Immunohistochemical Detection of Galectin-3 in Canine Gastric Carcinomas

Woo, Hee-Jong; Joo, Hong‐Gu; Shi, Song; Sohn, Young-Hae; Chae, Chanhee

doi:10.1053/jcpa.2000.0442

Cited by 16 publications

(10 citation statements)

References 8 publications

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“…Choi et al (15) and de Oliveira (16) clearly demonstrated that galectin-3 was overexpressed in adenoma but not in adenocarcinoma and that low expression of galectin-3 was associated with canine mammary tumor progression. In contrast, high expressions of galectin-3 in invasive neoplastic cells in canine gastric carcinoma suggested an important role in metastasis (24). In this study, CTVTs were intracytoplasmically stained with galectin-3 in both groups.…”

Section: Lectinsmentioning

confidence: 54%

The effects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specific for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

ÖZYİĞİT¹,

NAK²,

AKŞİT³

et al. 2014

Turk J Vet Anim Sci

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Section: Lectinsmentioning

confidence: 54%

The effects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specific for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

ÖZYİĞİT¹,

NAK²,

AKŞİT³

et al. 2014

Turk J Vet Anim Sci

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“…Interestingly, galectin-3 suppresses apoptosis in vitro through a cell death inhibition pathway that involves Bcl-2 (Yang et al 1996). The expression of galectin-3 has also been identified in various types of tumor cells both in vivo (Oda et al 1991;Woo et al 2001;Takenaka et al 2003) and in vitro (Cebo et al 2002), suggesting a possibility that it stimulates tumor cell proliferation by inhibiting cell death. It is well known that the major population of aged epithelial cells in the gut move to luminal sides and drop off into the lumen for epithelial renewal; therefore, galectin-3 may act to prevent epithelial cells from cell death at the terminal sites of maturation.…”

Section: Discussionmentioning

confidence: 99%

Differential Cellular Expression of Galectin Family mRNAs in the Epithelial Cells of the Mouse Digestive Tract

Nio

Kon

Iwanaga

2005

J Histochem Cytochem.

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Galectin is an animal lectin that recognizes beta-galactosides of glycoconjugates and is abundant in the gut. This study revealed the cellular expression of galectin subtypes throughout the mouse digestive tract by in situ hybridization. Signals for five subtypes (galectin-2, -3, -4/6, and -7) were detected exclusively in the epithelia. In the glandular stomach, galectin-2 and -4/6 were predominantly expressed from gastric pits to neck of gastric glands, where mucous cells were the main cellular sources. The small intestine exhibited intense, maturation-associated expressions of galectin-2, -3, and -4/6 mRNAs. Galectin-2 was intensely expressed from crypts to the base of villi, whereas transcripts of galectin-3 gathered at villous tips. Signals for galectin-4/6 were most intense at the lower half of villi. Galectin-2 was also expressed in goblet cells of the small intestine but not in those of the large intestine. In the large intestine, galectin-4/6 predominated, and the upper half of crypts simultaneously contained transcripts of galectin-3. Stratified epithelium from the lip to forestomach and anus intensely expressed galectin-7 with weak expressions of galectin-3. Because galectins in the digestive tract may be multi-functional, information on their cell/stage-specific expression contributes to a better understanding of the functions and pathological involvements of galectins.

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“…Galectin-3 plays a role in a variety of physiological and pathological processes. Studies of pancreatic [ 112 ], gastric carcinomas [ 113 ] found galectin-3 to be upregulated in these tissues compared to normal tissues. Studies conducted by Schoeppner et al [ 114 ] also revealed that galectin-3 expression is related to neoplastic transformation and progression towards metastasis in colon carcinoma.…”

Section: Galectins In Cervical Cancermentioning

confidence: 99%

The Role of Galectins in Cervical Cancer Biology and Progression

Wang

Zhao

Wang

et al. 2018

BioMed Research International

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Cervical cancer is one of the malignant tumors with high incidence and high mortality among women in developing countries. The main factors affecting the prognosis of cervical cancer are the late recurrence and metastasis and the effective adjuvant treatment, which is radiation and chemotherapy or combination therapy. Galectins, a family containing many carbohydrate binding proteins, are closely involved in the occurrence and development of tumor. They are involved in tumor cells transformation, angiogenesis, metastasis, immune escape, and sensitivity against radiation and chemotherapy. Therefore, galectins are deemed as the targets of multifunctional cancer treatment. In this review, we mainly focus on the role of galectins, especially galectin-1, galectin-3, galectin-7, and galectin-9 in cervical cancer, and provide theoretical basis for potential targeted treatment of cervical cancer.

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Immunohistochemical Detection of Galectin-3 in Canine Gastric Carcinomas

Cited by 16 publications

References 8 publications

The effects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specific for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

The effects of vincristine sulfate on expression of galectin-3, Bcl-2, and carbohydrate structures specific for EEL, GSL-1, and RCA-1 lectins in bitches with naturally occurring canine transmissible venereal tumor

Differential Cellular Expression of Galectin Family mRNAs in the Epithelial Cells of the Mouse Digestive Tract

The Role of Galectins in Cervical Cancer Biology and Progression

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