Immunohistochemical analysis of MMP-13 and EMMPRIN in epithelial odontogenic lesions

Santos, Pedro Paulo de Andrade; Nonaka, Cassiano Francisco Weege; Barboza, Carlos Augusto Galvão; Pinto, Leão Pereira; Souza, Lélia Batista de

doi:10.1007/s00405-019-05589-0

Cited by 5 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the intensity of (mild, moderate, and strong). While fibroblast expression of the cyst wall was scored into: 0 (≤ 10% immunostained cells), 1 (11-25% immunostained cells), 2 (26-50% immunostained cells), 3 (51-75% immunostained cells), and 4 (> 75% immunostained cells) 17 .…”

Section: Immunohistochemical Staining and Evaluationmentioning

confidence: 99%

Impact of Immunohistochemical Expression of Collagen III and MMP-14 in Odontogenic Keratocyst

Hassan,

Garib,

Mohammad

2023

SDJ

View full text Add to dashboard Cite

Objective: Immunohistochemical expression of collagen III and MMP14 was evaluated in odontogenic keratocyst, and correlated tothe clinicopathological parameters to remark on the role of these markers in the biological behavior of the cyst.Methods: Twenty-three odontogenic keratocysts samples were collected from three pathological laboratories in Sulaimani.Demographic information and the available radiographic investigation were recorded. The immune expression of collagen III andMMP14 was evaluated and related to the clinicopathological variables. Chi-square test was used for analysis and a p-value of 0.05 wascut off point for significance.Results: Males were predominantly affected by odontogenic keratocysts lesions (69.6%), which were mainly detected in the >35 yearsage groups. Keratocyst lesions were seen more frequently in the mandible (82.6%), with well-defined borders, and unilocularappearance. Collagen III was oriented more commonly in a parallel direction (70.8%), with moderate intensity (45.8%). MMP14revealed cytoplasmic expression in the epithelial lining of the keratocyst (100%), score 3 was the most prevalent expression (54.2%)in the cystic wall, and prominent inflammation and epithelial separation were detected with high scoring of MMP14, which were(57.1%) and (56.3%) respectively.Conclusions: Both markers had independent combined roles in the cyst’s biological behavior, including the prevalent parallel direction of the collagen III, while overexpression of the MMP14 might have an impact role in the aggressive behavior of the lesion.

show abstract

Section: Immunohistochemical Staining and Evaluationmentioning

confidence: 99%

Impact of Immunohistochemical Expression of Collagen III and MMP-14 in Odontogenic Keratocyst

Hassan,

Garib,

Mohammad

2023

SDJ

View full text Add to dashboard Cite

show abstract

“…MMPs are found in a variety of human primary high expression in both sexual and metastatic tumors is directly related to poor tumor differentiation, invasion, and metastasis to secondary organs, including MMP‐1, MMP‐2, MMP‐3, MMP‐7, and others. MMPs can also help tumor cells to the migration and invasion by destroying and decomposing basement membranes and other physical barriers that hinder tumor cell migration and metastasis, such as GC, papillary thyroid carcinoma, and human testicular germ cell tumors (N. Cui et al, 2017; de Andrade Santos et al, 2019; Milia‐Argeiti et al, 2012; Mrena et al, 2006; J. R. Wang et al, 2013). Apelin/APJ system can regulate the expression and release of MMPs in E14.5 mouse embryos skin cells, such as MMP‐2 and MMP‐9 (Kidoya et al, 2015).…”

Section: Role Of Apelin/apj System In Cancer Development and Progressionmentioning

confidence: 99%

Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target

Chen

Zhao

et al. 2022

Journal Cellular Physiology

View full text Add to dashboard Cite

Cancer is a disease that seriously endangers human health and is mainly characterized by a high metastasis rate, a high recurrence rate, and a high mortality rate. The treatment of cancer has always been an important research direction of scientific research. A number of studies have shown that the apelin/APJ system is involved in the development and poor prognosis of a variety of cancers, such as lung cancer, liver cancer, cholangiocarcinoma, breast cancer, glioblastoma, prostate cancer, ovarian cancer, and so on. Accumulating evidence has also shown that the apelin/APJ system acts as a biomarker and predictor of postoperative effects in multiple cancers, which can also affect the tumor microenvironment and the efficacy of cancer immunotherapy. Considering that the apelin/APJ system may be a potential target for cancer treatment, it is of great significance for the study of new cancer treatment targets. To better understand the role of the apelin/APJ system on the occurrence and development of cancer, this article reviews the role of the apelin/APJ system in the occurrence and development of various cancers, angiogenesis, tumor stem cells, tumor microenvironment, drug resistance, poor prognosis, and the research progress of related anticancer drugs.

show abstract

“…Odontogenic lesions are a heterogeneous group of diseases that affect the jaws and include cysts and neoplasms originating from the epithelial or mesenchymal remnants of dental embryogenesis. These lesions are characterized by a broad biological behavior ranging from changes in tissue development (hamartomas), cysts, nonaggressive and aggressive benign tumors to malignant tumors 1…”

mentioning

confidence: 99%

“…These lesions are characterized by a broad biological behavior ranging from changes in tissue development (hamartomas), cysts, nonaggressive and aggressive benign tumors to malignant tumors. 1 Among jaw lesions, the prevalence of odontogenic cysts and tumors is considerable. Radicular cysts are the most common cysts, followed by dentigerous cysts and odontogenic keratocysts.…”

mentioning

confidence: 99%

BMP-2 and Noggin Immunoexpression in Ameloblastomas, Odontogenic Keratocysts, and Dentigerous Cysts

Santos¹,

Nascimento

Queiroz

et al. 2022

Applied Immunohistochemistry &Amp; Molecular Morphology

View full text Add to dashboard Cite

BMP-2 and Noggin are expressed in several tissues and participate in cell differentiation and proliferation during odontogenesis and tumor development. We evaluated the immunohistochemical expression of these proteins in ameloblastomas (AMs), odontogenic keratocysts (OKCs), and dentigerous cysts (DCs). The expression in AM (n.20), OKC (n.20), and DC (n.20) was evaluated by the percentage of positive cells and expression intensity, resulting in a total immunostaining score. Analysis of BMP-2 and Noggin revealed positivity in all cases. The Mann-Whitney test showed a statistically significant difference for Noggin between AM and DC and between OKC/DC. The mean DC scores were always higher than those of the other groups, regardless of the assessment method. Individual analysis of each lesion showed a positive and significant correlation between the percentage of cells positive for BMP-2 and Noggin in DC. We demonstrated the presence of BMP-2 and Noggin in AMs/OKCs/DCs. Marked expression of BMP-2 was observed in OKCs and AMs. There was also a positive correlation between BMP-2 and Noggin in DCs, suggesting a greater role of these markers in the bone formation and remodeling process since DCs are characterized by phases of bone quiescence and healing.

show abstract

Immunohistochemical analysis of MMP-13 and EMMPRIN in epithelial odontogenic lesions

Cited by 5 publications

References 35 publications

Impact of Immunohistochemical Expression of Collagen III and MMP-14 in Odontogenic Keratocyst

Impact of Immunohistochemical Expression of Collagen III and MMP-14 in Odontogenic Keratocyst

Roles of apelin/APJ system in cancer: Biomarker, predictor, and emerging therapeutic target

BMP-2 and Noggin Immunoexpression in Ameloblastomas, Odontogenic Keratocysts, and Dentigerous Cysts

Contact Info

Product

Resources

About