Immunohistochemical analysis of the early ontogeny of the neuropeptide Y system in rat brain

Woodhams, P.L.; Allen, Y.S.; McGovern, J.; Allen, Janet M.; Bloom, Stephen R.; Balázs, R.; Polak, Julia M.

doi:10.1016/0306-4522(85)90131-9

Cited by 142 publications

(64 citation statements)

References 43 publications

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“…Development of NPY-ir neurons in the human associative PFC has not been studied before. However, data on the cortical development of NPY immunoreactivity exist for rodents (Foster and Schultzberg, 1984;Woodhams et al, 1985;Cavanagh and Parnavelas, 1990) and cats (Wahle and Meyer, 1987;Chun and Shatz, 1989a;Hogan and Berman, 1992). These data indicate an early presence, a protracted increase in density of NPY-ir neurons, and a transient expression of these neurons in the lower cortical layers and subplate, with the cat visual cortex being the exception in one study (Hogan and Berman, 1992).…”

Section: Indexing Terms: Subplate Zone; Cortical Plate; Marginal Zonementioning

confidence: 84%

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

et al. 1997

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Neuropeptide Y (NPY) is present in neurons of the adult human cerebral cortex. In view of the reported roles of NPY in the central nervous system in health and during certain disease conditions, we have studied normal development of NPY immunoreactivity (-ir) in the human prefrontal cortex (PFC), Brodmann areas 9 and 46. Twenty-six specimens ranging from the ages of 14 postovulatory weeks to 34 years exhibited patterns that revealed six periods in the development of the laminar distribution and density of NPY-ir neurons. Changes during prenatal and perinatal periods reflect the onset, development, and resolution of the transient fetal telencephalic compartments, including the subplate zone, in which NPY-ir neurons are especially abundant. Before the age of 1 year, the majority of NPY-ir neurons were found in the subplate zone, whereas, after 1 year, the majority were seen in the cortical layers. This is in contrast with the human visual cortex, where the majority of NPY-ir neurons were still located in the white matter. The density of cortical NPY-ir neurons increased in the fifth developmental period (ages 4-7 years), coinciding with the increase of cortical volume and marked progression of cognitive functions. The adult pattern of a relatively low density of cortical NPY-ir neurons was reached in period 6 (from about 8 years), when individual variation also became apparent. Our data point to a protracted maturation of NPY-ir in the human PFC and to different distribution patterns of NPY-ir neurons in different cortical areas.

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Section: Indexing Terms: Subplate Zone; Cortical Plate; Marginal Zonementioning

confidence: 84%

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

et al. 1997

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“…A narrow peak of doublelabeling occurs at E15-16 and is coincident with the period when somatostatin is first biochemically detectable in the striatum (Kessler, 1986). Somatostatin-or neuropeptide Y-immunoreactive striatum neurons are immunohistochemically detectable by E18 (Shiosaka et al, 1982;Woodhams et al, 1985), first in ventrolateral parts of the caudate-putamen and then extending to more dorsal areas. Unlike PV-positive and cholinergic interneurons, somatostatin-containing neurons do not show a clear dorsoventral, rostrocaudal, or mediolateral gradient of neurogenesis .…”

Section: Neurogenesis Of Pv Interneurons Of the Neostriatummentioning

confidence: 93%

Neurogenesis in the mammalian neostriatum and nucleus accumbens: Parvalbumin-immunoreactive GABAergic interneurons

Sadikot

Sasseville

1997

J. Comp. Neurol.

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We study the neurogenesis of a distinct subclass of rat striatum gamma-aminobutyric acid (GABA)ergic interneurons marked by the calcium-binding protein parvalbumin (PV). Timed pregnant rats are given an intraperitoneal injection of bromodeoxyuridine (BrdU), a marker of cell proliferation, on designated days between embryonic day (E) 11 and E22. Birthdate of PV neurons is determined in the adult neostriatum and nucleus accumbens by using a BrdU-PV double-labeling immunohistochemical technique. PV-immunoreactive interneurons of the neostriatum show maximum birthrates (>10% double-labeling) between E14-E17, whereas PV-immunoreactive interneurons of the nucleus accumbens show maximum double-labeling between E16-E19. In the neostriatum, caudal PV-immunoreactive neurons are born before those at rostral levels, and lateral PV-immunoreactive neurons become postmitotic before medial neurons. In the postcommissural striatum, ventral PV-immunoreactive neurons become postmitotic before dorsal neurons. In the precommissural striatum, ventral neurons are born before dorsal neurons laterally, but a dorsoventral gradient is seen medially. At corresponding coronal levels, PV-immunoreactive neurons of the nucleus accumbens are born shortly after PV neurons of the neostriatum. Analysis of BrdU labeling intensity in the nucleus accumbens shows that medium spiny projection neurons of the shell become postmitotic before neurons of the core. Similarly, PV-immunoreactive interneurons of the nucleus accumbens shell are born before PV interneurons of the core. Compared with cholinergic interneurons of the neostriatum, PV-immunoreactive interneurons are born later, but neurogenetic gradients are similar. The period of striatum PV interneuron genesis encompasses the period for somatostatin interneurons, although the latter neurons do not show neurogenetic gradients, possibly due to heterogeneous subtypes. Consideration of basal telencephalon neurogenesis suggests that subpopulations of striatum interneurons may share common neurogenetic features with phenotypically similar populations in the basal forebrain, with final morphology and connectivity depending on local cues provided by the host environment.

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“…Several lines of evidence indicate that the immediate post-natal period is of particular importance for the long-term programming of nervous functions in the rodent. Notably, the development of the hypothalamic appetite regulatory network in rats and mice occurs predominantly after birth [44][45][46][47] . It therefore remains to be determined to what extent the altered regulatory action of 5-hT on the ontogenesis of reflexes and on body weight control is dependent on the type and subtype of serotonergic receptors, as well as on the developmental period during which serotonin modulation takes place.…”

Section: Discussionmentioning

confidence: 99%

Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

Deiró

Carvalho

Nascimento

et al. 2008

Arq. Neuro-Psiquiatr.

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-Serotonin influences the growth and development of the nervous system, as well as its behavioral manifestations. The possibility exists that increased brain serotonin availability in young animals modulates their neuro-behavioral responses. This study investigated the body weight gain and reflex ontogeny of neonatal rats treated during the suckling period with two doses of citalopram (5 mg, or 10 mg/kg, sc, daily). The time of the appearance of reflexes (palm grasp righting, free-fall righting, vibrissa placing, auditory startle response, negative geotaxis and cliff avoidance) as well as the body weight evolution were recorded. In general, a delay in the time of reflex development and a reduced weight gain were observed in drug-treated animals. These findings suggest that serotoninergic mechanisms play a role in modulating body weight gain and the maturation of most reflex responses during the perinatal period in rats.Key wordS: serotonin, programming, SSrI, citalopram, reflex development. Exposição neonatal ao citalopram, um inibidor seletivo da recaptação de serotonina, programa retardo na ontogênese reflexa em ratosResumo -A serotonina influencia o crescimento e o desenvolvimento do sistema nervoso e sua expressão comportamental. o aumento da disponibilidade de serotonina no cérebro de ratos jovens parece modular as respostas neurocomportamentais. Neste estudo, foram investigados o ganho de peso corporal e a ontogênese dos reflexos em ratos neonatos, tratados diariamente, durante o período de aleitamento, com duas doses de citalopram (5 ou 10 mg/Kg de peso corporal, via subcutânea). Foram avaliados, o tempo de aparecimento dos reflexos (preensão palmar, endireitamento, colocação pelas vibrissas, resposta ao susto, geotáxico negativo e aversão ao precipício), e a evolução do peso corporal. Foi observado atraso no tempo de desenvolvimento de alguns reflexos e redução no ganho de peso corporal. os achados em ratos sugerem que as alterações no ganho de peso corporal e na maturação dos reflexos são programadas, durante o período perinatal, com participação de mecanismos serotoninérgicos de modulação.

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Immunohistochemical analysis of the early ontogeny of the neuropeptide Y system in rat brain

Cited by 142 publications

References 43 publications

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

Neurogenesis in the mammalian neostriatum and nucleus accumbens: Parvalbumin-immunoreactive GABAergic interneurons

Neonatal exposure to citalopram, a serotonin selective reuptake inhibitor, programs a delay in the reflex ontogeny in rats

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