Immunohistochemical analysis of vascular endothelial growth factor (VEGF) and p53 expression in pterygium from Tunisian patients

The expression of vascular endothelial growth factor in mast cells promotes the neovascularisation of human pterygia

“…Previous studies have shown that VEGF and neovessels play an important role in the pathogenesis of pterygia 17 18. Moreover, the important role of mast cells in the development of pterygia has also been reported 12 19.…”

The expression and significance of p53 protein and Ki-67 protein in pterygium

“…In studies the presence of elevated level of stabilized p53 protein which can be detected by immunohistochemistry in the epithelium of pterygium has been found 2,[10][11][12][13][14][15][16] . Previous studies found that the prevalence of p53 positive pterygium were inside of a wide range of 7.9% to 100% [10][11][12][13][14][15][16] . Using the antibody DO1 Dushku et al 6 found, immunopositivity for p53 protein in 100% of analyzed pterygia.…”

“…Protein p53 is the guardian of the physical integrity of the cellular genome and inactivation of p53 function eliminates a major barrier for tumorigenesis and increased proliferation. The prevalence of p53 positive samples of pterygium is within a wide range of 7.9% to 100% [10][11][12][13][14][15][16] . The cause of the different prevalence of p53 protein expression remains unknown.…”

Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca2+Influx Dysfunction in Human Pterygial Cells

“…6 Vascular endothelial growth factor (VEGF) and its cognate receptor are upregulated in pterygium tissue (PT). [8][9][10] Retention of the pterygial cell phenotype appears to be location specific, as this tissue does not infiltrate into the cornea, suggesting that the corneal milieu is not supportive of this process. 2 Transient receptor potential (TRP) channels constitute a superfamily of ligand-gated, nonselective cation channels subdivided into seven subfamilies according to differences in amino acid sequence homology (reviewed by Ramsey et al 11 ).…”