is considered to be more aggressive and predictive of recurrence and distant metastases; despite a histologic grading system is still lacking, frequent mitosis, ki-67 proliferation > 5%, perineural and vascular invasion, infiltration and tumour necrosis are regarded as high-grade features, explaining the aggressive behaviour of these dedifferentiated tumours [ 21 , 22 ]. The largest case series reported by Scherl et al [ 9 ] found a subgroup of patients with high-grade features showing poor outcomes, suggesting how histologic grade can be a stronger predictor of surgical than T and N classification.…”

“…Acinic cell carcinoma (AciCC) is the fourth most common epithelial tumour of salivary glands after mucoepidermoid carcinoma, adenocarcinoma (not otherwise specified, NOS) and adenoid cystic carcinoma [ 1 ]; it can be considered an extremely rare tumour (it comprises 9–11% of all adult parotid malignancies) [ 2 ] and its incidence has been previously described by the Surveillance of Rare Cancers in Europe Working Group (RARECARE) as 1.20–1.63 cases per 1,000,000 patients/years [ 3 ]. The definition of AciCC is constantly evolving over time; first observed in 1892 from Nasse [ 4 ] as a benign lesion and called “adenoma”, it was described by Buxton et al [ 5 ] as a malignant tumour with the ability to metastasize and recur.…”

Acinic cell carcinoma of the oral and maxillofacial region: an international multicenter study

“…Most cases presented as an indolent mass. 5 Histologically, AciCC shows four main patterns: solid, papillary cystic, microcystic, and follicular. These patterns may occur individually or in combination, without a prognostic significance.…”

“…These patterns may occur individually or in combination, without a prognostic significance. 5,6 Although AciCC Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

PON3::LCN1 and HTN3::MSANTD3 Gene Fusions With NR4A3/NR4A2 Expression in Salivary Acinic Cell Carcinoma

“…A cinic cell carcinoma (AciCC) is a low-grade carcinoma characterized by acinic cell differentiation, comprising ~10% of salivary gland carcinomas. [1][2][3][4] With the advent of genetic analysis, an increasing number of gene and chromosome aberrations have been identified, offering new potential avenues for investigating both differential diagnosis and prognosis of a spectrum of salivary gland carcinomas. 5 For instance, the CRTC1/3::MAML2 fusion 6 has been reported in mucoepidermoid carcinoma and tends to be associated with favorable survival rates.…”