Immunohistochemical expression of CK20, CK7, and CDX2 in colorectal carcinoma in correlation with pathomorphological characteristics

Ilieva, Nevena; Tashkova, Desislava; Staykov, Dmitrii G.; Serteva, Denitsa; Feodorova, Yana; Mehterov, Nikolay; Mollova, Angelina; Bachurska, Svitlana

doi:10.3897/folmed.64.e60950

Cited by 3 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cattle exposed to Pb have higher levels of lipid peroxidation in their kidneys ( 23 , 120 ). Long-term Pb exposure causes the kidney to produce lipid peroxidation and free radicals, which lead to a loss of membrane permeability and the inactivation of components of tubular cells ( 121 , 122 ). Pb affects the amount of Glutathione (GSH) and the function of antioxidant enzymes like catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione S-transferase (GST) in cattle ( 123 ).…”

Section: Heavy Metals: Their Toxicity Mechanism and Effectsmentioning

confidence: 99%

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

Tahir

Alkheraije

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Toxicity with heavy metals has proven to be a significant hazard with several health problems linked to it. Heavy metals bioaccumulate in living organisms, pollute the food chain, and possibly threaten the health of animals. Many industries, fertilizers, traffic, automobile, paint, groundwater, and animal feed are sources of contamination of heavy metals. Few metals, such as aluminum (Al), may be eliminated by the elimination processes, but other metals like lead (Pb), arsenic (As), and cadmium (Ca) accumulate in the body and food chain, leading to chronic toxicity in animals. Even if these metals have no biological purpose, their toxic effects are still present in some form that is damaging to the animal body and its appropriate functioning. Cadmium (Cd) and Pb have negative impacts on a number of physiological and biochemical processes when exposed to sub-lethal doses. The nephrotoxic effects of Pb, As, and Cd are well known, and high amounts of naturally occurring environmental metals as well as occupational populations with high exposures have an adverse relationship between kidney damage and toxic metal exposure. Metal toxicity is determined by the absorbed dosage, the route of exposure, and the duration of exposure, whether acute or chronic. This can lead to numerous disorders and can also result in excessive damage due to oxidative stress generated by free radical production. Heavy metals concentration can be decreased through various procedures including bioremediation, pyrolysis, phytoremediation, rhizofiltration, biochar, and thermal process. This review discusses few heavy metals, their toxicity mechanisms, and their health impacts on cattle with special emphasis on the kidneys.

show abstract

Section: Heavy Metals: Their Toxicity Mechanism and Effectsmentioning

confidence: 99%

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

Tahir

Alkheraije

2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…K20 als sog. intestinales Keratin kommt charakteristischerweise in kolorektalen Adenokarzinomen vor [ 15 ]. Bei soliden Karzinomen sind K5/K6 und K8/K18 zur Erkennung des plattenepithelialen bzw.…”

Section: Tumorgruppen Und Immunhistochemische Markerunclassified

CUP-Syndrom – Diagnostik aus Sicht der Pathologie

Pauli

2023

Radiologie

View full text Add to dashboard Cite

Zusammenfassung Problemstellung Die histologische und immunhistochemische Aufarbeitung von Tumormaterial aus Metastasen eines bis dahin unbekannten Primärtumors („cancer of unknow primary“, CUP) ist ein wichtiges Werkzeug zur Identifizierung ihrer Herkunft, reicht aber hierfür ohne klinisch-onkologische und radiologische Beurteilung oft nicht aus. Vorgehen Bei der initialen CUP-Situation tragen die histologische und immunhistochemische Aufarbeitung sowie die klinisch-radiologische Korrelation wesentlich zur Identifikation des Primärtumors bei. Mittlerweile gibt es akzeptierte Richtlinien, denen man während der CUP-Diagnostik folgen kann. Mittels molekularer Diagnostik werden Veränderungen auf der Ebene von Nukleinsäuren untersucht, was u. a. auch Hinweise für den Primärtumor geben kann. Gelingt es trotz breiter und interdisziplinärer Diagnostik nicht, den Primärtumor zu identifizieren, handelt es sich um ein CUP-Syndrom. Liegt eine echte CUP-Situation vor, gilt es, den Tumor so gut wie möglich einer Tumorklasse oder einer bestimmten therapiesensitiven Untergruppe zuzuordnen, so dass die bestmögliche Therapie erfolgen kann. Für eine endgültige Zuordnung zu einem Primärtumor oder eine Einstufung als CUP ist jedoch ein Abgleich mit medizinisch-onkologischen und bildgebenden Befunden unentbehrlich. Schlussfolgerung Beim Verdacht auf ein CUP-Syndrom ist eine enge interdisziplinäre Abstimmung zwischen Pathologie, medizinischer Onkologie und Bildgebung unerlässlich, um eine tragfähige Einstufung als CUP oder eine Identifizierung eines anzunehmenden Primärtumors zu erreichen, im Interesse einer möglichst spezifischen und wirksamen Therapie für die betroffenen Personen.

show abstract

Single metachronous bone metastasis following rectal adenocarcinoma: A case report

Matías‑García,

Mendoza‑Moreno,

Díez‑Alonso

et al. 2024

Med Int

View full text Add to dashboard Cite

Colorectal cancer (CrC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of metastases either at the time of diagnosis or during follow-ups. Unlike certain other types of cancer, such as breast, prostate, or lung cancer, where bone tissue is a common site for secondary dissemination, CrC primarily spreads to the lymph nodes, liver and lungs. the occurrence of bone metastases from CrC is rare and usually coincides with tumor involvement in other locations. risk factors for bone metastases include the location of the primary tumor, the age of the patients, KraS mutations and the degree of tumor differentiation. Unlike metastases to the liver and lungs, bone metastases tend to be symptomatic, affecting the patient's quality of life and resulting in a poorer prognosis with shorter survival rates. the approach to patient management needs to be personalized. the present study describes the of a patient who underwent surgery for stage IV rectal adenocarcinoma and later developed a metastasis in the costal wall 79 months post-intervention, with no evidence of recurrence at other sites.

show abstract

Immunohistochemical expression of CK20, CK7, and CDX2 in colorectal carcinoma in correlation with pathomorphological characteristics

Cited by 3 publications

References 9 publications

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

CUP-Syndrom – Diagnostik aus Sicht der Pathologie

Single metachronous bone metastasis following rectal adenocarcinoma: A case report

Contact Info

Product

Resources

About